Skip to main content
SpringerLink
Log in

Inducers and Inhibitors of Leukemic Cell Differentiation in Culture

  • Chapter
Tissue Growth Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 57))

Abstract

Bone marrow cells differentiate into well-defined lineages, producing erythroid, myeloid, monocytic, megakaryocytic, and lymphoid cells (see reviews by Metcalf and Moore, 1971; Quesenberry and Levitt, 1979 a, b, c). The stem cells in the bone marrow have the potential of giving rise to cells of different lineages. The stem cells have been only partially identified in man, but a cell clearly capable of reconstituting bone marrow has been identified in the mouse (Metcalf, 1977). The stem cell committment to differentiation is best described by a stochastic model (Till et al, 1964). A stem cell, at random, either becomes committed to a particular lineage and gives rise to morphologically recognizable progenitor cells of that lineage, or it remains uncommitted and retains the ability to generate other stem cells. Asymmetric cell division, in which a stem cell gives rise both to differentiated progenitor and undifferentiated cells is not thought to contribute significantly to maintaining the stem cell pool. The progenitor cells then divide further to form the terminally differentiated cells characteristic of each lineage. The end cells are incapable of further proliferation. They express differentiated functions and are capable of exerting feedback regulations on the bone marrow precursor cells (Moore, 1977; Moore et al., 1978).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abrahm, J., Rovera, G.: The effect of tumor promoting phorbol diesters on terminal differentiation of cells in culture. Mol. Cell. Biochem. 31, 165–175 (1980).

    PubMed  CAS  Google Scholar 

  • Adesnik, M., Snitkin, H.: Induction of erythroid differentiation in Friend leukemia cells by bromodeoxyuridine. J. Cell. Physiol. 95, 307–311 (1978).

    PubMed  CAS  Google Scholar 

  • Andersson, L.C, Jokinen, M., Gahmberg, CG.: Induction of erythroid differentiation in the human leukemia cell line K 562. Nature 278, 364–365 (1979a).

    PubMed  CAS  Google Scholar 

  • Andersson, L.C., Nilsson, K., Gahmberg, CG.: K 562 a human erythroleukemic cell line. Int. J. Cancer 23, 143–147 (1979 b).

    PubMed  CAS  Google Scholar 

  • Bernstein, A., Hunt, D.M., Crichley, V., Mak, T.W.: Induction by ouabain of hemoglobin synthesis in cultured Friend erythroleukemia cells. Cell 9, 375–381 (1976).

    PubMed  CAS  Google Scholar 

  • Bick, M.D., Cullen, B.R.: Bromodeoxyuridine inhibition of Friend leukemia cell induction by butyric acid: time course of inhibition, reversal and effect of other base analogs. Somatic Cell Gen. 2, 545–558 (1978).

    Google Scholar 

  • Boyer, S.H., Woo, K.D., Noyes, A.N., Young, R., Scher, W., Friend, C, Preisler, H.D., Bank, A.: Hemoglobin biosynthesis in murine virus induced leukemic cells in vitro: structure and amounts of globin chains produced. Blood 40, 823–835 (1972).

    PubMed  CAS  Google Scholar 

  • Breitman, T.R., Selonick, S.E., Collins, S.I.: Induction of differentiation of the human promyelocytic cell line (HL 60) by retinoic acid. Proc. Natl. Acad. Sci. U.S.A. 77, 2936–2940 (1980).

    PubMed  CAS  Google Scholar 

  • Christman, J.K., Price, P., Pedrinan, L., Acs, G.: Correlation between hypomethylation of dNA and expression of globin genes in Friend erythroleukemia cells. Eur. J. Biochem. 81, 53–61 (1977).

    PubMed  CAS  Google Scholar 

  • Cline, M.J., Golde, D.W.: Controlling the production of blood cells. Blood 53, 157–165 (1979).

    PubMed  CAS  Google Scholar 

  • Collins, S.J., Gallo, R.C., Gallagher, R.E.: Continuous growth and differentiation of human myeloid leukemic cells in suspension culture. Nature 270, 347–349 (1977).

