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Immunsuppression

  • Chapter
Transplantationschirurgie

Part of the book series: Allgemeine und spezielle Operationslehre ((OPERATIONSLEHRE,volume 3))

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Zusammenfassung

Der Erfolg einer allogenen Organtransplantation ist abhängig von der Kontrolle der immunologischen Abstoßungsreaktion durch eine immunsuppressive Behandlung des Empfangerorganismus. Eine unspezifische Immunsuppression wird durch eine Reihe sehr unterschiedlicher Maßnahmen wie Behandlung mit ionisierenden Strahlen, Depletion lymphatischer Zellen mittels Ductus thoracicus Drainage, Thymektomie und Splenektomie und vor allem durch medikamentöse Behandlung mit verschiedenen Substanzen erzielt. Tabelle 1 zeigt eine Übersicht über die zahlreichen Stoffe, für die eine immunsuppressive Wirkung nachgewiesen werden konnte. Die wichtigsten Gruppen sind alkylierende Substanzen, Antimetabolite, Corticosteroide und Antilymphocytenseren.

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Authors
  1. G. P. J. Alexandre
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  2. K. Wonigeit
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  3. H. Bunzendahl
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Editor information

Editors and Affiliations

  1. Kinderpoliklinik, Universität München, Landwehrstraße 61, 8000, München 2, Deutschland

    E. Albert

  2. Departement Chirurgie, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, B-1200, Bruxelles, Belgien

    G. P. J. Alexandre

  3. Chirurgische Klinik und Poliklinik, Universität Tübingen, Calwer Straße 7, 7400, Tübingen 1, Deutschland

    H. Bockhorn

  4. Institutes für chirurgische Forschung, Klinikum Großhadern, Universität München, Marchioninistraße 15, 8000, München 70, Deutschland

    W. Brendel (Direktor) & C. Hammer (Direktor) & 

  5. Klinik für Abdominal- und Transplantationschirurgie, Medizinischen Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Deutschland

    Ch. Brölsch , E. Guthy , W. Lauchart , D. Löhlein , P. Neuhaus , R. Pichlmayr (Leiter), E. Wagner  & K. Wonigeit , , , , ,  (Leiter),  & 

  6. Chirurgischen Universitätsklinik im Klinikum Westend, Freien Universität Berlin, Spandauer Damm 130, 1000, Berlin 19, Deutschland

    E. S. Bücherl (Direktor) (Direktor)

  7. Abdominal- und Transplantationschirurgie, Medizinischen Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Deutschland

    H. Bunzendahl

  8. Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA

    J. E. Burke M.D. (Professor of Surgery) (Professor of Surgery)

  9. Department of Surgery, University of Cambridge, Addenbrooks Hospital, Cambridge, England

    R. Y. Calne

  10. Urologische Klinik, Universität München, Klinikum Großhadern, Marchioninistraße 15, 8000, München 70, Deutschland

    Ch. Chaussy

  11. Abteilung für Allgemeinchirurgie im Lukaskrankenhaus Neuss, Preußenstraße 84, 4040, Neuss, Deutschland

    A. J. Coburg (Chefarzt) (Chefarzt)

  12. Abteilung für Kardiochirurgie, Universitätskliniken Köln, Joseph-Stelzmann-Straße 9, 5000, Köln 41, Deutschland

    H. Dalichau (Direktor) (Direktor)

  13. Abteilung Psychosomatik im Zentrum Psychologische Medizin, Medizinischen Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Deutschland

    H. Freyberger (Leiter) (Leiter)

  14. Klinik für Gefäßkrankheiten, Aggertalklinik, 5250, Engelskirchen-Grünscheid, Deutschland

    R. Giessler

  15. Chirurgische Universitätsklinik und Poliklinik, Joseph-Stelzmann-Straße 9, 5000, Köln 41, Deutschland

    R. Grundmann  & H. Pichlmaier (Direktor) &  (Direktor)

  16. Abteilung für Unfallchirurgie, Chirurgische Universitätsklinik Freiburg, Hugstetter Straße 55, 7800, Freiburg, Deutschland

    W. Hesse

  17. Institut für Hämatologie, Gesellschaft für Strahlen- und Umweltforschung, Abteilung Immunologie, Landwehrstraße 61, 8000, München 2, Deutschland

    H. J. Kolb

  18. Arbeitsbereiches Immunpathologie, Institut für Pathologie, Freien Universität Berlin, Klinikum Charlottenburg, Spandauer Damm 130, 1000, Berlin 19, Deutschland

    P. H. Krause (Leiter) (Leiter)

  19. Chirurgische Klinik A, Universitätsspital Zürich, Rämistraße 100, CH-8091, Zürich, Schweiz

    F. Largiadèr

  20. Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Medizinischen Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Deutschland

    E. Lehnhardt (Leiter) & H.-J. Schultz-Coulon (Leiter) & 

  21. Klinik für Herz- und Gefäßchirurgie, Deutsches Herzzentrum München, Lothstraße 11, 8000, München 2, Deutschland

    H. Meisner (Leitender Arzt) (Leitender Arzt)

  22. Augenabteilung, Marienhospital Osnabrück, Johannisfreiheit 2-4, 4500, Osnabrück, Deutschland

    H. J. Meyer (Chefarzt) (Chefarzt)

  23. I. Chirurgische Universitätsklinik, Allgemeines Krankenhaus der Stadt Wien, Alser Straße 4, A-1090, Wien IX, Österreich

    H. Millesi

  24. Anästhesiologie-Abteilung im Krankenhaus Oststadt, Medizinischen Hochschule Hannover, Podbielskistraße 380, 3000, Hannover 51, Deutschland

    I. Pichlmayr (Leiterin) (Leiterin)

  25. Unfallchirurgische Klinik, Medizinischen Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Deutschland

    H. Reilmann

  26. Klinik für Herz- und Gefäßchirurgie, Deutschen Herzzentrum München, Lothstraße 11, 8000, München 2, Deutschland

    P. Schmidt-Habelmann , F. Sebening (Direktor) & E. Struck ,  (Direktor) & 

  27. Institutes für Hämatologie, Gesellschaft für Strahlen- und Umweltforschung, Abteilung Immunologie, Landwehrstraße 61, 8000, München 2, Deutschland

    S. Thierfelder (Direktor) (Direktor)

  28. Klinik für Allgemeinchirurgie im Krankenhaus Nordstadt, Haltenhoffstraße 47, 3000, Hannover 1, Deutschland

    G. Tidow (Chefarzt) (Chefarzt)

  29. Unfall- und Wiederherstellungschirurgie im Krankenhaus Nordstadt, Haltenhoffstraße 47, 3000, Hannover 1, Deutschland

    O. Trentz (Chefarzt) (Chefarzt)

  30. Unfallchirurgischen Klinik, Medizinischen Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Deutschland

    H. Tscherne (Leiter) (Leiter)

  31. Chirurgische Klinik Dr. Rinecker, Isartalstraße 82, 8000, München 70, Deutschland

    R. Zenker

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Alexandre, G.P.J., Wonigeit, K., Bunzendahl, H. (1981). Immunsuppression. In: Albert, E., et al. Transplantationschirurgie. Allgemeine und spezielle Operationslehre, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67966-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-67966-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67967-4

  • Online ISBN: 978-3-642-67966-7

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