Inhibition of Hematopoietic Cell Proliferation
In healthy post-natal human beings, hematopoiesis is restricted to the bone marrow. As mature blood cells are utilized or die in the periphery, they are continuously replenished by the bone marrow. For years, it has been recognized that blood cell renewal is accomplished by maturation of morphologically identifiable precursors (blast cells) in the bone marrow. More recently, with the development of hematopoietic cell culture techniques, the concept has evolved that these morphologically recognizable precursor cells are in turn replenished from hematopoietic stem cells. In this hierarchical scheme of hematopoiesis, hematopoietic stem cells have the dual capacities of self-renewal and differentiation; that is, they are capable both of maintaining their own numbers and of giving rise to progeny committed to a single line of differentiation. A model of hematopoiesis based on this scheme is depicted in Fig. 1.
KeywordsAgar Leukemia Cortisol Anemia Fractionation
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