    PubMed  CAS  Google Scholar 

  • Collins, S.J., Ruscetti, F.W., Gallagher, R.E., Gallo, R.C.: Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc. Natl. Acad. Sci. U.S.A. 75, 2458–2462 (1978).

    PubMed  CAS  Google Scholar 

  • Dabney, B.J., Beaudet, A.L.: Increase in globin chains and globin mRNA in erythroleukemia cells in response to hemin. Arch. Biochem. Biophys. 179, 106–112 (1977).

    PubMed  CAS  Google Scholar 

  • Dube, S.K., Gaedick, G., Kluge, N., Weismann, B.J., Melderis, H., Steinheider, G., Crozier, T., Beckmann, H., Ostertag, W.: Hemoglobin synthesizing mouse and human erythroleukemic cell lines as model systems for the study of differentiation and control of gene expression. Proc. 4th Int. Symp. of the Princess Takamatsu Cancer Research Fund, Tokyo, University Park Press, 99–132 (1974).

    Google Scholar 

  • Ebert, P.S., Malinin, G.I.: Induction of erythroid differentiation in Friend murine erythroleukemic cells by inorganic selenium compounds. Biochem. Biophys. Res. Commun. 86, 340–349 (1979).

    PubMed  CAS  Google Scholar 

  • Ebert, P.S., Wars, I., Buell, D.N.: Erythroid differentiation in cultured Friend leukemia cells treated with metabolic inhibitors. Cancer Res. 36, 1809–1813 (1976).

    PubMed  CAS  Google Scholar 

  • Eisen, H., Bach, R., Emery, R.: Induction of spectrin in erythroleukemia cells transformed by Friend virus. Proc. Natl. Acad. Sci. U.S.A. 74, 3898–3902 (1977).

    PubMed  CAS  Google Scholar 

  • Fialkow, P.J., Denman, A.M., Jacobson, R.J., Lowenthal, M.N.: Chronic myeloid leukemia. Origin of some lymphocytes from leukemic stem cells. J. Clin. Invest. 62, 815–823 (1978).

    PubMed  CAS  Google Scholar 

  • Fibach, E., Landau, T., Sachs, L.: Normal differentiation of myeloid leukemic cells induced by a differentiation inducing protein. Nature New Biol. 23, 276–278 (1972).

    Google Scholar 

  • Fibach, E., Reuben, R.C., Rifkind, R.A., Marks, P.A.: Effect of hexamethylene bisaceta-mide on the commitment to differentiation of murine erythroleukemia cells. Cancer Res. 37, 440–444 (1977).

    PubMed  CAS  Google Scholar 

  • Fibach, E., Gambari, R., Shaw, P.A., Maniatis, G., Reuben, R.C., Sassa, S., Rifkind, R.A., Marks, P.A.: Tumor promoter-mediated inhibition of cell differentiation: suppression of expression of erythroid functions in murine erythroleukemia cells. Proc. Natl. Acad. Sci. U.S.A. 76, 1906–1910 (1979).

    PubMed  CAS  Google Scholar 

  • Friend, C: Differentiation and neoplasia. Berlin, Heidelberg, New York: Springer 1980 (in press).

    Google Scholar 

  • Friend, C., Scher, W., Holland, J.G., Sato, T.: Hemoglobin synthesis in murine virus induced leukemia cells in vitro: stimulation of erythroid differentiation by DMSO. Proc. Natl. Acad. Sci. U.S.A. 68, 378–382 (1971).

    PubMed  CAS  Google Scholar 

  • Gallagher, R., Collins, S., Trujillo, J., McCredie, K., Ahearn, M., Tsai, S., Metzgar, R., Au-lakh, G., Ting, R., Ruscetti, F., Gallo, R.: Characterization of the continuous differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia. Blood 54, 713–733 (1979).

    PubMed  CAS  Google Scholar 

  • Gambari, R., Terada, M., Bank, A., Rifkind, R.A., Marks, P.A.: Synthesis of globin mRNA in relation to the cell cycle during induced murine erythroleukemia differentiation. Proc. Natl. Acad. Sci. U.S.A. 75, 3801–3804 (1978).

    PubMed  CAS  Google Scholar 

  • Gazitt, Y., Friend, C: Polyamine biosynthesis enzymes in the induction and inhibition of FL cell differentiation. Cancer Res. (1980).

