Abstract
The polymorphism of enzyme systems can be ascribed to four different mechanisms. Physicochemical heterogeneity ensues from free combination of subunits constituting the quaternary structure of enzyme proteins. The so-called microheterogeneity is caused by the presence of nonpeptide groups in the enzyme molecules. Furthermore, genetic activity leads to the appearance of molecular enzyme variants called isoenzymes. Finally, the phenotypical expression of genetic variations is usually obscured by the inductive and repressive influences exerted during ontogenesis and differentiation. This is referred to as balanced polymorphism (Ford 1940).
This work was supported by the Deutsche Forschungsgemeinschaft, programs CL3 and CN2
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Daems WT, Poelman RE, Brederoo P (1973) Peroxidatic activity in resident peritoneal macrophages and exudate monocytes of the guinea pig after ingestion of latex particles. J. Histochem Cytochem 21:93–95
Ford EB (1940) In: Huxley J (ed) The new systematics. Clarendon, Oxford, pp 493–513
Lennert K, Stein H, Mohri N, Kaiserling E, Mueller-Hermelink KH (1978) Malignant lymphomas other than Hodgkin’s disease. Springer, New York Berlin Heidelberg
Li CY, Yam LT, Lam KW (1970) Studies of acid Phosphatase isoenzymes in human leucocytes. Demonstration of isoenzyme cell specificity. J Histochem Cytochem 18:901–910
Radzun HJ, Parwaresch MR, Kulenkampff C Staudinger M, Stein H (1980) Lysosomal acid esterase: Activity and isoenzymes in separated normal human blood cells. Blood 55:891–897
Radzun HJ, Parwaresch MR, Kulenkampff C, Stein H (1980) Lysosomal acid Phosphatase: Activity and isoenzymes in separated normal human blood cells. Clin Chim Acta 102:227–235
Schmidt D, Radzun HJ, Schwarze E, Stein H, Parwaresch MR (1980) Activity and isoenzymes of acid Phosphatase in human B-cell lymphoma of low grade malignancy. A novel aid in the classification of malignant lymphoma. Cancer 46:2676–2681
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© 1981 Springer-Verlag Berlin Heidelberg
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Radzun, H.J., Parwaresch, M.R., Lennert, K. (1981). Enzyme Polymorphism as a Biochemical Cell Marker: Application to the Cellular Origin and Homogeneity of Human Macrophages and to the Classification of Malignant Lymphomas. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K., Winkler, K. (eds) Modern Trends in Human Leukemia IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67984-1_36
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DOI: https://doi.org/10.1007/978-3-642-67984-1_36
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