Inhibition of Hematopoietic Cell Proliferation

  • J. H. Fitchen
  • M. J. Cline
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 57)


In healthy post-natal human beings, hematopoiesis is restricted to the bone marrow. As mature blood cells are utilized or die in the periphery, they are continuously replenished by the bone marrow. For years, it has been recognized that blood cell renewal is accomplished by maturation of morphologically identifiable precursors (blast cells) in the bone marrow. More recently, with the development of hematopoietic cell culture techniques, the concept has evolved that these morphologically recognizable precursor cells are in turn replenished from hematopoietic stem cells. In this hierarchical scheme of hematopoiesis, hematopoietic stem cells have the dual capacities of self-renewal and differentiation; that is, they are capable both of maintaining their own numbers and of giving rise to progeny committed to a single line of differentiation. A model of hematopoiesis based on this scheme is depicted in Fig. 1.


Colony Formation Aplastic Anemia Chronic Myelogenous Leukemia Human Bone Marrow Bone Marrow Failure 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • J. H. Fitchen
  • M. J. Cline
    • 1
    • 2
  1. 1.Department of Medicine, Center for the Health SciencesUniversity of CaliforniaLos AngelesUSA
  2. 2.Wadsworth Veterans Administration HospitalLos AngelesUSA

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