    Google Scholar 

  • Geller, R., Levenson, R., Housman, D.: Significance of the cell cycle in commitment of murine erythroleukemia cells to erythroid differentiation. J. Cell. Physiol. 95, 213–222 (1978).

    PubMed  CAS  Google Scholar 

  • Gilbert, H.S., Mendelsohn, N., Acs, G., Christman, J.K.: Evidence for the myelomonocytic character of uninduced HL-60 cells. Blood 54 (Suppl. 1), 170a (1979).

    Google Scholar 

  • Greenberger, J.S.: Phorbol myristate acetate inhibits normal hemopoiesis but stimulates leu-kemogenesis in long term bone marrow cultures. Blood 54 (Suppl. 1), 171 a (1979).

    Google Scholar 

  • Gusella, J.F., Housman, D.: Induction of erythroid differentiation in vitro by purines and purine analogues. Cell 8, 263–269 (1976).

    PubMed  CAS  Google Scholar 

  • Gusella, G., Geller, R., Clarke, B., Weeks, V., Housman, D.: Commitment to erythroid differentiation by Friend erythroid leukemia cells: a stochastic analysis. Cell 9, 221–229 (1976).

    PubMed  CAS  Google Scholar 

  • Harrison, P.R.: The biology of the Friend cell. in: International review of biochemistry. Biochemistry of cell differentiation. Paul, J. (ed.), vol. 15, pp. 227–267. Baltimore: University Park Press 1977.

    Google Scholar 

  • Harrison, P.R.: New human myeloid leukaemia cell line undergoes red shift. Nature 281, 632–633 (1979).

    PubMed  CAS  Google Scholar 

  • Harrison, P.R., Rutherford, T., Conkie, D., Affara, N., Sommerville, J., Hissey, P., Paul, J.: Analysis of erythroid differentiation in Friend cells using non-induced variants. Cell 14, 61–70 (1978).

    PubMed  CAS  Google Scholar 

  • Honma, Y., Kasukabe, T., Okabe, J., Hozumi, M.: Glucocorticoid binding and mechanisms of resistance in some clones of mouse myeloid leukemic cells resistant to induction of differentiation by dexamethasone. J. Cell. Physiol. 93, 227–235 (1977a).

    PubMed  CAS  Google Scholar 

  • Honma, Y., Kasukabe, T., Okabe, J., Hozumi, M.: Glucocorticoid-induced differentiation of cultured mouse myeloid leukemia cells. Gann 68, 241–246 (1977b).

    PubMed  CAS  Google Scholar 

  • Honma, Y., Kasukabe, T., Okabe, J., Hozumi, M.: Prolongation of survival time of mice inoculated with myeloid leukemia cells by inducers of normal differentiation. Cancer Res. 39, 3167–3171 (1979).

    PubMed  CAS  Google Scholar 

  • Housman, D., Gusella, J., Geller, R., Levenson, R., Weil, S.: Differentiation of murine erythroleukemia cells: the control role of the commitment event. in: Differentiation of normal and neoplastic hematopoietic cells. Clarkson, B., Marks, P., Till, J. (eds.), pp. 193–207. New York: Cold Spring Harbor 1978.

    Google Scholar 

  • Huberman, E., Callahan, M.F.: Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents. Proc. Natl. Acad. Sci. U.S.A. 76, 1293–1297 (1979).

    PubMed  CAS  Google Scholar 

  • Ichikawa, Y.: Differentiation of a cell line of mouse myeloid leukemia. J. Cell. Physiol. 74, 223–234 (1969).

    PubMed  CAS  Google Scholar 

  • Ikawa, Y., Aida, M., Inoue, Y.: Isolation and characterization of high and low differentiation-inducible Friend leukemia lines. Gann 67, 767–770 (1976a).

    PubMed  CAS  Google Scholar 

  • Ikawa, Y., Inoue, A., Aida, M., Kameji, R., Shibata, C., Sugano, H.: Phenotypic variants of differentiation-inducible Friend leukemia lines: Isolation and correlation between inducibility and virus release. Bibl. Haematol. 43, 37–47 (1976b).

