Human Leucocyte Antigens
The analysis of leucocyte differentiation has been facilitated by developments in two areas of methodology: firstly, by the ability to identify and separate by surface markers cells of different lineages and stages of differentiation, and secondly, by the introduction of new functional assays, both for haemopoietic progenitor cells and mature leucocytes. In humans the production of monoclonal antibodies by somatic cell hybridisation has provided many markers for human leucocytes, whereas previously there was a paucity of reliable antisera.
KeywordsHuman Leucocyte Antigen Medullary Cell Peripheral Blood Mononuclear Bone Marrow Progenitor Cell Human Bone Marrow Culture
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- Beverley PCL (1980) Production and use of monoclonal antibodies in transplantation immunology. In: Touraine JL, Traeger J, Betuel H, Brochier J, Dubernard JM, Revillard JP, Triau R (eds) Transplantation and clinical immunology, vd XI. Excerpta Medica, Amsterdam, pp 87–94Google Scholar
- Bom-van Noorloos AA, Pegels HG, van Oers RJJ, Silberbusch J, Feltkamp-Vroom TM, Goudsmit R, Zeijlemaker WP, von dem Borne AEG, Melief CJM (1980) Proliferation of Tγ cells with killer-cell activity in two patients with neutropenia and recurrent infections. N Engl J Med 302:933–937PubMedCrossRefGoogle Scholar
- Bradstock KF, Janossy G, Pizzolo G, Hoffbrand AV, McMichael A, Pilch JR, Milstein C, Beverley PCL, Bollum FJ (to be published) Subpopulations of normal and leukaemic human thymocytes: An analysis with the use of monoclonal antibodies. J Natl Cancer InstGoogle Scholar
- Iscove N (1978) Regulation of proliferation and maturation at early and late stages of erythroid differentiation. In: Saunders GF (ed) Cell differentiation and neoplasia. New York, Raven, pp 195–209Google Scholar
- Kaszubowksi PA, Goodwin JS, Williams RC (1980) Ia antigen on the surface of a subfraction of T cells that bear Fc receptors for IgG. J Immunol 124:1075–1078Google Scholar