Human Leucocyte Antigens

  • P. C. L. Beverley
  • D. Linch
  • R. E. Callard
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 26)


The analysis of leucocyte differentiation has been facilitated by developments in two areas of methodology: firstly, by the ability to identify and separate by surface markers cells of different lineages and stages of differentiation, and secondly, by the introduction of new functional assays, both for haemopoietic progenitor cells and mature leucocytes. In humans the production of monoclonal antibodies by somatic cell hybridisation has provided many markers for human leucocytes, whereas previously there was a paucity of reliable antisera.


Human Leucocyte Antigen Medullary Cell Peripheral Blood Mononuclear Bone Marrow Progenitor Cell Human Bone Marrow Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Beverley PCL (1980) Production and use of monoclonal antibodies in transplantation immunology. In: Touraine JL, Traeger J, Betuel H, Brochier J, Dubernard JM, Revillard JP, Triau R (eds) Transplantation and clinical immunology, vd XI. Excerpta Medica, Amsterdam, pp 87–94Google Scholar
  2. Bom-van Noorloos AA, Pegels HG, van Oers RJJ, Silberbusch J, Feltkamp-Vroom TM, Goudsmit R, Zeijlemaker WP, von dem Borne AEG, Melief CJM (1980) Proliferation of Tγ cells with killer-cell activity in two patients with neutropenia and recurrent infections. N Engl J Med 302:933–937PubMedCrossRefGoogle Scholar
  3. Bradstock KF, Janossy G, Pizzolo G, Hoffbrand AV, McMichael A, Pilch JR, Milstein C, Beverley PCL, Bollum FJ (to be published) Subpopulations of normal and leukaemic human thymocytes: An analysis with the use of monoclonal antibodies. J Natl Cancer InstGoogle Scholar
  4. Brodsky FM, Parham P, Barnstaple CJ, Crumpton MJ, Bodmer WF (1979) Monoclonal antibodies for analysis of the HLA system. Immunol Rev 47:3–62PubMedCrossRefGoogle Scholar
  5. Burgess AW, Wilson EMA, Metcalf D (1977) Stimulation by human placental conditioned medium of hemopoietic colony formation by human marrow cells. Blood 49:573–583PubMedGoogle Scholar
  6. Callard RE (1979) Specific in vitro antibody response to influenza virus by human blood lymphocytes. Nature 282:734–736PubMedCrossRefGoogle Scholar
  7. Cooper MD (1980) Immunologic analysis of lymphoid tumours. N Engl J Med 302:964–965PubMedCrossRefGoogle Scholar
  8. Greaves MF, Janossy G (1978) Patterns of gene expression and the cellular origins of human leukaemias. Biochim Biophys Acta 516:193–230PubMedGoogle Scholar
  9. Iscove N (1978) Regulation of proliferation and maturation at early and late stages of erythroid differentiation. In: Saunders GF (ed) Cell differentiation and neoplasia. New York, Raven, pp 195–209Google Scholar
  10. Kaszubowksi PA, Goodwin JS, Williams RC (1980) Ia antigen on the surface of a subfraction of T cells that bear Fc receptors for IgG. J Immunol 124:1075–1078Google Scholar
  11. Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–497PubMedCrossRefGoogle Scholar
  12. McMichael AJ, Pilch JR, Galfre G, Mason DY, Fabre JW, Milstein C (1979) A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur J Immunol 9:205–210PubMedCrossRefGoogle Scholar
  13. Moore MAS, Broxmeyer HE, Sheridan APC, Meyers PA, Jacobsen N, Winchester RJ (1980) Continuous human bone marrow culture: Ia antigen characterization of probable pluripotential stem cells. Blood 55:682–690PubMedGoogle Scholar
  14. Pike BL, Robinson J (1970) Human bone marrow colony growth in agar gel. J Cell Physiol 76:77–84PubMedCrossRefGoogle Scholar
  15. Reinherz EL, Schlossman SF (1980) The differentiation and function of human T lymphocytes. Cell 19:821–827PubMedCrossRefGoogle Scholar
  16. Reinherz EL, Nadler LM, Sallan SE, Schlossman SE (1979) Subset derivation of T cell acute lymphoblastic leukaemia in man. J Clin Invest 64:392–397PubMedCrossRefGoogle Scholar
  17. Reinherz EL, Moretta L, Roper M, Breard JM, Mingari MC, Cooper MD, Schlossman SF (1980) Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies: A comparison. J Exp Med 151:969–974PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • P. C. L. Beverley
  • D. Linch
  • R. E. Callard

There are no affiliations available

Personalised recommendations