    Google Scholar 

  • Keppel, F., Allet, B., Eisen, H.: Appearance of a chromatin protein during the erythroid differentiation of Friend virus transformed cells. Proc. Natl. Acad. Sci. U.S.A. 74, 653–656 (1977).

    PubMed  CAS  Google Scholar 

  • Koeffler, H.P., Bar-Eli, M., Territo, M.: Heterogeneity of human myeloid leukemia cell response to phorbol diester. Blood 54, (Suppl. 1), 174 a (1979).

    Google Scholar 

  • Krystosek, A., Sachs, L.: Control of lysozyme induction in the differentiation of myeloid leukemic cells. Cell 9, 675–684 (1976).

    PubMed  CAS  Google Scholar 

  • Lacour, F., Harel, L., Friend, C., Huynh, T., Holland, J.G.: Induction of differentiation of murine erythroleukemia cells by aminonucleoside of puromycin and its inhibition by purines and purine derivatives. Proc. Natl. Acad. Sci. U.S.A. 77, 2740–2742 (1980).

    PubMed  CAS  Google Scholar 

  • Leder, A., Leder, P.: Butyric acid: a potent inducer of erythroid differentiation in cultured erythroleukemia cells. Cell 5, 319–322 (1975).

    PubMed  CAS  Google Scholar 

  • Leder, A., Orkin, S., Leder, P.: Differentiation of erythroleukemia cells in the presence of inhibitors of DNA synthesis. Science 190, 893–894 (1975).

    PubMed  CAS  Google Scholar 

  • Levenson, R., Kernen, J., Mitrani, A., Housman, D.: DNA synthesis is not required for the commitment of murine erythroleukemia cells. Devel. Biol. 74, 224–230 (1980).

    CAS  Google Scholar 

  • Levy, J., Terada, M., Rifkind, R.A., Marks, P.A.: Induction of erythroid differentiation in Friend virus infected cells by dimethylsulfoxide: relationship to the cell cycle. Proc. Natl. Acad. Sci. U.S.A. 72, 28–32 (1975).

    PubMed  CAS  Google Scholar 

  • Lo, S.C., Aft, R., Ross, F., Mueller, G.C.: Control of globin gene expression by steroid hormones in differentiating Friend leukemia cells. Cell 15, 447–453 (1978).

    PubMed  CAS  Google Scholar 

  • Lotem, J., Sachs, L.: Different blocks in the differentiation of myeloid leukemic cells. Proc. Natl. Acad. Sci. U.S.A. 71, 3507–3511 (1974).

    PubMed  CAS  Google Scholar 

  • Lotem, J., Sachs, L.: Induction of specific changes in the surface membrane of myeloid leukemic cells by steroid hormones. Int. J. Cancer 15, 731–740 (1975a).

    PubMed  CAS  Google Scholar 

  • Lotem, J., Sachs, L.: Control of normal differentiation of myeloid leukemic cells. VI. Inhibition of cell multiplication and the formation of macrophages. J. Cell. Physiol. 85, 587–596 (1975b).

    PubMed  CAS  Google Scholar 

  • Lotem, J., Sachs, L.: Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion. Proc. Natl. Acad. Sci. U.S.A. 76, 5158–5162 (1979).

    PubMed  CAS  Google Scholar 

  • Lozzio, C.B., Lozzio, B.B.: Human chronic myelogenous leukemic cell line with positive Philadelphia chromosome. Blood 45, 321–334 (1975).

    PubMed  CAS  Google Scholar 

  • Mager, D.L., MacDonald, M.E., Bernstein, A.: Growth in high-K+ medium induces Friend cell differentiation. Devel. Biol. 70, 268–273 (1979).

    CAS  Google Scholar 

  • Marks, P.A., Rifkind, R.A.: Erythroleukemic differentiation. Ann. Rev. Biochem. 47, 419–448 (1978).

    PubMed  CAS  Google Scholar 

  • Matarese, G.P., Rossi, G.B.: Effect of interferon on growth and division cycle of Friend erythroleukemic murine cells in vitro. J. Cell Biol. 75, 344–354 (1977).

