Acute Leukemia and Nonspecific Killer Cells

  • J. Milleck
  • P. Jantscheff
  • H. Thränhardt
  • M. Schöntube
  • R. Gürtler
  • D. Seifart
  • G. Pasternak
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 26)

Abstract

This paper is to give a contribution to two aspects of the study of leukemia: functional characterization of human leukemia cells and cellular mechanisms leading to the killing of leukemia cells. Considering that some populations of nonmatured lymphocytic and myelolytic cells are natural killer (NK) cells or effectors of the antibody-dependent cellular cytotoxicity (K cells), we have been looking for these effector cells in patients suffering from acute lymphoblastic leukemia (ALL) or acute nonlymphoblastic leukemia (ANLL). In cases with high leukemic blast counts the possibility of detection of leukemic NK or K cells may exist. Since animal experiments indicate a bone marrow origin of non-specific killer cells, we directly compared effector cell activities of mononuclear blood leukocytes (PBL) and bone marrow (BM) cells.

Keywords

Leukemia Interferon Abate Estima 

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References

  1. Milleck J, Karsten U, Eckert R, Dörffel W, Thränhardt H, Pasternak G (1978) Antibody-dependent cellular cytotoxicity in experimental and human leukemia. In: Rainer H (ed) Immunotherapy of malignant diseases. Schattauer, Stuttgart New York, pp 323–326Google Scholar
  2. Schmidt P, Peter HH, Kalden JR, Avenarius HJ, Bodenstein H (1978) Effektorfunktion akuter Leukämiezellen in “spontanen” (SCMC) und Antikörper abhängigen zellulären Zytotoxizitätstesten (ADCC). Klin Wochenschr 56:953–962PubMedCrossRefGoogle Scholar
  3. Zarling JM, Eskra L, Borden EC, Horoszewicz J, Carter WA (1979) Activation of human natural killer cells cytotoxic for human leukemia cells by purified interferon. J Immunol 123:63–70PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • J. Milleck
  • P. Jantscheff
  • H. Thränhardt
  • M. Schöntube
  • R. Gürtler
  • D. Seifart
  • G. Pasternak

There are no affiliations available

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