Abstract
The search to determine if retroviruses cause human leukemia has now been underway for at least 15 years. However, the number of investigators who have conducted direct studies with human materials has been small. By contrast, major emphasis has been given to the study of retrovirus-induced tumors of inbred mice and chickens as models for understanding leukemia of man. At the same time only a limited amount of attention has ben given to the study of the agents that are known to cause leukemia in cats and cattle. Having evolved under natural circumstances in outbred species, the feline and bovine retroviruses would appear to be important agents for study. Presumably information derived about potential mechanisms of leukemogenesis in these species would be applicable to many of the questions one might pose about the etiology of human leukemia. In this context we describe recent findings on the biology and natural history of the feline retroviruses and the diseases they cause.
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Chen AP, Essex M, Mikami T, Albert D, Niederkorn JY, Shadduck JP (1980) The expression of transformation-related proteins in cat cells. In: Hardy WD Jr, Essex M, McClelland J (eds) Feline leukemia and sarcoma viruses. Elsevier, New York pp 441–456
Cotter SM, Gilmore CE, Rollins C (1973) Multiple cases of feline leukemia and feline infectious peritonitis in a household. J Am Vet Med Assoc 162:1054–1058
Cotter SM, Essex M, McLane MF, Grant CK, Hardy WD Jr (1980) Passive immunotherapy in naturally occurring feline mediastinal lymphoma. In: Hardy WD Jr, Essex M, McClelland J (eds) Feline leukemia and sarcoma viruses. Elsevier, New York pp 219–226
Essex M (1975) Horizontally and vertically transmitted oncornaviruses of cats. Adv Cancer Res 21:175–248
Essex M (1980) Feline leukemia and sarcoma viruses. In: Klein G (ed) Viral oncology. Raven, New York, pp 205–229
Essex M, Klein G, Snyder SP, Harrold JB (1971) Feline sarcoma virus (FSV) induced tumors: correlations between humoral antibody and tumor regression. Nature 233:195–196
Essex M, Hardy WD Jr, Cotter SM, Jakowski RM, Sliski A (1975a) Naturally occurring persistent feline oncornavirus infections in the absence of disease. Infect Immun 11:470–475
Essex M, Sliski A, Cotter SM, Jakowski RM, Hardy WD Jr (1975b) Immunosurveillance of naturally occurring feline leukemia. Science 190:790–792
Essex M, Cotter SM, Sliski AH, Hardy WD Jr, Stephenson JR, Aaronson SA, Jarrett O (1977) Horizontal transmission of feline leukemia virus under natural conditions in a feline leukemia cluster household. Int J Cancer 19:90–96
Essex M, Sliski AH, Hardy WD Jr, de Noronha F, Cotter SM (1978) Feline oncornavirus associated cell membrane antigen: a tumor specific cell surface marker. In: Bentvelzen P, Hilgers J, Yohn DS (eds) Advances in comparative leukemia research 1977. Elsevier/North Holland Biomedical Press, Amsterdam, pp 337–340
Francis DP, Essex M, Hardy WD Jr (1977) Excretion of feline leukemia virus by naturally infected pet cats. Nature 269:252–254
Francis DP, Cotter SM, Hardy WD Jr, Essex M (1979a) Comparison of virus-positive and virus-negative cases of feline leukemia and lymphoma. Cancer Res 39:3866–3870
Francis DP, Essex M, Cotter SM, Jakowski RM, Hardy WD Jr (1979b) Feline leukemia virus infections: the significance of chronic viremia. Leuk Res 3:435–441
Francis DP, Essex M, Gayzagian D (1979c) Feline leukemia virus: survival under home and laboratory conditions. J Clin Microbiol 9:154–156
Francis DP, Essex M, Jakowski RM, Cotter SM, Lerer TJ, Hardy WD Jr (1980) Feline lymphoma: descriptive epidemiology of a virally-induced malignancy in a closed cat population. Am J Epidemiol 111:337–346
Frankel AE, Gilbert JH, Porzig KJ, Scolnick EM, Aaronson SA (1979) Nature and distribution of feline sarcoma virus nucleotide sequences. J Virol 30:821–827
Grant CK, De Boer DJ, Essex M, Worley MB, Higgins J (1977) Antibodies from healthy cats exposed to feline leukemia virus lyse feline lymphoma cells slowly with cat complement. J Immunol 119:401–406
Grant CK, Essex M, Pedersen NC, Hardy WD Jr, Cotter SM, Theilen GH (1978) Cat complement and cat antisera lyse feline lymphoblastoid cells: Correlation of lysis with detection of antibodies to FOCMA. J Natl Cancer Inst 60:161–166
Grant CK, Ramaika C, Madewell BR, Pickard DK, Essex M (1979) Complement and tumor antibody levels in cats, and changes associated with natural feline leukemia virus infection and malignant disease. Cancer Res 39:75–81