    PubMed  CAS  Google Scholar 

  • McClintock, P.R., Papaconstantinou, J.: Regulation of hemoglobin synthesis in a murine erythroblastic leukemic cell: the requirement for replication to induce hemoglobin synthesis. Proc. Natl. Acad. Sci. U.S.A. 71, 4551–4555 (1974).

    PubMed  CAS  Google Scholar 

  • Metcalf, D.: Haemopoietic colonies. Recent Res. Cancer Res. 61, 1–213 (1977).

    Google Scholar 

  • Metcalf, D., Moore, M.A.S.: Haemopoietic cells. Amsterdam: North Holland 1971.

    Google Scholar 

  • Miao, R.M., Fieldsteel, A.H.: Regulation of erythroid differentiation: characterization of Rauscher and Friend virus-transformed proerythroid cells. Proc. Soc. Exp. Biol. Med. 160, 24–27 (1979).

    PubMed  CAS  Google Scholar 

  • Miao, R.M., Fieldsteel, A.M., Fodge, D.W.: Opposing effects of tumor promoters on erythroid differentiation. Nature 274, 271–272 (1978).

    PubMed  CAS  Google Scholar 

  • Moore, M.A.S.: Regulation of leukocyte differentiation and leukemia as a disorder of differentiation. In: Recent advances in cancer research: Cell biology and tumor virology. Gallo, R.C. (ed.). pp. 79–103. Cleveland: CRC Press 1977.

    Google Scholar 

  • Moore, M.A.S., Kurland, J., Broxmeyer, H.E.: Regulatory interactions in normal and leukemic myelopoiesis. in: Differentiation of normal and neoplastic hematopoietic cells. Clarkson, B., Marks, P. and Till, J. (eds.), pp. 393–404. New York: Cold Spring Harbor 1978.

    Google Scholar 

  • Nakayasu, M., Terada, M., Tamura, G., Sugimura, T.: Induction of differentiation of human and murine myeloid leukemia cells in culture by tunicamycin. Proc. Natl. Acad. Sci. U.S.A. 77, 400–413 (1980).

    Google Scholar 

  • Ohta, Y., Tanaka, M., Terada, M., Miller, O.J., Bank, A., Marks, P.A., Rifkind, R.A.: Erythroid cell differentiation: murine erythroleukemia cell variant with unique pattern of induction by polar compounds. Proc. Natl. Acad. Sci. U.S.A. 73, 1232–1236 (1976).

    PubMed  CAS  Google Scholar 

  • Okabe, J., Honma, Y., Hozumi, M.: Differentiation of a resistant clone of mouse myeloid leukemia cells with dimethyl sulfoxide and ascitic fluid. Gann 68, 151–157 (1977).

    PubMed  CAS  Google Scholar 

  • Okabe, J., Honma, Y., Hayashi, M., Hozumi, M.: Actinomycin D restores in vivo sensitivity to differentiation induction of non-differentiating mouse myeloid leukemia cells. Int. J. Cancer 24, 87–91 (1979).

    PubMed  CAS  Google Scholar 

  • Papac, R.J., Browna, A.E., Sartorelli, A.C.: Induction of differentiation of human myeloid cells in vitro by 6-thioguanine. Proc. Am. Soc. Clin. Oncol. 20, 419 (1979).

    Google Scholar 

  • Patuleia, M.C., Friend, C.: Tissue culture studies on murine virus induced leukemia cells: isolation of single cells in agar liquid medium. Cancer Res. 27, 726–730 (1967).

    Google Scholar 

  • Paul, J., Hickey, I.: Hemoglobin synthesis in inducible, uninducible and hybrid Friend cell clones. Exp. Cell Res. 87, 20–30 (1974).

    PubMed  CAS  Google Scholar 

  • Pegoraro, L., Abrahm, J., Cooper, R.A., Levis, A., Lange, B., Meo, P., Rovera, G.: Differentiation of human leukemias in response to 12-O-tetradecanoyl-phorbol-13-acetate in vitro. Blood 55, 859–862 (1980).

    PubMed  CAS  Google Scholar 

  • Preisler, H.D., Giladi, M.: Differentiation of erythroleukemic cells in vitro: irreversible induction by dimethyl sulfoxide. J. Cell. Physiol. 85, 537–545 (1975).

