Abstract
The clinical term “preleukemia” is understood as an alteration of the bone marrow and peripheral blood preceding overt acute myeloid leukemia (AML, review by Saarni and Linman 1973). However, in the majority of cases the diagnosis is only a retrospective one, derived from many mostly clinical and cytogenetic investigations (Fisher et al 1973: Dreyfus 1976; Linman and Bagby 1978; Pierre 1978). The aim of our study was to determine whether there are characteristic lesions of the bone marrow preceding obvious leukemia and if wether those lesions are similar in cases evolving AML or CML later on.
Supported by the Deutsche Forschungsgemeinschaft (DFG Ge 121/19)
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dreyfus B (1976) Preleukemic states. I. Definition and classification. II. Refractory anemia with a excess of myeloblasts in the bone marrow (smoldering acute leukemia). Blood Cells 2:33–55
Fisher WB, Armentrout SA, Weisman R, Graham RC (1973) “Preleukemia” A myelodysplastic syndrome often terminating in acute leukemia. Arch Intern Med 132:226–232
Georgii A (1979) Histopathology of bone marrow in human chronic leukemias. In: Neth, R (eds) Modern trends in human leukemias III. Berlin Heidelberg New York, Springer, pp 60–70
Golde DW, Cline MJ (1973) Human preleukemia. Identification of a maturation defect in vitro. N Engl J Med 28821:1083–1086
Hast R, Reizenstein P (1977) Studies on human preleukaemia. I. Erythroblast and iron kinetics in aregenerative anaemia with hypercellular bone marrow. Scand J Haematol 19:347–354
Koeffler HP, Golde DW (1978) Cellular maturation in human preleukemia. Blood 52:355–361
Linman JW, Bagby GC(1978) Preleukemic syndrome (hemopoietic dysplasia). Cancer 42:854–864
Maldonado JE, Maigne J, Lecoq D (1976) Comparative electronmicroscopic study of the erythrocytic line in refractory anemia (preuleukemia) and myelomonocytic leukemia. Blood Cells 2:167–185
Pierre RV (1978) Preleukemic syndromes Virchows Arch [Cell Pathol] 29:29–37
Saarni, MI, Linman, JW (1973) Preleukemia. The hematologic syndrome preceding acute leukemia. Am J Med 55:38–48
Senn JS, Price GB, Mak TW, McCulloch EA (1976) An approach to human preleukemia using cell culture studies. Blood Cells 2:161–166
Thiele J, Vykoupil KF, Georgii A (1979) Präleukämien: Knochenmarks-und Chromosomenbefunde zum Versuch einer Definition. Verh. Dtsch Ges Path f 63:372–379
Thiele J, Vykoupil KF, Georgii A (1980a) Myeloid dysplasia (MD): A hematological disorder preceding acute and chronic myeloid leukemia. A morphological study on sequential core biopsies of the bone marrow in 27 patients. Virchows Arch, A, [Pathol Anat] 389:343–367
Thiele J, Vykoupil KF, Perschke B, Babilas J, Török M, Krmpotic E, Bodenstein H, Georgii A (to be published b) Preleukaemic lesions of the bone marrow or myeloid dysplasia (MD): Morphological and clinical features in a combined retro- and prospective study of 93 patients.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Georgii, A., Thiele, J., Vykoupil, KF. (1981). Myeloid Dysplasia: the Histopathology of Preleukemia. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K., Winkler, K. (eds) Modern Trends in Human Leukemia IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67984-1_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-67984-1_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10622-7
Online ISBN: 978-3-642-67984-1
eBook Packages: Springer Book Archive