Grant CK, Essex M, Gardner MB, Hardy WD Jr (1980) Natural feline leukemia virus infection and the immune response of cats of different ages. Cancer Res 40:825–829
Hardy WD Jr, Old LJ, Hess PW, Essex M, Cotter SM (1973) Horizontal transmission of feline leukemia virus in cats. Nature 244:266–269
Hardy WD Jr, McClelland AJ, Zuckerman EE, Hess PW, Essex M, Cotter SM, MacEwen EG, Hayes AA (1976) Prevention of the infectious spread of the feline leukemia virus in pet cats. Nature 263:326–328
Hardy WD Jr, Zuckerman EE, MacEwen EG, Hayes AA, Essex M (1977) A feline leukemia and sarcoma virus induced tumor specific antigen. Nature 270:249–251
Hardy WD Jr, Zuckerman EE, McClelland AJ, Snyder HW Jr, Essex M, Francis DP (1980) The immunology and epidemiology of FeLV nonproducer feline lymphosarcoma. Cold Spring Harbor Conf Cell Prolif 7:677–697
Hoover EA, Olsen RG, Hardy WD Jr, Schaller JP, Mathes LE (1976) Feline leukemia virus infecton: age-related variation in response of cats to experimental infection. J Natl Cancer Inst 57:365–370
Mackey L, Jarrett W, Jarrett O, Laird H (1975) Anemia associated with feline leukemia virus infection in cats. J Natl Cancer Inst 54:209–218
Niederkorn JY, Shadduck JA, Albert D, Essex M (1980) FOCMA antibodies in cats with FeSV-induced ocular melanomas. In: Hardy WD Jr, Essex M, McClelland J (eds) Feline leukemia and sarcoma viruses. Elsevier, New York pp 181–186
Noronha F de, Grant CK, Essex M, Bolognesi DP (to be published) Passive immune serotherapy protects cats from disseminated FeSV-induced fibrosarcomas. In: Hardy WD Jr, Essex M, McClelland J (eds) Feline leukemia and sarcoma viruses. Elsevier/North Holland, New York
Porzig KJ, Barbacid M, Aaronson SA (1979) Biological properties and translational products of three independent isolates of feline sarcoma virus. Virology 92:91–107
Rosenberg ZF, Pedersen FS, Haseltine WA (1980) Comparative analysis of the genome of feline leukemia viruses. J Virol 35:542–546
Russell PH, Jarrett O (1978) The occurrence of feline leukemia virus neutralizing antibodies in cats. Int J Cancer 22:351–357
Sarma PS, Log T (1973) Subgroup classification of feline leukemia and sarcoma viruses by viral interference and neutralization tests. Virology 54:160–170
Sherr CJ, Sen A, Todaro GJ, Sliski AH, Essex M (1978) Pseudotypes of feline sarcoma virus contain an 85,000 dalton protein with feline oncornavirus-associated cell membrane antigen (FOCMA) activity. Proc Natl Acad Sci USA 75:1505–1509
Sliski AH, Essex M, Meyer C, Todaro GJ (1977) Feline oncornavirus associated cell membrane antigen (FOCMA): expression on feline sarcoma virus transformed nonproducer mink cells. Science 196:1336–1339
Snyder HW Jr, Hardy WD Jr, Zuckerman EE, Fleissner E (1978) Characterization of a tumour-specific antigen on the surface of feline lymphosarcoma cells. Nature 175:656–657
Snyder HW Jr, Phillips KJ, Hardy WD Jr, Zuckerman EE, Essex M, Sliski AH, Rhim J (1980) Isolation and characterization of proteins carrying the feline oncornavirus-associated cell membrane antigen (FOCMA). Cold Spring Harbor Symp Quant Biol 44:878–899
Stephenson JR, Essex M, Hino S, Aaronson SA, Hardy WD Jr (1977a) Feline oncornavirus-associated cell membrane antigen. VII. Relationship between FOCMA and virion glycoprotein gp70. Proc Natl Acad Sci USA 74:1219–1223
Stephenson JR, Khan AS, Sliski AH, Essex M (1977b) Feline oncornavirus-associated cell membrane antigen (FOCMA): identification of an immunologically cross-reactive feline sarcoma virus coded protein. Proc Natl Acad Sci USA 74:5608–5612
Worley M, Essex M (1980) Identification of membrane proteins associated with transformation-related antigens shared by feline lymphoma cells and feline sarcoma virus transformed fibroblasts. In: Hardy WD Jr, Essex M, McClelland J (eds) Feline leukemia and sarcoma viruses. Elsevier, New York pp 431–440
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Essex, M., Grant, C.K., Cotter, S.M., Hardy, W.D. (1981). Role of Viruses in the Etiology of Naturally Occurring Feline Leukemia. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K., Winkler, K. (eds) Modern Trends in Human Leukemia IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67984-1_88
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DOI: https://doi.org/10.1007/978-3-642-67984-1_88
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