    PubMed  CAS  Google Scholar 

  • Preisler, H.D., Lyman, G.: Differentiation of erythroleukemic cells in vitro: Properties of chemical inducers. Cell Differ. 4, 179–185 (1975).

    PubMed  CAS  Google Scholar 

  • Preisler, H.D., Housman, D., Scher, W., Friend, C.: Effects of 5-Bromo-2′-deoxyuridine on production of globin messenger RNA in dimethyl sulfoxide-stimulated Friend leukemia cells. Proc. Natl. Acad. Sci. U.S.A. 70, 2956–2959 (1973).

    PubMed  CAS  Google Scholar 

  • Preisler, H.D., Bjornsson, S., Mori, M., Lyman, G.H.: Inducers of Friend leukemia cell differentiation in vitro — effects of in vivo administration. Br. J. Cancer 33, 634–645 (1976 a).

    PubMed  CAS  Google Scholar 

  • Preisler, H.D., Christoff, G., Taylor, E.: Cryoprotective agents as inducers of erythroleukemic cell differentiation in vitro. Blood 47, 363–368 (1976b).

    PubMed  CAS  Google Scholar 

  • Preisler, H.D., Shiraishi, Y., Mori, M., Sandberg, A.A.: Clones of Friend leukemia cells: differences in karyotypes and responsiveness to inducers of differentiation. Cell Differ. 5, 207–216 (1976 c).

    PubMed  CAS  Google Scholar 

  • Quesenberry, P., Levitt, L.: Hematopoietic stem cells. New Engl. J. Med. 301, 755–760 (1979a).

    PubMed  CAS  Google Scholar 

  • Quesenberry, P., Levitt, L.: Hematopoietic stem cells. New Engl. J. Med. 301, 819–823 (1979b).

    PubMed  CAS  Google Scholar 

  • Quesenberry, P., Levitt, L.: Hematopoietic stem cells. New Engl. J. Med. 301, 868–872 (1979 c).

    PubMed  CAS  Google Scholar 

  • Reuben, R.C., Wife, R.L., Breslow, R., Rifkind, R.A., Marks, P.A.: Identification of a new group of potent inducers of differentiation in murine erythroleukemia cells. Proc. Natl. Acad. Sci. U.S.A. 73, 862–866 (1976).

    PubMed  CAS  Google Scholar 

  • Reuben, R.C., Khanna, P.L., Gazitt, Y., Breslow, R., Rifkind, R.A., Marks, P.A.: Inducers of erythroleukemic differentiation. J. Biol. Chem. 253, 4214–4218 (1978).

    PubMed  CAS  Google Scholar 

  • Ross, J., Sautner, D.: Induction of globin mRNA accumulation by heme in cultured erythroleukemic cells. Cell 8, 513–520 (1976).

    PubMed  CAS  Google Scholar 

  • Rossi, G.B., Dolei, A., Cioe, L., Benedetto, A., Matarese, G.P., Belardelli, F.: Inhibition of transcription and translation of globin messenger RNA in dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated with interferon. Proc. Natl. Acad. Sci. U.S.A. 74, 2036–2040 (1977a).

    PubMed  CAS  Google Scholar 

  • Rossi, G.B., Matarese, G.P., Grappelli, C., Belardelli, F.: Interferon inhibits dimethyl sulfoxide-induced erythroid differentiation of Friend leukaemia cells. Nature 267, 50–52 (1977b).

    PubMed  CAS  Google Scholar 

  • Rovera, G., Bonaiuto, J.: The phenotypes of variant clones of Friend mouse erythroleukemic cells resistant to dimethylsulfoxide. Cancer Res. 36, 4057–4061 (1976).

    PubMed  CAS  Google Scholar 

  • Rovera, G., Surrey, S.: Isolation and characterization of a subline of Friend erythroleukemia cells that differentiate in tissue culture in the absence of inducers. Cancer Res. 37, 4211–4219 (1977).

    PubMed  CAS  Google Scholar 

  • Rovera, G., Surrey, S.: Use of resistant or hypersensitive variant clones of Friend cells in analysis of the mode of action of inducers. Cancer Res. 38, 3737–3744 (1978).

