Transplantation von Knochenmark

  • H. J. Kolb
  • S. Thierfelder
Part of the Allgemeine und spezielle Operationslehre book series (OPERATIONSLEHRE, volume 3)

Zusammenfassung

Das Ziel der Knochenmarktransplantation (KMT) ist der Ersatz blutbildenden Gewebes bei Individuen mit gestörter Blutbildung, maligne entarteter Blutbildung und gestörtem Immunsystem. Ferner kann die KMT eine wirkungsvolle hochdosierte zytostatische Behandlung anderer maligner Erkrankungen ermöglichen, die ansonsten durch die Knochenmarktoxizität der Behandlung begrenzt ist. Grundsätzlich besteht die Möglichkeit, die Reaktion immunkompetenter Zellen des Transplantates gegen den Empfänger — Graft-versus-Host-Reaktion (GvHR) — zur Ausschaltung restlicher leukämischer Zellen auszunützen. Die erfolgreiche Transplantation hämopoetischen Gewebes erlaubt in der Regel die Transplantation anderer Organe desselben Spenders ohne erneute immunsup-pressive Behandlung.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1981

Authors and Affiliations

  • H. J. Kolb
  • S. Thierfelder

There are no affiliations available

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