    PubMed  CAS  Google Scholar 

  • Rovera, G., O’Brien, T., Diamond, L.: Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture. Proc. Natl. Acad. Sci. U.S.A. 74, 2894–2898 (1977).

    PubMed  CAS  Google Scholar 

  • Rovera, G., O’Brien, T.G., Diamond, L.: Induction of differentiation in human promyelocytic leukemia cells by tumor promoters. Science 204, 868–870 (1979a).

    PubMed  CAS  Google Scholar 

  • Rovera, G., Santoli, D., Damsky, C.: Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with phorbol diesters. Proc. Natl. Acad. Sci. U.S.A. 76, 2779–2783 (1979b).

    PubMed  CAS  Google Scholar 

  • Rovera, G., Olashaw, N., Meo, P.: Terminal differentiation in human promyelocytic leukemic cells in the absence of DNA synthesis. Nature 284, 69–70 (1980).

    PubMed  CAS  Google Scholar 

  • Rutherford, T.R., Clegg, J.B., Weatherall, D.J.: K 562 human leukemic cells synthesize embryonic hemoglobin in response to hemin. Nature 280, 164–165 (1979).

    PubMed  CAS  Google Scholar 

  • Sachs, L.: Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemia. Nature 274, 535–539 (1978).

    PubMed  CAS  Google Scholar 

  • Santoro, M.G., Benedetto, A., Jaffe, B.M.: Hydrocortisone inhibits DMSO-induced differentiation of Friend erythroleukemia cells. Biochem. Biophys. Res. Commun. 85, 1510–1518 (1978).

    PubMed  CAS  Google Scholar 

  • Scher, W., Friend, C.: Breakage of DNA and alterations in folded genomes by inducers of differentiation in Friend erythroleukemic cells. Cancer Res. 38, 841–849 (1978).

    PubMed  CAS  Google Scholar 

  • Scher, W., Preisler, H.D., Friend, C.: Hemoglobin synthesis in murine virus-induced leukemic cells in vitro. Effect of 5-bromodeoxyuridine, dimethyl formamide and dimethyl sulfoxide. J. Cell. Physiol. 81, 63–79 (1973).

    CAS  Google Scholar 

  • Scher, W., Tsuei, D., Sassa, S., Price, P., Gabelman, N., Friend, C.: Inhibition of DMSO-stimulated Friend cell erythrodifferentiation by hydrocortisone and other steroids. Proc. Natl. Acad. Sci. U.S.A. 75, 3851–3855 (1978).

    PubMed  CAS  Google Scholar 

  • Selonick, S.E., Breitman, T.R., Collins, S.J.: Retinoic acid induces differentiation of the human promyelocytic leukemic cell line (HL 60). Proc. Am. Fed. Clin. Res. 180 a (1980).

    Google Scholar 

  • Silagi, S., Bruce, S.A.: Suppression of malignancy and differentiation in melanotic melanoma cells. Proc. Natl. Acad. Sci. U.S.A. 66, 72–78 (1970).

    PubMed  CAS  Google Scholar 

  • Stockdale, F., Okazaki, K., Nameroff, M., Holtzer, H.: 5-bromodeoxy-uridine: effect on myogenesis in vitro. Science 146, 533–535 (1964).

    PubMed  CAS  Google Scholar 

  • Stuart, R.K., Hamilton, J.: Tumor promoting phorbol esters stimulate hemopoietic colony formation in vitro. Blood 54 (Suppl. 1) 176a (1979).

    Google Scholar 

  • Sugano, H., Furusawa, M., Kawaguchi, T., Ikawa, Y.: Enhancement of erythrocytic maturation of Friend virus induced leukemic cells in vitro. Bibl. Hematol. 39, 943–954 (1973).

    CAS  Google Scholar 

  • Tabuse, Y., Furasawa, M., Eisen, H., Shibata, K.: Prostaglandin E1, and inducer of erythroid differentiation of Friend erythroleukemia cells. Exp. Cell Res.108, 41–45 (197

    PubMed  CAS  Google Scholar 

  • Takahashi, E., Yamada, M., Saito, M., Kuboyama, M., Ogasa, K.: Differentiation of cultured Friend leukemic cells induced by short-chain fatty acids. Gann 66, 577–580 (1975).

    PubMed  CAS  Google Scholar 

  • Tanaka, M., Levy, J., Terada, M., Breslow, R., Rifkind, R.A., Marks, P.A.: Induction of erythroid differentiation in murine virus infected erythroleukemia cells by highly polar compounds. Proc. Natl. Acad. Sci. U.S.A. 72, 1003–1006 (1975).

    PubMed  CAS  Google Scholar 

  • Terada, M., Epner, E., Nudel, U., Salmon, J., Fibach, E., Rifkind, R.A., Marks, P.A.: Induction of murine erythroleukemia differentiation by Actinomycin D. Proc. Natl. Acad. Sci. U.S.A. 75, 2795–2799 (1978 a).

    PubMed  CAS  Google Scholar 

  • Terada, M., Marks, P.A., Rifkind, R.A.: Erythroid cell differentiation. Mol. Cell. Biochem. 21, 33–41 (1978 b).

    PubMed  CAS  Google Scholar 

  • Terada, M., Nudel, U., Fibach, E., Rifkind, R.A., Marks, P.A.: Changes in DNA associated with induction of erythroid differentiation by dimethyl sulfoxide in murine erythroleukemia cells. Cancer Res. 38, 835–840 (1978 c).

    PubMed  CAS  Google Scholar 

  • Terada, M., Fujiki, H., Marks, P.A., Sugimura, T.: Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds. Proc. Natl. Acad. Sci. U.S.A. 76, 6411–6414 (1979).

    PubMed  CAS  Google Scholar 

  • Till, J.E., McCulloch, E.A., Siminovitch, L.: A stochastic model of stem cell proliferation based on the growth of spleen colony-forming cells. Proc. Natl. Acad. Sci. U.S.A. 51, 29–36 (1964).

    PubMed  CAS  Google Scholar 

  • Tomida, M., Yamamoto, Y., Hozumi, M.: Induction by synthetic polyribonucleotide Poly (I) of differentiation of cultured mouse myeloid leukemia cells. Cell Differ. 7, 305–312 (1978).

    PubMed  CAS  Google Scholar 

  • Tsiftsoglou, A.S., Gusella, J.F., Volloch, V., Housman, D.E.: Inhibition by dexamethasone of commitment to erythroid differentiation in murine erythroleukemia cells. Cancer Res. 39, 3849–3855 (1979).

    PubMed  CAS  Google Scholar 

  • Weiss, B., Sachs, L.: Indirect induction of differentiation in myeloid leukemic cells by lipid A. Proc. Natl. Acad. Sci. U.S.A. 75, 1374–1378 (1978).

    PubMed  CAS  Google Scholar 

  • Whang, J., Frei, E. III, Tjio, J.H., Carbone, P.C., Brecher, G.: The distribution of the Philadelphia chromosome in patients with chronic myeloid leukemia. Blood 22, 664–673 (1963).

    PubMed  CAS  Google Scholar 

  • Wiens, A.W., McClintock, P.R., Papaconstantinou, J.: The dependence of erythroid differentiation on cell replication in dimethyl sulfoxide treated Friend leukemia virus infected cells. Biochem. Biophys. Res. Commun. 70, 824–831 (1976).

    PubMed  CAS  Google Scholar 

  • Yamasaki, H., Fibach, E., Weinstein, I.B., Nudel, U., Rifkind, R.A., Marks, P.A.: Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture. Proc. Natl. Acad. Sci. U.S.A. 74, 3451–3455 (1977).

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Janet Abrahm
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Rovera
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Fels Research Institute and Department of Pathology, Temple University School of Medicine, Health Sciences Center, Philadelphia, PA, 19140, USA

    Renato Baserga M.D. (Senior Investigator) (Senior Investigator)

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Abrahm, J., Rovera, G. (1981). Inducers and Inhibitors of Leukemic Cell Differentiation in Culture. In: Baserga, R. (eds) Tissue Growth Factors. Handbook of Experimental Pharmacology, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67986-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67986-5_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67988-9

  • Online ISBN: 978-3-642-67986-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation