Skip to main content
SpringerLink
Log in

Konservative Therapie

  • Chapter
Dickdarm

Part of the book series: Handbuch der inneren Medizin ((INNEREN 3,volume 3 / 4))

  • 36 Accesses

Zusammenfassung

Der Krankheitsverlauf der Colitis ulcerosa und der Colitis granulomatosa hat sich seit der Einführung von Glukokortikosteroiden, von Salizylazosulfapyridin und einer Reihe weiterer therapeutischer Maßnahmen, die keinen spezifischen Effekt auf die entzündlichen Dickdarmerkrankungen haben, entscheidend gebessert. Der oft hohe objektive und subjektive Schweregrad der Kolitiden mit erheblicher Letalitätsquote und die Unvorhersehbarkeit des Rezidivs zwin-gen dazu, alle Kranken medikamentos zu behandeln, so daß es keine unbehandel-ten Fälle mehr gibt. Die Mortalität ist seit der Einführung der Glukokortikosteroide gesunken (EDWARDS u. TRUELOVE 1963). Ferner besteht der Eindruck, daß die Häufigkeit der ausgedehnten Dickdarmentzündungen abnimmt und die mehr distalen lokalisierten Formen der Colitis ulcerosa zunehmen. Ob es sich hierbei um eine Therapiewirkung handelt, nämlich eine Hemmung der Progredienz, konnte bisher nicht geklärt werden. Der spontane Verlauf der unbehandelten entzündlichen Dickdarmerkrankung kann seit dem Beginn des 7. Jahrzehnts durch die stets angewendete medikamentöse Therapie nicht mehr beobachtet werden. Im allgemeinen wird angenommen, daß bei Erstmanifestation der Colitis ulcerosa im Erwachsenenalter durch die Behandlungsmaßnahmen eine gewisse Stabilisierung, Abnahme der Progressivität, Verkürzung der aktiven Erkrankungsphasen (Schub), Senkung der Sterblichkeitsquote, Verringerung der Krankenhausbedürftigkeit und Verlängerung der Remission erreicht werden konnte. Es gibt jedoch nach wie vor keine therapeutische Möglichkeit, eine medikamentöse Heilung zu erreichen. Dies ist unverändert nur durch eine totale Proktokolektomie bei der Colitis ulcerosa möglich

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aber GM, Ashton F, Carmalt MHB, Whitehead TP (1967) Gastric hypersecretion following massive small bowel resection in man. Am J Dig Dis 12:785–794

    PubMed  CAS  Google Scholar 

  • Alarcon-Segovia D, Herskovic T, Dearing WH, Bartholomew LG, Cain JC, Shorter RG (1965) Lupus erythematosus cell phenomenon in patients with ulcerative colitis. Gut 6:39

    PubMed  CAS  Google Scholar 

  • Alexanderson B, Evans DAP, Sjöquist F (1969) Steady-state plasma levels of Nortriptyline in twins. Influence of geratic factors and drug therapy. Br Med J 1:764

    Google Scholar 

  • Allen R, Cooke WT (1975) Evaluation of metronidazole in the management of Crohn’s disease. Gut 18: A 422

    Google Scholar 

  • Almy TP (1961) Ulcerative colitis. Gastroenterology 41:391

    PubMed  CAS  Google Scholar 

  • Almy TP, Lewis CM (1963) Ulcerative colitis. A report of progress based upon the recent literature. Gastroenterology 45:515

    PubMed  CAS  Google Scholar 

  • Altman GG (1971) Influence of bile and pancreatic secretions on the size of the intestinal villi in the rat. Am J Anat 132:167–178

    Google Scholar 

  • Ammann RW, Müller-Schoop J, Knoblauch M (1978) Therapie des Morbus Crohn im akuten Schub mit Ornidazol (Tiberal). Schweiz Med Wochenschr 108:1075

    PubMed  CAS  Google Scholar 

  • Ammon HV, Phillips SF (1973) Inhibition of colonic water and electrolyte absorption by fatty acids in man. Gastroenterology 65:744–749

    PubMed  CAS  Google Scholar 

  • Anderson DL, Boyce HW (1973) Use of parenteral nutrition in treatment of advanced regional enteritis. Am J Dig Dis 18:633–640

    PubMed  CAS  Google Scholar 

  • Andersson H (1976) Effects of a fat-reduced diet on the faecal excretion of radioactivity following administration of C 14-cholic acid and on the duodenal concentration of bile salts in patientswith ileal disease. Nutr Metab 20:254

    PubMed  CAS  Google Scholar 

  • Andersson H, Jagenburg R (1974) Fat-reduced diet in treatment of hyperoxaluria in patients with ileopathy. Gut 15:360

    PubMed  CAS  Google Scholar 

  • Andersson H, Isaksson B, Sjörgen B (1974) Fat-reduced diet in the symptomatic treatment of small bowel disease. Metabolic studies in patients with Crohn’s disease and in other patients subjected to ileal resection. Gut 15:351–359

    PubMed  CAS  Google Scholar 

  • Anthonisen P, Barany F, Folkenborg P, Holtz A, Jarnum S, Kristensen M, Riis F, Alan W, Worning H (1974) The clinical effect of salazosulphapyridine (Salazopyrin) in Crohn’s disease. A controlled double-blind study. Scand J Enterol 9:549–554

    CAS  Google Scholar 

  • Asquith P, Mallas E, Ross I, Montgomery RD, Cooke WT, Thompson RA (1975) Transferfactors in the treatment of Crohn’s disease. Gut 16:832

    PubMed  CAS  Google Scholar 

  • Axelsson Ch, Jarnum S (1977) Assessment of therapeutic value of elemental diet in chronic inflammatory bowel disease. Scand J Gastroenterol 12:89–95

    PubMed  CAS  Google Scholar 

  • Azad Khan AK, Truelove SC (1979) Placental and mammary transfer of sulphasalazine. Br Med J II:1553

    Google Scholar 

  • Azad Khan AK, Johston HH, Truelove SC (1975) Bacterial breakdown of sulphasalazine (Salazopyrin). Gut 16:832

    PubMed  CAS  Google Scholar 

  • Azad Khan AK, Piris J, Truelove SC (1977 a) An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet II: 892–895

    PubMed  CAS  Google Scholar 

  • Azad Khan AK, Howes DT, Piris J, Truelove SC (1977 b) Optimal dose of sulphasalazine for maintenance treatment of ulcerative colitis: interim results of a controlled therapeutic trial. Gut 18:421

    Google Scholar 

  • Barany FR (1976) Salazosulphapyridine in the treatment of Crohn’s disease. In: Weterman IT, Pena AS, Booth CC (eds) The management of Crohn’s disease. Excerpta Medica, Amsterdam Oxford, p 172

    Google Scholar 

  • Bardet IC, Besancon F, Bourdais IP (1978) Le traitement de la maladie de Crohn par le metronidazole. Gastroenterol Clin Biol 2:342–343

    Google Scholar 

  • Baron JH, Connell AM, Kanaghinis TG, Lennard-Jones JE, Avery-Jones F (1962a) Out patient treatment of ulcerative colitis. Comparison between three doses of oral prednisone. Br Med J 1:441

    Google Scholar 

  • Baron JH, Connell AM, Lennard-Jones JE, Jones E, Avery F (1962 b) Sulphasalazine and salicylazosulphapyridine in ulcerative colitis. Lancet I:1094–1096

    PubMed  CAS  Google Scholar 

  • Barrett A, Fitzharris BM, Robson T, Smyth JF (1978) Lymphoma after S.L.E. Lancet II: 1102

    PubMed  CAS  Google Scholar 

  • Bayless TM, Whitington PF, Barnes H (1977) Crohn’s disease in adolescents: long term alternate day prednisone therapy. Gastroenterology 72:1028

    Google Scholar 

  • Bean RHD (1962) The treatment of chronic ulcerative colitis with 6-mercaptopurine. Med J Aust 2:592–593

    Google Scholar 

  • Bean RHD (1966) Treatment of ulcerative colitis with antimetabolites. Br Med J I:1081–1084

    PubMed  CAS  Google Scholar 

  • Becker HD, Reeder DD, Thompson JC (1973) Extraction of circulating endogenous gastrin by the small bowel. Gastroenterology 65:903–906

    PubMed  CAS  Google Scholar 

  • Bercovitz ZT (1950) Chloromycetin therapy of ulcerative colitis — a one year study. Gastroenterology 16:19

    PubMed  CAS  Google Scholar 

  • Bercovitz ZT, Sommers SC (1966) Altered inflammatory reaction in nonspecific ulcerative colitis. Arch Intern Med 117:504–510

    PubMed  CAS  Google Scholar 

  • Berg G, Classen M (1973) Erfahrungen mit einer bilanzierten ballastfreien Ernahrung beim MorbusCrohn und Colitis ulcerosa. Med Klin 68:487

    PubMed  CAS  Google Scholar 

  • Berg G, Wagner H, Weber L (1972) Bilanzierte ballastfreie Ernährung bei Darmerkrankungen. Dtsch Med Wochenschr 97:826

    PubMed  CAS  Google Scholar 

  • Bergman L, Krause U (1976) Postoperative treatment with corticosteroids and salazosulphapyridin (Salazopyrin) after radical resection for Crohn’s disease. Scand J Gastroenterol 11:651–656

    PubMed  CAS  Google Scholar 

  • Berlin CM, Yaffe SJ (1979) Disposition of sulfasalazine (Azulfidine) in human breast milk, plasma and saliva. Pediatr Res 13:396

    Google Scholar 

  • Best WR, Becktel JM, Singleton JW, Kern F (1976) Development of a Crohn’s disease activity index: National Cooperative Crohn’s Disease Study. Gastroenterology 70:439–444

    PubMed  CAS  Google Scholar 

  • Binder HJ, Gryboski JD, Thayer WR, Spiro HM (1966) Intolerance to milk in ulcerative colitis: A preliminary report. Am J Dig Dis 11:858

    PubMed  CAS  Google Scholar 

  • Birkner HJ, Kern FK (1974) In vitro adsorption of bile salts to food residues, salicylazosulphapyridine, and hemicellulose. Gastroenterology 67:237

    PubMed  CAS  Google Scholar 

  • Blackstone MO (1978) Hypersensitivity reaction to sulfasalazine — two reports of the same patient. Gastroenterology 75:1192–1193

    PubMed  CAS  Google Scholar 

  • Blichfeldt P, Blomhoff JP, Myhre E, Gjone E (1976) Metronidazole in Crohn’s disease — a preliminaryreport of a doubleblind cross-over study. Scand J Gastroenterol ll:Suppl. 38, 100

    Google Scholar 

  • Blichfeldt P, Blomhoff JP, Myhre E, Gjone E (1978) Metronidazole in Crohn’s disease. A double-blind cross-over clinical trial. Scand J Gastroenterol 13:123–127

    PubMed  CAS  Google Scholar 

  • Block MB, Genant HK, Kirsner JB (1970) Pancreatitis as an adverse reaction to salicylazosulfapyridine. N Engl J Med 282:380

    PubMed  CAS  Google Scholar 

  • Blum AL, Peters P, Kreys GJ (1975) Dünndarmresektion. Internist 16:260

    PubMed  CAS  Google Scholar 

  • Bochenek W, Rodgers JB, Balint J A (1970) Effect of changes in dietary lipids on intestinal fluid loss in the short bowel syndrom. Ann Intern Med 72:205–230

    PubMed  CAS  Google Scholar 

  • Böttiger LE, Möllenberg H (1959) Metabolic studies on azulfidine, azudimidine and one analogue. Acta Med Scand 165:241–244

    PubMed  Google Scholar 

  • Böttiger LE, Engstedt L, Lagerantz R, Nyberg N (1963) The occurence of Heinz bodies during Azulfidine treatment of ulcerative colitis. Gastroenterologia (Basel) 100:33

    Google Scholar 

  • Bond JH, Levitt MD (1976) Fate of soluble carbohydrate in the colon of rats and man. J Clin Invest 57:1158–1164

    PubMed  CAS  Google Scholar 

  • Booth CC, Maclntyre I, Mollini DL (1964) Nutritional problems associated with extensive lesions of the distal intestine in man. Q J Med 131:401–420

    Google Scholar 

  • Bowen GE, Irons GV, Rhodes JB, Kirsner JB (1966) Early experience with azathioprine in ulcerative colitis. A note of caution. J Am Med Assoc 195:460–464

    CAS  Google Scholar 

  • Broders AC, Bargen J A (1960) Salicylazo-sulfadimethylpyrmidine (Azudimidine) in the treatment of ulcerative colitis. Writings and reports, Scott and White Clinic 3:229

    Google Scholar 

  • Brooke BN, Javett SL, Davison OW (1970) Further experience with azathioprine for Crohn’s disease. Lancet 11:1050–1053

    Google Scholar 

  • Brooke BN, Cave DR, King DW (1976) Place of azathioprine for Crohn’s disease. Lancet 1:1041–1042

    PubMed  CAS  Google Scholar 

  • Brown CH, Merlo M (1961) Topical steroid therapy for ulcerative colitis. Am J Gastroenterol 36:343

    Google Scholar 

  • Buckell NA, Gould SR, Day DW, Lennard-Jones JE, Edwards AM (1978) Controlled trial of disodium cromoglycate in chronic persistent ulcerative colitis. Gut 19:1140–1143

    PubMed  CAS  Google Scholar 

  • Buisseret PP, Youlten LJF, Heinzelmann DI, Lessof MH (1978) Prostaglandin-synthesis-inhibitors in prophylaxis of food intolerance. Lancet 1:906–908

    PubMed  CAS  Google Scholar 

  • Burkitt DP (1969) Related disease — related cause? Lancet II: 1229

    PubMed  CAS  Google Scholar 

  • Burkitt DP (1970) Relationship as a clue to causation. Lancet II: 1237

    PubMed  CAS  Google Scholar 

  • Burnet FM (1967) Concepts of autoimmune disease and their implications for therapy. Perspect Biol Med 10:141–151

    PubMed  CAS  Google Scholar 

  • Burnham WR, Lennard-Jones JE, Colin R, Geffroy Y (1979) Oral BCG vaccine in Crohn’s disease. Gut 20:229

    PubMed  CAS  Google Scholar 

  • Bury KD (1976) Elemental diets. In: Fisher JE (ed) Total parenteral nutrition. Little, Brow, Boston, p 395

    Google Scholar 

  • Busk HE, Dahlerup B, Lytzen T, Binder V, Gudmand-Hoyer E (1975) The incidence of lactose malabsorption in ulcerative colitis. Scand J Gastroenterol 10:263–265

    PubMed  CAS  Google Scholar 

  • C&bellAC, Skinner JM, Hersey P, Robets-Thomson P, MacLennan ICM, Truelove SC (1974) Immunosuppression in the treatment of inflammatory bowel disease. I. Changes in lymphoid subpopulations in the blood and rectal mucosa following cassation of treatment with azathioprine. Clin Exp Immunol 16:521–523

    Google Scholar 

  • C&bellAC, Skinner JM, MacLennan IC, Bersey P, Waller CA, Wood J, Jewell DP, Truelove SC (1976) Immunosuppression in the treatment of inflammatory bowel disease. II. The effect of azathioprine on lymphoid cell populations in a double blind trial in ulcerative colitis. Clin Exp Immunol 24:249–258

    Google Scholar 

  • C&bellDES (1973) Nya rön om Salazopyrins farmakokinetik och farmakologi. Läkartidaingen 70:3068

    Google Scholar 

  • C&ieri M, Lanfranchi GA, Bazzocchi G, Brignola C, Corazza G, Lortini C, Michelini M, Labo G (1978) Salicylate after than 5-amino-salicylic acid ineffective in ulcerative colitis. Lancet II:993

    Google Scholar 

  • Caravatti CM, Hooker TN (1971) Acute massive hepatic necrosis with fatal liver failure. Am J Dig Dis 16:803–808

    Google Scholar 

  • Caridis DT, Roberts M, Smith G (1969) The effect of small bowel resection on gastric acid secretion in the rat. Surgery 65:292–297

    PubMed  CAS  Google Scholar 

  • Caspary WF (1975) Erworbene Hyperoxalurie und Nephrolithiasis bei gastroenterologischen Erkrankungen („enterale“ Hyperoxalurie). Dtsch Med Wochenschr 100:1509

    PubMed  CAS  Google Scholar 

  • Cesnik H (1968) Thymektomie bei Colitis ulcerosa. Vorläufiger Bericht über einen Behandlungsversuch bei 7 Patienten. Langenbecks Arch Klin Chir 321:86–98

    CAS  Google Scholar 

  • Cesnik H, Schmid KO (1971) Über Lymphfollikel im Thymus bei Colitis ulcerosa. Langenbecks Arch Klin Chir 328:128–138

    CAS  Google Scholar 

  • Chaput JC, Buffet C, Papoz L, Etienne JP (1978) Chronic active hepatitis and extrahepatic malignancy. Lancet I:1367

    PubMed  CAS  Google Scholar 

  • Clarke JR, Richens ER, Williams MJ, Gough KR, Ancill RJ (1974) An evaluation of the rosetteinhibition test in Crohn’s disease. Gut 15:725–727

    PubMed  CAS  Google Scholar 

  • Cleave TC (1974) The saccharine disease. Wright, Bristol

    Google Scholar 

  • Clements R, Hale CG, Jones RF, Pearson CC (1962) Topical steroid therapy in ulcerative colitis. Am J Dig Dis 7:760

    PubMed  CAS  Google Scholar 

  • Clifton J A (1979) Konservative Behandlung der Crohn’schen Erkrankung. Internist (Berlin) 20:167–170

    CAS  Google Scholar 

  • Cline MJ, Melmon KL (1966) Plasma kinins and Cortisol: a possible explanation of the antiinflammatory action of Cortisol. Science 153:1135–1138

    PubMed  CAS  Google Scholar 

  • Collier HOJ, Francis AA, McDonald-Gibson WJ, Saeed SA (1976) Inhibiton of prostaglandin biosynthesis by sulphasalazine and its metabolites. Prostaglandins 11:219–225

    PubMed  CAS  Google Scholar 

  • Compston JE, Creamer B (1977) The consequences of small intestinal resection. Q J Med 46:485–497

    PubMed  CAS  Google Scholar 

  • Connell AM, Lennard-Jones JR, Misiewicz JJ, Baron JH, Avery JF (1965a) Comparison of aceteroland prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis. Lancet 1:238–239

    PubMed  CAS  Google Scholar 

  • Connell AM, Jones FA, Rowlands EN (1965 b) Motility of the pelvic colon. Gut 6:105

    PubMed  CAS  Google Scholar 

  • Connor WE (1975) Pathogenesis and frequency of essential fatty acid deficiency during total parenteral nutrition. Ann Intern Med 83:895–896

    PubMed  CAS  Google Scholar 

  • Cooke EM (1969) Fecal flora of patients with ulcerative colitis during treatment with salicylazosulphapyridin. Gut 10:565

    PubMed  CAS  Google Scholar 

  • Cooke EM, Ewins SP, Hywel-Jones J, Lennard-Jones JE (1974) Properties of strains of Escherichia coli carried in different phases of ulcerative colitis. Gut 15:143–146

    PubMed  CAS  Google Scholar 

  • Cooke WT, Fielding JF (1970) Corticosteroid or corticotrophin therapy in Crohn’s disease (Regional Enteritis). Gut 11:921–927

    PubMed  CAS  Google Scholar 

  • Cowan GO, Das KM, Eastwood MA (1977) Further studies of sulfasalazine metabolism and the treatment of ulcerative colitis. Br Med J II:1057–1059

    PubMed  CAS  Google Scholar 

  • Crean GP, Loraine J A, Bell ET, Card WI, Sircus W (1966) Urinary gonadotropin excretion in patients with ulcerative colitis, and Crohn’s disease treated with ACTH and corticosteroids. Gut 7:597

    PubMed  CAS  Google Scholar 

  • Cummings JH, James WTP, Wiggins HS (1973) Role of the colon in ileal-resection diarrhoea. Lancet I:344–347

    PubMed  CAS  Google Scholar 

  • Czaja A J, Summerskill WHJ (1977) Malignancy in chronic liver disease. Gastroenterology 73:192

    PubMed  CAS  Google Scholar 

  • Daneman HA, Texter EC, Chejfic G, Barborka CJ (1961) The effect of treatment upon the clinical course of ulcerative colitis. — Observations on the value of adjunctive therapy, azulfidine, A.C.T.H., and adrenal steroids, psychotherapy, and surgery. Proc. Int. Congr. Gastroenterology, Ley den 1960, Excerpta Medica, Amsterdam London New York

    Google Scholar 

  • Dargent M, Bourgoin J-J, Noel P, Weissbrod R (1972) The influence of azathioprine on tumorogenesis by 7–12 dimethylbenz anthracene in rats. Eur J Cancer 8:605–609

    PubMed  CAS  Google Scholar 

  • Das KM (1976) Sulphasalazine metabolism in patients with Crohn’s disease. In: Weterman IT, Pena AS, Booth CC (eds) The management of Crohn’s disease. Excerpta Medica, Amsterdam Oxford, pp 161–171

    Google Scholar 

  • Das KM (1978) Sulfasalazine revisited. Gastroenterology 75:1181–1182

    Google Scholar 

  • Das KM, Eastwood MA (1973) Effect of iron and calcium on salizylazosulfapyridin metabolism. Scott Med J 18:45–50

    PubMed  CAS  Google Scholar 

  • Das KM, Eastwood MA (1975) Acetylation polymorphism of sulfa pyridine in paients with ulcerative colitis and Crohn’s disease. Clin Pharmacol Ther 18:514–520

    PubMed  CAS  Google Scholar 

  • Das KM, Sternlieb I (1975) Sulfasalazine in inflammatory bowel disease. Am J Dig Dis 29:975

    Google Scholar 

  • Das KM, Eastwood MA, McManus JPA, Sircus W (1973) The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in patients. — II. The relationship between metabolites and the progress of the disease studied in outpatients. Gut 14:631–641

    PubMed  CAS  Google Scholar 

  • Das KM, Eastwood MA, MacManus JPA, Sircus W (1974) The role of the colon, in the metabolism of salizylazosulfapyridine. Scand J Gastroenterol 9:137–141

    PubMed  CAS  Google Scholar 

  • Das KM, Chowdhury JR, Zapp B, Fara JW (1979) Small bowel absorption of sulfasalazine and its hepatic metabolism in human beings, cats and rats. Gastroenterology 77:280

    PubMed  CAS  Google Scholar 

  • Davies PS, Rhodes J (1978) Maintenance of remission in ulcerative colitis with sulfasalazine or a high-fiber diet. A clinical trial. Br Med J 1:1524–1525

    PubMed  CAS  Google Scholar 

  • Davies PS, Rhodes I, Heatley RV, Owen E (1977) Metronidazole in the treatment of chronic proctitis. A controlled trial. Gut 18:680–684

    PubMed  CAS  Google Scholar 

  • Debongnie JC, Philips SF (1978) Capacity of the human colon to absorb fluid. Gastroenterology 74:698–703

    PubMed  CAS  Google Scholar 

  • Dick AP, Grayson NJ, Carpenter RG, Petrie A (1964) Controlled trial of sulphasalazine in the treatment of ulcerative colitis. Gut 5:437–444

    PubMed  CAS  Google Scholar 

  • Dickson RJ, Ashton MG, Axon ATR, Golligher JC, Smith RC, Yeung CK, Hill GL (1980) Gut 21:411

    Google Scholar 

  • Dissanayake AS, Truelove SC (1973) A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphasalazine (Salazopyrin). Gut 14:923–926

    PubMed  CAS  Google Scholar 

  • Dobbins JW, Binder HJ (1977) Derangements of oxalate metabolisms in gastrointestinal disease and their mechanisms. In: Glass GBJ (ed) Progress in gastroenterology, vol III. Grune&Stratton, New York London San Francisco

    Google Scholar 

  • Domenjoz R (1960) The pharmacology of phenylbutazone analogues. Ann NY Acad Sci 86:263

    CAS  Google Scholar 

  • Domenjoz R (1961) Anti-inflammatory effect of Salazopyrin. Internal Pharmacia Report Pharmacia AB, Uppsala

    Google Scholar 

  • Dowling RN (1974) The influence of luminal nutrition on intestinal adaption after small bowel resection and by-pass. In: Dowling HH, Riecken EO (eds) Intestinal adaption. Schattauer, Stuttgart New York, pp 35–45

    Google Scholar 

  • Dowling RH, Booth CC (1967) Structural and functional changes following small intestinal resection in the rat. Clin Sci 32:139–149

    PubMed  CAS  Google Scholar 

  • Driscoll RH, Rosenburg IH (1978) Total parenteral nutrition in inflammatory bowel disease. Med Clin North Am 62:184–201

    Google Scholar 

  • Dronfield MW, Langman MJS (1977) Controlled comparison of sodium cromoglycate and sulphasalazine in the maintenance of remission in ulcerative colitis. Gut 18:973

    Google Scholar 

  • Dronfield MW, Langman MJS (1978) Comparative trial of sulphasalazine and oral sodium cromoglycate in the maintenance of remission of ulcerative colitis. Gut 19:1136–1139

    PubMed  CAS  Google Scholar 

  • Dronfield MW, Malone JDG, Langman MJS (1977) Zinc in ulcerative colitis: a therapeutical trial and report on plasma levels. Gut 18:33–36

    PubMed  CAS  Google Scholar 

  • Dudrick SJ, Ruber RL (1971) Principals and practice of parenteral nutrition. Gastroenterology 61:901–910

    PubMed  CAS  Google Scholar 

  • Dujovne CH, Chan CH, Zimmermann JH (1967) Sulfonamide hepatic injury. N Engl J Med 277:785–788

    PubMed  CAS  Google Scholar 

  • Dyer HN (1972) Medical management of Crohn’s disease. Clin Gastroenterol 1:449

    Google Scholar 

  • Ebberle P, Hunstein W, Perings E (1968) Chromosomes in patients treated with imuran. Humangene-tik 6:69–73

    Google Scholar 

  • Eckhardt R, Kloos R, Dierich P, Meyer zum Büschenfelde KH (1977) Lymphocytes (killer-cells) in Crohn’s disease and acute virus B-hepatitis. Gut 18:1010–1016

    PubMed  CAS  Google Scholar 

  • Editorial (1969) Immunsuppression and cancer. Lancet II:505

    Google Scholar 

  • Editorial (1972) Immunosuppressives and malignancy. Br Med J III:713

    Google Scholar 

  • Editorial (1974) Total parenteral nutrition and Crohn’s disease. Nutr Rev 32:72

    Google Scholar 

  • Editorial (1975) Gastric emptying, pancreatic and biliary secretion during digestion. Nutr Rev 33:169

    Google Scholar 

  • Editorial (1979) Nutritional management of enterocutaneous fistulas. Lancet II:507

    Google Scholar 

  • Edwards FC, Truelove SC (1963) The course and prognosis of ulcerative colitis. Gut 4:299

    PubMed  CAS  Google Scholar 

  • Elliott PR, Powell-Tuck J, Gillepsie PE, Laidlow JM, Lennard-Jones JE, English J, Chakraborty J, Marks V (1980) Prednisolone absorption in acute colitis. Gut 21:49

    PubMed  CAS  Google Scholar 

  • Engbaek J, Ersböll J, Faurby V, Binder V, Riis P (1975) The constipating effect of diphenoxylate (Retardin (R)) in ulcerative colitis. A double-blind controlled trial. Scand J Gastroenterol 10:695–698

    PubMed  CAS  Google Scholar 

  • Enochs MR, Johnson LR (1977) Hormonal regulation of gastrointestinal tract growth; biochemical and physiological aspects. In: Glass GBJ (ed) Progress in gastroenterology, vol III. Grune & Stratton, New York San Francisco London, pp 3–28

    Google Scholar 

  • Evans DAP, White TA (1964) Human acetylation polymorphism. J Lab Clin Med 63:394

    PubMed  CAS  Google Scholar 

  • Ewart WB, Lennard-Jones JE (1961) Corticosteroids in preoperative medical management of ulcerative colitis. Lancet II:60

    Google Scholar 

  • Fahrländer F (1980) The use of salazopyrin during pregnancy. Xlth Int. Congr. of Gastroenterology, A.S.N.E.M.G.E.

    Google Scholar 

  • Falchuk KR, Isselbacher KJ (1976) Characterization of the antibody response. Gastroenterology 70:5–8

    PubMed  CAS  Google Scholar 

  • Fazio VW, Kopner I, Jagelman DG, Turnbull RB, Weakley FC (1976) Parenteral nutrition as primary or adjunctive treatment. Dis Colon Rectum 19:574–578

    PubMed  CAS  Google Scholar 

  • Feldman EJ, Dowling RH, McNaughton J, Peters TJ (1976) Effects of oral versus intravenous nutrition on intestinal adaption after small bowel resection in the dog. Gastroenterology 70:712–719

    PubMed  CAS  Google Scholar 

  • Fleming CR, McGill DB, Berkner S (1977) Home parenteral nutrition as primary therapy in patients with extensive Crohn’s disease of the small bowel and malnutrition. Gastroenterology 73:1077–1081

    PubMed  CAS  Google Scholar 

  • Fore H, Walker R, Goldberg L (1967) Studies on F.K. Brown II. Degradative charges undergone in vitro and in vivo. Food Cosmet Toxicol 5:459

    PubMed  CAS  Google Scholar 

  • Foreman JC, Garland LG (1976) Cromoglycate and other anti-allergic drugs: a possible mechanism of action. Br Med J 1:820–821

    PubMed  CAS  Google Scholar 

  • Fournie GJ, Conte J J, Delsol G Fabre J, Migueres J, Jover A (1978) Systemic lupus erythematosus and malignant histiocytosis. Lancet II: 1305–1306

    PubMed  CAS  Google Scholar 

  • Fouts JR, Kamm JJ, Brodie BB (1957) Encymatic reductions of protosil and other azodyes. J Pharmacol Exp Ther 120:291

    PubMed  CAS  Google Scholar 

  • Franklin JL, Rosenberg IH (1973) Impaired folic acid absorption in inflammatory bowel disease: effects of salicylazosulphapyridine (Azulfidine). Gastroenterology 64:517–525

    PubMed  CAS  Google Scholar 

  • Freeman JB, Egan MC, Millis BJ (1976) The elemental diet. Surg Gynecol Obstet 142:925

    PubMed  CAS  Google Scholar 

  • Friedman M, Strang LB (1966) Effect of long-term corticosteroids and corticotrophin on the growth of children. Lancet II: 568–572

    Google Scholar 

  • Friedman M, Hinton JM, Lennard-Jones JE (1969) Adrenal and clinical responses to corticotrophin and prednisone in inflammatory disease of the colon. Gut 10:194–197

    PubMed  CAS  Google Scholar 

  • Fromm H, Gebel M, Schroeter V, Kanzler H, Schmidt FW (1978) Zur Behandlung des Morbus Crohn im akuten Stadium, Ergebnisse einer Diättherapie. Dtsch Med Wochenschr 103:377–380

    PubMed  CAS  Google Scholar 

  • Gabrielson AE, Good RA (1967) Chemical suppression of adaptive immunity. Adv Immunol 6:91–229

    Google Scholar 

  • Gange RW, Black MM, Carrington P, McKerron R (1977) Defective neutrophil migration in sarcoidosis. Lancet II:379–381

    PubMed  CAS  Google Scholar 

  • Gardner MR, Bargen J A (1964) Hemolytic anaemia secondary to salicylazosulfapyridin therapy. J Am Med Assoc 190:71

    CAS  Google Scholar 

  • Gazzard BG, Price HC, Dawson AM (1977) Social toll of Crohn’s disease. Gut 18:988

    Google Scholar 

  • Gazzard BG, Saunders B, Dawson AM (1978) Diets and stoma function. Br J Surg 65:642–644

    PubMed  CAS  Google Scholar 

  • Geffroy Y, Collin R, Hecketsweiler P, Segrestin M (1971) Traitement de la maladie de Crohn par le BCG. Données biologiques — essai d’interpretation. Arch Fr Mai App Dig 299–308

    Google Scholar 

  • Geyer RP (1960) Parenteral Nutrition. Physiol Rev 40:150

    PubMed  CAS  Google Scholar 

  • Gleeson MH, Bloom SR, Polak RM, Henry K, Dowling RH (1971) Endocrine tumor in kidney effecting small bowel structure, motility and absorptive function. Gut 12:773–782

    PubMed  CAS  Google Scholar 

  • Gleeson MH, Cullen JH, Dowling RH (1972) Intestinal structure and function after small bowel by-pass in the rat. Clin Sci 43:731–742

    PubMed  CAS  Google Scholar 

  • Gibbs AR, Seal RME (1978) Lymphoma after S.L.E. Lancet II: 1046

    PubMed  CAS  Google Scholar 

  • Gill AM, Kenyon UJ (1959) Continous use of prednisolone in the treatment of ulcerative colitis. Am J Gastroenterol 32:701

    PubMed  CAS  Google Scholar 

  • Giorgini GL, Stephens RV, Thayer WR (1973) The use of “medical by-pass“ in the therapy of Crohn’s disease: report of a case. Am J Dig Dis 18:153

    PubMed  CAS  Google Scholar 

  • Gleichmann H, Gleichmann E (1973 a) Immunosuppression and neoplasia. I. A critical review of experimental carcinogenesis and the immune-surveillance theory. Klin Wochenschr 51:255–259

    PubMed  CAS  Google Scholar 

  • Gleichmann E, Gleichmann H (1973 b) Immunosuppression and neoplasia. II. Is deficient immunsurveillance the only mechanism by which immunosuppression promotes neoplasia? A speculative review. Klin Wochenschr 51:260–265

    PubMed  CAS  Google Scholar 

  • Golde DW (1968) Aetiology of regional enteritis. Lancet I:1144–1145

    PubMed  CAS  Google Scholar 

  • Goldgraber MB, Kirsner JB, Palmer WL (1957) The role of ACTH and adrenal steroids in perforation of the colon in ulcerative colitis. A clinico-pathologic study. Gastroenterology 33:434–450

    PubMed  CAS  Google Scholar 

  • Goldman P, Peppercorn MA (1975) Drug therapy, Sulfasalazine. N Engl J Med 293:20–23

    PubMed  CAS  Google Scholar 

  • Goldstein MJ, Melamed MR, Grabstald H, Sherlock P (1967) Progressive villous atrophy of the ileum used as a urinary conduit. Gynecol Obstet 61:693–705

    Google Scholar 

  • Goligher JC, Dombal FT de, Watts JM, Watkinson G (1968) Ulcerative colitis. Bailliere, Tindall & Cassell, London

    Google Scholar 

  • Goode A, Hawkins T, Fegetter JGW, Johnson ID (1976) Use of an elemental diet for long-term nutritional support in Crohn’s disease. Lancet 1:122–124

    PubMed  CAS  Google Scholar 

  • Gorbach SL, Nahas L, Plaut G, Weinstein L (1967) Studies of intestinal microflora. V. Fecal microbial ecology in ulcerative colitis and regional enteritis: relationship to severity of disease and chemotherapy. Gastroenterology 54:575

    Google Scholar 

  • Gould SR (1975) Prostaglandins, ulcerative colitis, and sulphasalazine. Lancet 11:988

    Google Scholar 

  • Gould SR (1976) Assay of prostaglandine-like substances in faeces and their measurement in ulcerative colitis. Prostaglandines 11: 489–497

    CAS  Google Scholar 

  • Gould SR (1978) Salicylate and ulcerative colitis. Lancet II: 1161

    PubMed  CAS  Google Scholar 

  • Gould SR, Lennard-Jones JE (1976) Production of prostaglandines in ulcerative colitis and their inhibition by sulphasalazine. Gut 17:828

    Google Scholar 

  • Gould SR, Brash AR, Conoly ME (1977) Increased prostaglandin production in ulcerative colitis. Lancet II:98

    PubMed  CAS  Google Scholar 

  • Greaves MW, Skillen AW (1970) Effect of long-continued ingestions of zinc sulphate in patients with venous leg ulceration. Lancet II:889–891

    PubMed  CAS  Google Scholar 

  • Green JA, Dawson AA, Walker W (1978) Systemic lupus erythematosus and lymphoma. Lancet 11:753–755

    Google Scholar 

  • Greenberg GR, Haber GB, Jeejeehoy KN (1976) Total parental nutrition (TPN) and bowel rest in the management of Crohn’s disease. Gut 17:828

    Google Scholar 

  • Grieve J (1979) Male inpertility due to sulphasalazine. Lancet II: 464

    PubMed  CAS  Google Scholar 

  • Griffiths ID, Kane SP (1977) Sulphasalazine-induced lupus syndrome in ulcerative colitis. Br Med J IV:1188–1189

    Google Scholar 

  • Grove DI, Mahmoud AA, Warren KS (1976) Suppression of cell-mediated immunity by metronidazole. Clin Res 24:285 A

    Google Scholar 

  • Grundman MJ, Williams SE, Turnberg LA (1978) Double-blind controlled trial of disodium cromoglycate (DSCG) in the treatment of Crohn’s disease. Gut 19:963

    Google Scholar 

  • Gudmand-Hoyer E, Jarnum S (1970) Incidence and clinical significance of lactose malabsorption in ulcerative colitis and Crohn’s disease. Gut 11:338–343

    PubMed  CAS  Google Scholar 

  • Gudmand-Hoyer E, Binder V, Söltoft J (1975) The small intestinal disaccharidas activity in ulcerative colitis. Scand J Gastroenterol 10:209–212

    PubMed  CAS  Google Scholar 

  • Hallböök T, Lanner E (1972) Serum-zinc and healing of venous leg ulcers. Lancet II: 780—782

    PubMed  Google Scholar 

  • Halvorsen S, Myren J, Aakvaag A (1969) On the absorption of prednison and prednisolone disodium phosphate after rectal administrations. Scand J Gastroenterol 4:582–584

    PubMed  CAS  Google Scholar 

  • Hanngren A, Hansson E, Svartz N, Ullberg S (1963) Distribution and metabolism of salicyl-azosulfapyridine. I. A study with C14–salicyl-azosulphapyridine and C14–5 ammo-salicylic acid. Acta Med Scand 173:61

    PubMed  CAS  Google Scholar 

  • Harris DW, Swan CHJ (1977) Increased synthesis of prostaglandines in ulcerative colitis. Lancet II: 196

    PubMed  CAS  Google Scholar 

  • Harris J, Arch&ong EO, Clark CG (1972) The effect of salazopyrin on water and electrolyte transport in the human colon measured in vivo and in vitro. Gut 13:855

    PubMed  CAS  Google Scholar 

  • Hartmann F, Steinhart HJ, Malchow H (1977) Vollresorbierbare synthetische Nahrung mit Oligo-peptiden-Adjuvans in der Therapie bei chronisch entzündlichen Darmerkrankungen. Verh Dtsch Ges Inn Med 83:459–462

    PubMed  CAS  Google Scholar 

  • Harvey RF, Head AE (1973) Effect of cholecystokinin on colonic motility and symptoms in patients with the irritable bowel syndrome. Lancet I:1

    PubMed  CAS  Google Scholar 

  • Heatley RV, Calcraft BJ, Rhodes J, Owen E, Evans B (1974) Treatment of chronic proctitis with disodium cromoglycate. Gut 15:829

    PubMed  CAS  Google Scholar 

  • Heatley RV, Calcraft BJ, Rhodes J, Owen E, Evans BK (1975) Disodium cromoglycate in the treatment of chronic proctitis. Gut 16:559–563

    PubMed  CAS  Google Scholar 

  • Heaton KW, Thorton JR, Emmet PM (1979) Dietary, factors in Crohn’s disease. Z Gastroenterol 17:Suppl 140

    Google Scholar 

  • Heel RC, Brodgen RN, Speight TM, Avery GS (1978) Loperamide: a review of its pharmacological properties and therapeutic efficacy in diarrhoea. Drugs 15:33–52

    PubMed  CAS  Google Scholar 

  • Hees PAM van, Tuinte JHM, Rossum JM van, Tongeren JHM van (1979) Influence of intestinal transit time on azo-reduction of salicylazosulphapyridine (Salazopyrin). Gut 20:300

    PubMed  Google Scholar 

  • Herraiz-Ballesteroly, Simkin-Zmud B (1961) Un nuero antiserotonicio en el tratamiento del asma, jaqueca, colitis grave y enfermedacles reumaticas. Prev Med Argent 48:89

    Google Scholar 

  • Hershenson LM, Hershenson A (1961) Rectal hydrocortisone for ulcerative colitis refractory to oral corticosteroide. Am J Dig Dis 6:511

    PubMed  CAS  Google Scholar 

  • Hightower NC, Broders AC, Haines RD, McKenney JF, Sommer AW (1958) Anonic ulcerative colitis. III. Treatment. Am J Dig Dis 3:931

    Google Scholar 

  • Hill GL, Mair SJ, Edwards JP, Goligher JC (1976) Decreased typsin and bile acid in ileal fistulas drainage during the administration of a chemically defined liquid elemental diet. Br J Surg 63:133

    PubMed  CAS  Google Scholar 

  • Hodgkinson DJ, Williams TJ (1977) Case report. Endometrial carcinoma associated with azathioprine and cortisone therapy. Gynecol Oncol 5:308–312

    PubMed  CAS  Google Scholar 

  • Hofmann A (1978) The enterohepatic circulation of bile acids. In: Sleisinger M, Fordtran JS (eds) Gastrointestinal disease. Saunders, London Philadelphia, Toronto pp 418–429

    Google Scholar 

  • Holdstock DJ, Misiewicz J J, Waller SL (1969) Observations on the mechanism of abdominal pain. Gut 10:19

    PubMed  CAS  Google Scholar 

  • Holm G, Perlmann P (1968) The effect of antimetabolites on the cytoxicity by human lymphocytes. In: Dansset J, Hamburger J, Mathe G (eds) Advance in transplantation

    Google Scholar 

  • Husain SL (1969) Oral zinc sulphate in leg ulcers. Lancet I:1069–1071

    PubMed  CAS  Google Scholar 

  • Isalo E (1962) Therapeutical trials with monoaminooxydase in ulcerative colitis. Nord Med 67:219

    Google Scholar 

  • Jacobs E, Paulet P, Rahier J (1978) Hypersensitivity reaction to sulfasalazine — another case. Gastoenterology 75:1193

    CAS  Google Scholar 

  • Järnerot G (1980) Salazopyrin, use during laction. XI. Int. Congr. of Gastroenterology, A.S.N.E.M.G.E.

    Google Scholar 

  • Järnerot G, Into-Malmberg MB (1979) Sulphasalazine treatment during breast feeding. Scand J Gastroenterol 14:869

    PubMed  Google Scholar 

  • Jalan KN, Prescott RJ, Smith AN, Sircus W, McManus JPA, Small WP, Falconer CWA (1970)Influence of corticosteroids on results of surgical treatment for ulcerative colitis. N Engl J Med 282:588

    PubMed  CAS  Google Scholar 

  • James AH (1977) Breakfast and Crohn’s disease. Br Med J 1:943

    PubMed  CAS  Google Scholar 

  • Jarnum S (1976) Chemically defined diets in medicine. Nutr Metab 20:(Suppl 1) 19

    Google Scholar 

  • Jarnum S, Jensen KB (1975) Fecal radioiodine excretion following intravenous injection of 131-J-Albumin and 125-J-Immuneoglobin G in chronic inflammatory bowel disease An aid to topographic diagnosis. Gastroenterology 68:1433–1444

    PubMed  CAS  Google Scholar 

  • Jaup BH (1978) Salazosulfapyridin — induziertes Lupus — erythematodes Syndrom bei Colitis ulcerosa. Dtsch Med Wochenschr 103:1211–1213

    PubMed  CAS  Google Scholar 

  • Jewell DP, Truelove SC (1972 a) Circulating antibodies to cow’s milk proteins in ulcerative colitis. Gut 13:796–801

    PubMed  CAS  Google Scholar 

  • Jewell DP, Truelove SC (1972 b) Reaginic hypersensitivity in ulcerative colitis. Gut 13:903–906

    PubMed  CAS  Google Scholar 

  • Jewell DP, Truelove SC (1972c) Azathioprine in ulcerative colitis: an interim report on a controlled therapeutic trials. Br Med J I:709–712

    PubMed  CAS  Google Scholar 

  • Jewell DP, Truelove SC (1974 a) Azathioprine in ulcerative colitis: final report of controlled therapeutic trial. Br Med J IV: 627–630

    PubMed  CAS  Google Scholar 

  • Jewell DP, Truelove SC (1974 b) Azathioprine in ulcerative colitis. Gut 15:323

    Google Scholar 

  • Johnson LR (1974) Effect of gut hormones on growth of gastrointestinal mucosa. In: Chey WY, Brooks FP (eds) Endocrinology of the gut. Slack, Thorofare New Jersey, pp 163–177

    Google Scholar 

  • Johnson LR, Guthrie P (1976) Effect of cholecystokinin and 16, 16-dimethyl-prostaglandine E2on RNA and DNA of gastric and duodenal mucosa. Gastroenterology 70:59–65

    PubMed  CAS  Google Scholar 

  • Jones JH, Lennard-Jones JE, Misiewicz JJ (1965) Modified technique for administration of retention enemata in colitis. Gut 6:514

    PubMed  CAS  Google Scholar 

  • Jones JH, Friedman M, Hinton JM, Lennard-Jones JE (1969) The use of plasma Cortisol estimations in the management of colitis. Proc R Soc Med 62:497–499

    CAS  Google Scholar 

  • Jones R, Ryan A J, Wright SE (1964) The metabolism and excretion of tartrazine in the rat, rabbit, and man. Food Cosmet Toxicol 2:447

    PubMed  CAS  Google Scholar 

  • Juhl R, Summers RW, Blaug S, Guillory JK (1975) Diminished urinary digoxin excretion after salicylazosulfapyridine. Fed Proc 34:916

    Google Scholar 

  • Kallner S (1942) The cyanosis developing during treatment with sulfanilamide preparations. Acta Med Scand Suppl CXXX

    Google Scholar 

  • Kane SP (1976) Ileocolitis responding to bowels sterilization. Proc R Soc Med 69:266

    PubMed  CAS  Google Scholar 

  • Kaplan HP, Portnoy B, Binder HJ, Amatruda T, Spiro H (1975) A controlled evaluation of intravenous adrenocorticotrophic hormone and hydrocortisone in the treatment of acute colitis. Gastroenterology 69:91–95

    PubMed  CAS  Google Scholar 

  • Kasisch A (1963) Clinical evaluation of noncholone propionate in patients with gastrointestinal disease. Am J Gastroenterol 40:628

    Google Scholar 

  • Kasper H (1976) Diätbehandlung bei gastroenterologischen Erkrankungen. Verh Dtsch Ges Inn Med 82:742–750

    PubMed  Google Scholar 

  • Keren DF, Elliott HL, Brown GD, Yardley JH (1975) Atrophy of villi with hypertrophy and hyperplasia of Paneth cells in isolated (Thiry-Vella) ileal loops in rabbits. Gastroenterology 68:83–93

    PubMed  CAS  Google Scholar 

  • Kiefer ED (1960) A.C.T.H. and the corticosteroid hormones in the management of chronic ulcerative colitis. Med Clin North Am 44:567

    PubMed  CAS  Google Scholar 

  • Kirsner JB (1970) Ulcerative colitis 1970 — Recent developments. Scand J Gastroenterol 5:63

    Google Scholar 

  • Kirsner JB, Palmer JA, Spencer RO, Bicks ChF, Johnson ChF (1959) Corticotrophin (A.C.T.H.) and the adrenal steroids in the management of ulcerative colitis. Observations in 240 patients. Ann Intern Med 50:891

    PubMed  CAS  Google Scholar 

  • Kirsner JB, Scheffner AL, Palmer WL (1959a) Current-concepts of the medical managements of ulcerative colitis. J Am Med Assoc 169:433

    PubMed  CAS  Google Scholar 

  • Knudsen L, Christiansen L, Jarnum S (1976) Early complications in patients previously treated with corticosteroids. Scand J Gastroenterol Suppl 37:123–128

    PubMed  CAS  Google Scholar 

  • Korelitz BI (1980) Therapy of inflammatory bowel disease, including use of immunosuppressive agents. Clin Gastroenterol. 9:331

    PubMed  CAS  Google Scholar 

  • Korelitz BI, Lindner AE (1964) The influence of corticotrophin and adrenal steroids on the course of ulcerative colitis. Gastroenterology 46:671

    PubMed  CAS  Google Scholar 

  • Korelitz RL, Meyer JH (1980) Elemental diets — facts and fantasies. Gastroenterology 78:393

    Google Scholar 

  • Korelitz BI, Sommers SC (1976) Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and mucosal cell count. Am J Dig Dis 21:441–447

    PubMed  CAS  Google Scholar 

  • Korelitz BI, Glass JL, Wisch N (1973) Long-term immunosuppressive therapy in ulcerative colitis. Am J Dig Dis 18:317–322

    PubMed  CAS  Google Scholar 

  • Korelitz BI, Wisch N, Glass JL, Present DH (1978) Long-term response of Crohn’s disease to treatment with 6 mercaptopurine. Gastroenterology 74:1130

    Google Scholar 

  • Kraft SC, Kirsner JB (1971) Immunological apparatus of the gut and inflammatory bowel disease. Gastroenterology 60:922–951

    PubMed  CAS  Google Scholar 

  • Krieg ER, Meyer zum Biischenfelde KH (1976) Verlaufsbeobachtungen bei Patienten mit Morbus Crohn nach operativer bzw. unter immunosuppressiver Therapie. Verh Dtsch Ges Inn Med 82:924–927

    PubMed  Google Scholar 

  • Kristensen M, Koudahl G, Fischerman K, Jarnum S (1974) High dose prednisone treatment in severe ulcerative colitis. Scand J Gastroenterol 9:177–183

    PubMed  CAS  Google Scholar 

  • Kuhlmann F (1963) Pathogenetische und therapeutische Probleme der Colitis ulcerosa. Z Aerztl Fortbild (Jena) 52:15

    Google Scholar 

  • Labhart A (1971) Klinik der inneren Sekretion. 2. Aufl. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Landor JH (1969) Intestinal resection in gastric secretion in dogs with antrectomy. Arch Surg 98:645–646

    PubMed  CAS  Google Scholar 

  • Laursen ML (1978) The influence of salicylazosulfapyridine on the immune response to antigen tumour cells inoculated onto the coecal lumen of C3H mice. Scand J Gastroenterol 13:991

    PubMed  CAS  Google Scholar 

  • Law DH, Steinberg H, Sleisenger MH (1961) Ulcerative colitis with onset after the age of fifty. Gastroenterology 14:457

    Google Scholar 

  • Lee DAH, Taylor GM, James HT, Walker G (1979) Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21-phosphate as a retention enema. Gut20:349

    PubMed  CAS  Google Scholar 

  • Lendrum R, Walker JG, West B, Hill MJ (1974) Effect of sulphasalazine (Salazopyrin) on faecal flora in patient with inflammatory bowel disease. Gut 15:344

    PubMed  CAS  Google Scholar 

  • Lehner T, Wilton JMA, Ivanyi L (1976) Double-blind crossover trial of levamisole in recurrent aphthous ulceration. Lancet II: 926–929

    PubMed  CAS  Google Scholar 

  • Lennard-Jones JE (1977) Sulphasalazine in asymptomatic Crohn’s disease. A multicentre trial. Gut 18:69–72

    PubMed  CAS  Google Scholar 

  • Lennard-Jones JE, Powell-Tuck J (1979) Drug treatment in inflammatory bowel disease. Clin Gastroenterol 8:187–217

    PubMed  CAS  Google Scholar 

  • Lennard-Jones JE, Longmore AJ, Newell AC, Wilson CWE, Jones FA (1960) An assessment of prednisone, salazopyrin, and topical hydrocortisone hemisuccinate used as out-patient treatment of ulcerative colitis. Gut 1:217

    PubMed  CAS  Google Scholar 

  • Lennard-Jones JE, Baron JH, Connell AM, Jones FA (1962) A double-blind trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis. Gut 3:207–210

    PubMed  CAS  Google Scholar 

  • Lennard-Jones JE, Misiewicz JJ, Connell AM, Baron JH, Jones FA (1965) Prednisone as a maintenance treatment for ulcerative colitis in remission. Lancet I:188–189

    PubMed  CAS  Google Scholar 

  • Levi AJ, Fisher AM, Hughes L, Hendry WF (1979) Male infertility due to sulphasalazine. Lancet II:276

    PubMed  CAS  Google Scholar 

  • Levy G, Leonards JR, Procknal AJ (1957) Interpretation of in vitro dissolution data relative to gastrointestinal absorption characteristics of drugs in tablets. J Pharm Sci 56:1365

    Google Scholar 

  • Lewis GP, Piper PJ (1975) Inhibition of release of prostaglandines as an explanation of some of the actions of anti-inflammatory corticosteroids. Nature 254:308–311

    PubMed  CAS  Google Scholar 

  • Lewis GP, Jusko P, Burke WJ, Graves L (1971) Prednison side-effects and serum protein levels. A collaborative study. Lancet II:778–780

    PubMed  CAS  Google Scholar 

  • Lezoche E, Vagni V, Esperanza V (1978) Elevated vasoactive intestinal polypeptide (VIP) levels in patients with the short bowel syndrome (SBS). Gastroenterology 74:1132

    Google Scholar 

  • Loran MR, Carbone JV (1968) The humoral effect of intestinal resection on cellular proliferation and maturation in parabiotic rats. In: Sullivan MP (ed) Gastrointestinal radiation injury. Excerpta Medica, Amsterdam, pp 127–141

    Google Scholar 

  • Lubran M, McAllen PM (1951) Potassium deficiency in ulcerative colitis. Q J Med 20:22

    Google Scholar 

  • Mackay IR, Wall AJ, Goldstein G (1966) Response to Azathioprin in ulcerative colitis. Am J DigDis 11:536–545

    CAS  Google Scholar 

  • MacDougall J (1963) Treatment of ulcerative colitis with rectal steroids. Lancet I:826

    Google Scholar 

  • MacGregor RB, Sheagren JN, Lipsett MP, Wolff SM (1969) Alternate-day prednisone therapy. Evoluation of delayed hypersensitivity responses, control of disease and steroid side-effect. N Engl J Med 280:1427

    PubMed  CAS  Google Scholar 

  • MacKay IR, Wall AJ, Goldstein G (1966) Response to Azathioprine in ulcerative colitis. Am J DigDis 2:537

    Google Scholar 

  • Magyar I, Kovacs A (1970) Die Behandlung der Colitis ulcerosa. Dtsch Med Wochenschr 95:2375

    PubMed  CAS  Google Scholar 

  • Mainguet P, Fiasse R (1977) Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection. Gut 18:575–579

    PubMed  CAS  Google Scholar 

  • Makinodan T, Santos GW, Quinn RP (1970) Immunosuppressive drugs. Pharmacol Rev 22:189–247

    PubMed  CAS  Google Scholar 

  • Mani V, Lloyd G, Green FHY, Fox H, Turnberg LA (1976) Treatment of ulcerative colitis with oral disodium cromoglycate. A double-blind controlled trial. Lancet I:439–441

    PubMed  CAS  Google Scholar 

  • Markus J A, Wright LT, Strax S (1949) Treatment of chronic non-specific ulcerative colitis with aureomycin. A preliminary report. Am J Med 7:180

    Google Scholar 

  • Martini GA, Brandes JW (1976) Increased consumption of refined carbohydrates in patients with Crohn’s disease. Klin Wochenschr 54:367–371

    PubMed  CAS  Google Scholar 

  • Matts SGF (1961) Intrarectal treatment of 100 cases of ulcerative colitis with prednisolone-21-phosphate eremato. Br Med J I:165

    PubMed  CAS  Google Scholar 

  • Matts SGF (1962) Combined steroid therapy of fulminating ulcerative colitis. Br Med J I:1045

    Google Scholar 

  • Matts SGF, Flavell W (1962) Betamethasone enemata in ulcerative colitis. Gut 3:312–314

    PubMed  CAS  Google Scholar 

  • Matts SGF, Wharton BA, Kelleher J, Walters G (1963) Adrenal cortical and pituitary function after intrarectal steroid therapy. Br Med J I:24

    Google Scholar 

  • Mayberry JF, Rhodes J, Newcombe RG (1978) Breakfast and dietary aspects of Crohn’s disease. Br Med J IV: 1401

    Google Scholar 

  • McArdle HH, Echave W, Brown RA, Thompson AG (1974) Effect of elemental diet on pancreatic secretion. Am J Surg 128:690

    PubMed  CAS  Google Scholar 

  • Mekhjian HS, Phillips SF, Hofmann AF (1971) Colonic secretion of water and electrolytes induced by bile acid: perfusion studies in man. J Clin Invest 50:1569–1577

    CAS  Google Scholar 

  • Mekhjian HS, Smitz DM, Rankin GB, Deren JJ, Singleton JW (1978) National Cooperative Crohn’s Disease Study (NCCDS): factor determining recurrence rate after surgery. Gastroenterology 74:1066

    Google Scholar 

  • Meneloff AI (1967) Comment on: Intermittent steroid therapy for ulcerative colitis. Gastroenterology 53:801

    Google Scholar 

  • Menge H, Gräte M, Lorez-Meyer H, Riecken EO (1975) The influence of food intake on the development of structural and functional adaption following ileal resection in the rat. Gut 10:468

    Google Scholar 

  • Menge H, Robinson JWC, Riecken EO (1976) Anpassungsmöglichkeiten der Dünndarmschleimhaut an verschiedene intraluminale Milieuveränderungen. Z Gastroenterol 14:24

    Google Scholar 

  • Mennie AT, Dalley VM, Dinneen LC, Collier HO J (1975) Treatment of radiation-induced gastrointestinal distress with acetylsalicylate. Lancet II:942–943

    PubMed  CAS  Google Scholar 

  • Meyer-Rohn J (1969) Persönliche Mitteilung

    Google Scholar 

  • Meyers S, Janowitz HD (1978) The place of steroids in the therapy of toxic megacolon. Gastroenterology 75:729–731

    PubMed  CAS  Google Scholar 

  • Michlmayr G, Günther G, Lederer B, Huber H (1973) Malignes Lymphom nach zweijähriger immunsuppressiver Therapie einer Periarteriitis nodosa. Med Klin 68:180–182

    PubMed  CAS  Google Scholar 

  • Miller B, Fervers F, Rohbeck R, Stromeyer G (1976) Zuckerkonsum bei Patienten mit Morbus Crohn. Verh Dtsch Ges Inn Med 82:922–924

    PubMed  Google Scholar 

  • Misiewicz J J, Connell AM, Lennard-Jones JE (1964) Comparison of oral and rectal steroids in the treatment of proctocolitis. Proc R Soc Med 59:561–562

    Google Scholar 

  • Misiewicz JJ, Lennard-Jones JE, Connell AG, Baron JH, Jones FA (1965) Controlled trial of sulphasalazine in maintenance therapy of ulcerative colitis. Lancet I:185–188

    Google Scholar 

  • Misiewicz J J, Waller SL, Kiley N (1969) Effect of oral prostaglandin E 1 on intestinal transit in man. Lancet 1:648–651

    CAS  Google Scholar 

  • Mitchell J, Zuckerman L, Breuer RI (1977) The colon influences ileal resection diarrhoea. Gastroenterology 72:1103

    Google Scholar 

  • Mitelman F, Hartley B, Asp R, Ursing B (1976) Chromosome aberrations and metronidazole. Lancet II:802

    PubMed  CAS  Google Scholar 

  • Moertel CG, Bargen J A (1959) A critical analysis of the use of salicylazosulfapyridine in chronic ulcerative colitis. Ann Intern Med 51:897

    Google Scholar 

  • Molin L, Stendahl O (1979) The effect of sulfasalazine and its active components on human polymorphonuclear leukozyte function in relation to ulcerative colitis. Acta Med Scand 206:451

    PubMed  CAS  Google Scholar 

  • Montgomery RD, Frazer AC, Hood C, Goodhart JM, Holland MR, Schneider R (1968) Studies of intestinal fermentation in ulcerative colitis. Gut 9:521–526

    PubMed  CAS  Google Scholar 

  • Moore PK, Hoult JRS, Laurie AS (1978) Prostaglandins and mechanism of action of sulphasalazine in ulcerative colitis. Lancet II: 98–99

    PubMed  CAS  Google Scholar 

  • Moossa AR, Hall AW, Skinner DB, Winans CS (1976) Effect of fifty percent small bowel resection on gastric secretory function in rhesus monkey. Surgery 80:208–213

    PubMed  CAS  Google Scholar 

  • Mornington B (1977) Nebenwirkungen von Azathioprin (Imurek (R)) beim Menschen. 10. Europäischer Kongreß für Allergologie und klinische Immunologic Prag, September 1977

    Google Scholar 

  • Morrison LM (1953) Medical treatment of chronic ulcerative colitis. J Am Med Assoc 153:1580

    Google Scholar 

  • Moss A A, Carbone JV, Kressel HY (1977) Successful treatment of Crohn’s disease with broad spectrum antibiotics: initial and long-term results. Gastroenterology 72:83

    Google Scholar 

  • Mowat NAG, Douglas AS, Prunt PW, Mcintosh JAR, King PC, Boddy K (1973) Epsilon-aminocapronic acid therapy in ulcerative colitis. Am J Dig Dis 18:959–965

    PubMed  CAS  Google Scholar 

  • Mullen JL, Hargrove WC, Dudrick SJ, Fitts WT, Rosato EF (1978) Ten years experience with intervenous hyperalimentation and inflammatory bowel disease. Ann Surg 187:523–529

    PubMed  CAS  Google Scholar 

  • Müller-Wieland K (1966) Rektale Instillationen von Betamethason bei Colitis ulcerosa. Med Klin 61:597

    PubMed  Google Scholar 

  • Müller-Wieland K, Freyberger H (1968) Funktionelle Storungen bei chronisch-rezidivierender Kolitis und Proctosigmoiditis ulcerosa in der Remission. Z Gastroenterol 6:196

    Google Scholar 

  • Multicentre Trial (1971) Betamethasone 17-valerate and prednisolone 21-phosphate retention enemata in proctocolitis. Br Med J III:84–86

    Google Scholar 

  • Multicentre Trial (1977) Sulphasalazine in asymptomatic Crohn’s disease. Gut 18:69–72

    Google Scholar 

  • Nelson LE (1957) Über Colitis ulcerosa. Beitrag zum heutigen Stand der Therapie. Minn Med 40:552

    PubMed  CAS  Google Scholar 

  • Newton CR (1978) Effect of codeine phosphate, Lomotil and Isogel on ileostomy function. Gut 19:377–383

    PubMed  CAS  Google Scholar 

  • Neschis M, Siegelmann S, Parker JG (1968) Diagnosis and management of the megacolon of ulcerative colitis. Gastroenterology 55:251

    PubMed  CAS  Google Scholar 

  • Ng RP, Vicary FR (1976) Cell-mediated immunity and transfer factor in Crohn’s disease. Br Med J III:87–88

    Google Scholar 

  • Nord E, Douer D, Kessler E, Pinkhas J, Vries A de (1976) Sclerosing reticulum cell sarcoma following prolonged treatment with azathioprine for idiopathic thrombocytopenic purpura. Scand J Haematol 17:321–325

    PubMed  CAS  Google Scholar 

  • Norman AP, Sanders S (1969) Effect of corticotrophin on skeletal maturation and linear growth in six patients with severe asthma. Lancet I:287–289

    PubMed  CAS  Google Scholar 

  • Northfield TC, Roberts CI (1972) Intraabdominal abscesses due to azathioprine for Crohn’s disease. Gut 13:124–127

    PubMed  CAS  Google Scholar 

  • Nygaard K (1974) Small bowel resection and by-pass. In: Dowling RH, Riecken EO (eds) Intestinal adaption. Schattauer, Stuttgart New York, pp 47–57

    Google Scholar 

  • O-Donoghue DP, Dawson AM, Powell-Tuck J, Bown RL, Lennard-Jones JE (1978a) Double-blind withdrawal trial of azathioprine as maintenance treatment for Crohn’s disease. Lancet II: 955–957

    CAS  Google Scholar 

  • O’Donoghue DP, Dawson AM, Powell-Tuck J, Bown RL, Buckel NA, Burnham WR, Gould SR, Williams CB, Lennard-Jones JE (1978b) Azathioprine as a maintenance for Crohn’s disease: a double-blind withdrawal trial. Gastroenterology 74: A 1138

    Google Scholar 

  • Okada A, Takagi Y, Itakura T (1976) Skin lesions during intravenous hyperalimentation: Zinc deficiency. Surgery 80:629

    PubMed  CAS  Google Scholar 

  • O’Sullivan PM (1960) Topical corticosteroid therapy in ulcerative colitis. Can Med Assoc J 83:1295

    PubMed  Google Scholar 

  • Ota DM, Imbembo AL, Zuidema GD (1978) Total parenteral nutrition. Surgery 83:503–520

    PubMed  CAS  Google Scholar 

  • Parkinson DR, Cano PO, Jerry LM, Capek A, Shibata HR, Mansell PW, Glewis M, Marquis G (1977) Complications of cancer immunotherapy with levamisole. Lancet I:1129–1131

    PubMed  CAS  Google Scholar 

  • Patterson M (1958) Studies on the absorption of hydrocortisone from the colon of patients with idiopathic ulcerative colitis. Tex Rep Biol Med 16:508

    PubMed  CAS  Google Scholar 

  • Patterson M, McGivney J (1959) The treatment of nonspecific ulcerative colitis by the topical administration of the cortisteroids. Gastroenterology 36:480

    PubMed  CAS  Google Scholar 

  • Pelemans W, Vantrappen G (1976) A double-blind crossover comparison of loperamide with diphenoxylate in the symptomatic treatment of chronic diarrhea. Gastroenterology 70:1030–1034

    PubMed  CAS  Google Scholar 

  • Penn I, Hammond W, Brettschneider L (1969) Malignant lymphoma in transplantation patients. Transplant Proc I:106–112

    PubMed  CAS  Google Scholar 

  • Penn J (1974) Chemical immunosuppression and human cancer. Cancer 34:Suppl. 1474–1480

    PubMed  Google Scholar 

  • Peppercorn MA, Goldman P (1972) The role of intestinale bacteria in the metabolism of salicylazo-sulphapyridine. J Pharmacol Exp Ther 181:555

    PubMed  CAS  Google Scholar 

  • Peppercorn MA, Goldman P (1973) Distribution studies of salicylazosulphapyridine and its metabolites. Gastroenterology 64:240–245

    PubMed  CAS  Google Scholar 

  • Pepys J, Hargreave FE, Chan M, McCarthy DS (1968) Inhibitory effects of disodium cromoglycate on allergen inhalation tests. Lancet II: 134–137

    PubMed  CAS  Google Scholar 

  • Perl S (1977) Sulphasalazine-induced lupus syndrome in ulcerative colitis. Br Med J II: 1188

    Google Scholar 

  • Perrault J, Devroede G, Bounous G (1973) Effects of an elemental diet in healthy volonteers. Gastroenterology 64:569

    PubMed  CAS  Google Scholar 

  • Pieniaszek HJ, Bates TR (1976) Cholestyramine-induced inhibition of salicylazosulfapyridine (sulfasalazine) metabolism by rat intestinal microflora. J Pharmacol Exp Ther 198:240–245

    PubMed  CAS  Google Scholar 

  • Pories WJ, Henzel JH, Rob CG, Strain WH (1967) Acceleration of wound healing in man with zinc sulphate given by month. Lancet I:121–124

    PubMed  CAS  Google Scholar 

  • Pounder RE, Craven ER, Henthorn JS, Bannatyne JM (1975) Red cell abnomalities associated with sulphasalazine maintenance therapy for ulcerative colitis. Gut 18:181–185

    Google Scholar 

  • Powell-Tuck J, Lennard-Jones JE, May CS, Wilson CG, Patterson JW (1976) Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis. Br Med J I:193–195

    PubMed  CAS  Google Scholar 

  • Powell-Tuck J, Buckel NA, Lennard-Jones JE (1977) A controlled comparison of corticotrophin and hydrocortisone in the treatment of severe proctocolitis. Scand J Gastroenterol 12:971–975

    PubMed  CAS  Google Scholar 

  • Present DH, Wisch N, Glass JL, Korelitz BI (1977) The efficiency of immunosuppressive therapy in Crohn’s disease. A randomized long term double-blind study. Gastroenterology 72: A 91/1114

    Google Scholar 

  • Rachail M, Pellet R, Bruttmann G, Coulomb M, Faure H (1973) Le traitement de la maladie de Crohn par le BCG selon la méthode de Geoffroy. A propos de 8 observations. Sem Hôp (Paris) 49:3067–3071

    CAS  Google Scholar 

  • Radomski JL, Mellinger TJ (1962) The absorption, fate and excretion in rats of the watersoluble azo dyes, FD and C red no. 2, FD and T red no.4 and C yellow no. 6. J Pharmacol (Kyoto) 136:259

    CAS  Google Scholar 

  • Rafoth RJ (1974) Systemic granulomatous reaction to salicylazosulfapyridine (Azulfidine) in a patient with Crohn’s disease. Am J Dig Dis 19:465–469

    PubMed  CAS  Google Scholar 

  • Randall RA (1967) Renal failure following antibiotics. Ann Intern Med 66:1052–1053

    Google Scholar 

  • Rask-Madsen J (1973) Sieving characteristics of inflamed rectal mucosa. Gut 14:988–989

    PubMed  CAS  Google Scholar 

  • Rask-Madsen J, Bukhave K (1978) Indomethacin-responsive diarrhoea in irritable bowel syndrome. Gut 19: A 448

    Google Scholar 

  • Rault RM, Scribner BH (1977) Treatment of Crohn’s disease with home parenteral nutrition. Gastroenterology 72:1249–1252

    PubMed  CAS  Google Scholar 

  • Reilly J, Ryan J A, Strole W, Fischer JE (1976) Hyperalimentation in inflammatory bowel disease. Am J Surg 131:192–200

    PubMed  CAS  Google Scholar 

  • Riis P (1976) Prospective studies of medical treatment in Crohn’s disease (exemplified by personal experience with randomized trials). In: Westermann IT, Pena AS, Booth CC (eds) The management of Crohn’s disease. Excerpta Medica, Amsterdam Oxford, p 264

    Google Scholar 

  • Riis P, Anthonisen P, Wulff HR, Folkenborg O, Bonne vie O, Binder V (1972) The prophylactic effect of salazosulphapyridine in ulcerative colitis during long-term treatment. A double-blind trial on patients asymptomatic for one year. Scand J Gastroenterol 8:71–74

    Google Scholar 

  • Riis P, Binder V, Kirstensen M, Folkenborg O, Holtz A, Jarnum S (1979) The relapse-preventing effect of methyl-salazosulphapyridine compared to salazosulphapyridine during long-term treatment of ulcerative colitis. Scand J Gastroenterol 14:257

    PubMed  CAS  Google Scholar 

  • Rhodes J, Bainton D, Beck P, C&bell H (1971) Controlled trial of azathioprin in Crohn’s disease. Lancet 11:1273–1276

    Google Scholar 

  • Rhodes J, Smith RM, Hughes LE, Crosby DL, Rees B, Jones H, Heatley RV, Evans KT, Lawrie BW (1977) Effect of low dose steroids on clinical relaps in Crohn’s disease. Gut 18:952

    Google Scholar 

  • Robert A (1979) Cytoprotection by prostaglandins. Gastroenterology 77:761

    PubMed  CAS  Google Scholar 

  • Robinson OPW (1973) Metoclopramide — a new pharmacolopical approach? Postgrad Med J 49 (Suppl):9

    PubMed  Google Scholar 

  • Rocchio MA, Mo Cha CH, Haas KF (1974) Use of chemically defined diets in the management of patients with acute inflammatory bowel disease. Am J Surg 127:469

    PubMed  CAS  Google Scholar 

  • Rodgers JB, Bernard HR, Balint J A (1976) Colonic infusion in the management of the short bowel syndrome. Gastroenterology 70:186–189

    PubMed  CAS  Google Scholar 

  • Rosenberg JL, Levin B, Wall AJ, Kirsner JB (1975) A controlled trial of azathioprine in Crohn’s disease. Am J Dig Dis 20:721–726

    PubMed  CAS  Google Scholar 

  • Roth DA, Lindert MEF (1959) A fatal case of azulfidine-induced agranulocytose. Gastroenterology 37:787

    PubMed  CAS  Google Scholar 

  • Russel R (1975) Progress report: elemental diet. Gut 16:68

    PubMed  CAS  Google Scholar 

  • Sahi T (1978) Progress report: Dietary lactose and aetiology of human small intestinal hypolactasia. Gut 19:1074–1086

    PubMed  CAS  Google Scholar 

  • Salem SN, Truelove SC (1965) Small-intestinal and gastric abnormalities in ulcerative colitis. Br Med J 1:827–831

    PubMed  CAS  Google Scholar 

  • Salter RH, Read AE (1970) Epsilon-aminocapronic — acid therapy in ulcerative colitis. Gut 11:585–587

    PubMed  CAS  Google Scholar 

  • S&son PA, Brooke PN (1963) Absorption of hydrocortisone from large bowel. Lancet I:701

    Google Scholar 

  • Sanbar SS, West KM (1961) Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis. Lebanese Med J 14:380

    CAS  Google Scholar 

  • Scheiffarth F, Warnatz H (1969) Langzeitbehandlung von Immunopathien unter besonderer Berücksichtigung immunsuppressiver Medikamente. Dtsch Med Wochenschr 94:2444

    PubMed  CAS  Google Scholar 

  • Schein PS, Winokur SH (1975) Immunosuppressive and cytotoxic chemotherapy. Long-term complication. Ann Intern Med 82:84–85

    PubMed  CAS  Google Scholar 

  • Scheline R, Longberg RB (1965) The absorption, metabolism, and exaction of the sulfrated azo dye. Acid yellow, by rat. Acta Pharmacol (Kbh) 23:1

    CAS  Google Scholar 

  • Scheline RR, Nygaard RT (1970) Encymatic reduction of the azo dye. Acid yellow, by extracts of Streptococcus faecalis isolated from rat intestine. Food Cosmet Toxicol 8:55

    PubMed  CAS  Google Scholar 

  • Schmähl F (1971) Nebenwirkungen zytostatischer Therapie unter besonderer Berücksichtigung potentieller karzinogener Wirkungen. Internist 12:115–119

    PubMed  Google Scholar 

  • Schneider RE, Beeley L (1977) Megaloblastic anaemia associated with sulphasalazine treatment. Br Med J 11:1638–1639

    Google Scholar 

  • Schröder H, C&bellDES (1972 b) Absorption, metabolism and excretion of salicylazosulphapyridine in man. Clin Pharmacol Ther 13:539

    PubMed  Google Scholar 

  • Schroder H, Evans DA (1972 a) Acetylator phenotype and adverse effect of sulphasalazine in healthy subjects. Gut 13:278–284

    PubMed  CAS  Google Scholar 

  • Schulze-Delrieu K (1979) Metoclopramide. Gastroenterology 77:768

    CAS  Google Scholar 

  • Seelig LL, Winborn WB (1977) Effect of small bowel resection on the gastric mucosa in the rat. Gastroenterology 74:421–428

    Google Scholar 

  • Seelig LL, Winborn WB, Weser E (1978) Changes in gastric glandular cell kinetics after small bowel resection in the rat. Gastroenterology 74:1–6

    PubMed  CAS  Google Scholar 

  • Segal AW, Levy AJ, Loewi G (1977) Levamisole in the treatment of Crohn’s disease. Lancet II:382–384

    PubMed  CAS  Google Scholar 

  • Sharon P, Ligumsky M, Rachmilewitz D, Zorn V (1978) Role of prostaglandins in ulcerative colitis enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology 75:638–640

    PubMed  CAS  Google Scholar 

  • Silk DBA, Chung YC, Berger KL, Conley K, Beigler M, Sleisinger MH, Spiller GA, Kim YS (1979) Comparison of oral feeding of peptide and amino acid meals to normal human subjects. Gut 20:291

    PubMed  CAS  Google Scholar 

  • Singleton JW (1976) The National Cooperative Crohn’s Disease Study (NCCDS): Preliminary results of part I. Gastroenterology 70:A–80/938

    Google Scholar 

  • Singleton JW (1977) The National Cooperative Crohn’s Disease Study (NCCDS): Results of drug treatment. Gastroenterology 72: A–110/1133

    Google Scholar 

  • Singleton JW, Law DH, Kelley ML, Mekhjian HS, Sturdevant RAL (1979) National Cooperative Crohn’s Disease Study: Adverse reactions to study drugs. Gastroenterology 77:870

    PubMed  CAS  Google Scholar 

  • Singleton JW, Summers RW, Kern F, Becktel JM, Best WR, Hansen RN, Winship DH (1979) A trial of sulfasalazine as adjunctive therapy in Crohn’s disease. Gastroenterology 77:887

    PubMed  CAS  Google Scholar 

  • Smith AN, Balfour TW (1972) Malabsorption in Crohn’s disease. Clin Gastroenterol 1:433

    Google Scholar 

  • Smith PR, Dawson DJ, Swan CHJ (1978) Prostaglandins and sulphasalazine. Lancet II:260

    PubMed  CAS  Google Scholar 

  • Smith RC, Rhodes J, Heatley RV, Hughes LE, Crosby DL, Rees BI, Jones H, Evans KT, Lawrie BW (1978) Low dose steroids and clinical relapse in Crohn’s disease: a controlled trial. Gut 19:600–610

    Google Scholar 

  • Sodomann C-P, Gropp C (1979) Wie groß ist die Malignomgefahr durch Immunosuppressiva? Internist (Berlin) 20:571

    CAS  Google Scholar 

  • Solomons NW, Vo-Khactu K, Sandstead HH, Rosenberg IH (1974) Zinc nutrition in inflammatory bowel disease. In: Fifth World Congr. of Gastroenterology, Abstr. p 263. Mexican Society of Gastroenterology, Mexico City 1974

    Google Scholar 

  • Soong CS, Thompson JB, Poley JR, Hess DR (1972) Hydroxy fatty acid in human diarrhea. Gastroenterology 63:748–757

    PubMed  CAS  Google Scholar 

  • Sotolongo RP, Neefe LI, Rudzki C, Ishak KG (1978) Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity. Gastroenterology 75:95–99

    PubMed  CAS  Google Scholar 

  • Spencer J A, Kirsner JB (1960) Rectal obsorption of 6 alpha CI 4 —1+3 prednisolone. Proc Soc Exp Biol Med 103:74

    PubMed  CAS  Google Scholar 

  • Spencer JA, Kirsner JB (1962) Treatment of ulcerative colitis. Am J Gastroenterol 37:17

    PubMed  CAS  Google Scholar 

  • Spencer JA, Kirsner JB, Palmer WL (1960) Rectal absorption of 6-alpha-C14-H3 prednisolone. Proc Soc Exp Biol Med 103:74

    PubMed  CAS  Google Scholar 

  • Spencer J A, Mlynaryk KP, Reed PJ, Palmer WL (1962) Immediate and prolonged therapeutic effects of corticotrophin and adrenal steroids in ulcerative colitis: observation in 340 cases for periods up to ten years. Gastroenterology 42:113

    PubMed  CAS  Google Scholar 

  • Spiro HM (1960) Clinical and pathologic observations in steroidtreated ulcerative colitis. Am J Dig Dis 5:548

    PubMed  CAS  Google Scholar 

  • Spüth G, Nöcker J (1962) Die konservative Therapie der Colitis ulcerosa. Med Klin 57:794

    Google Scholar 

  • Staffer MH, Sauer WG, Dearing WH (1965) The spectrum of cholestatic hepatic disease. J Am Med Assoc 191:829–837

    Google Scholar 

  • Stephens RV, Randall HT (1969) Use of a concentrated, balanced, liquid elemental diet for nutritional management of catabolic states. Ann Surg 170:642

    PubMed  CAS  Google Scholar 

  • Straus E, Gerson CD, Yalow RS (1974) Hypersecretion of gastrin associated with the short bowel syndrome. Gastroenterology 66:175–180

    PubMed  CAS  Google Scholar 

  • Strax S, Markus JA, Wright LT (1951) Treatment of non-specific ulcerative colitis with aureomycin. Rev Gastroenterol 18:413

    PubMed  CAS  Google Scholar 

  • Streicher MH, Jackson GG, Kniering R (1953) Chronic ulcerative colitis, longtime studies on clinical and bacteriologic response to auremycin. Gastroenterology 23:572

    PubMed  CAS  Google Scholar 

  • Sturdevant RAL, Singleton JW, Deren JJ, Law DH, McCleery JL (1979) Azathioprine-related pancreatitis in patients with Crohn’s disease. Gastroenterology 77:883

    PubMed  CAS  Google Scholar 

  • Summers RW, Singleton JW (1977) National Cooperative Crohn’s Disease Study (NCCDS): a controlled prospective trial of three drugs as placebo. Gut 18:972–973

    Google Scholar 

  • Summers RW, Sessions JT, Switz DM, Singleton JW (1978) National Cooperative Crohn’s Disease Study (NCCDS): response of subgroups to drug treatment. Gastroenterology 74:1100

    Google Scholar 

  • Summers RW, Switz DM, Sessions JT, Becktel JM, Brest WR, Kern F, Singleton JW (1979) National Cooperative Crohn’s Disease Study: Results of rug treatment. Gastroenterology 77:847

    PubMed  CAS  Google Scholar 

  • Svartz N (1941) Ess. nyss. sulfonamid preparat. Nord Med 9:554

    Google Scholar 

  • Svartz N (1956) Die Behandlung der Colitis ulcerosa. Gastroenterologia 86:683

    PubMed  CAS  Google Scholar 

  • Svartz N (1960) In: Colitis ulcerosa. Panel-discussion. Int. Congr. of Gastroenterology, Leyden 1960

    Google Scholar 

  • Swarbrick ET, O’Donoghue DP (1979) Levamisole in Crohn’s disease. Lancet I:392

    PubMed  CAS  Google Scholar 

  • Swarbrick ET, Loose H, Lennard-Jones JE (1974) Enema volume is an important factor in successful topical corticosteroid treatment of colitis. Proc R Soc Med 67:753–754

    PubMed  CAS  Google Scholar 

  • Symington GR, Mackay ER, Lambert RP (1977) Cancer and teratogenesis: infrequent occurrence after medical use of immunosuppressive drugs. Aust NZ J Med 7:368–372

    CAS  Google Scholar 

  • Temperly JM, Stagg BH, Wylie JH (1971) Disappearance of gastrin and pentagastrin in the portal circulation. Gut 12:372–376

    Google Scholar 

  • Thayer WR, Charland C, Field C (1976) Salazopyrin and its effect on lymphocyte subpopulations and functions. Gastroenterology 70:942

    Google Scholar 

  • Thayer WR, Charland C, Field CE (1979) Effect of sulfasalazine on selected lymphocyte subpopulations in vivo and in vitro. Dig Dis Sci 24:672

    PubMed  CAS  Google Scholar 

  • Thirkettle JL, Gough R, Read AE (1963) Agranulocytosis associated with sulphasalazine (Salazopyrin) therapy. Lancet I:1395

    PubMed  CAS  Google Scholar 

  • Tompkins RK, Waisman J, Watt CMH, Corlin R, Keith R (1977) Absence of mucosal atrophy in human small intestine after prolonged isolation. Gastroenterology 73:1406–1409

    PubMed  CAS  Google Scholar 

  • Toth A (1979) Reversible toxic effect of salazosulfapyridine. Fertil Steril 31:538

    PubMed  CAS  Google Scholar 

  • Toth A (1979) Male infertility due to sulphasalazine. Lancet II:904

    PubMed  CAS  Google Scholar 

  • Traub AI, Thompson W, Carville J (1979) Male infertility due to sulphasalazine. Lancet II:639

    PubMed  CAS  Google Scholar 

  • Truelove SC (1958 a) Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium. Report on a controlled therapeutic trial. Br Med J II: 1072–1077

    PubMed  CAS  Google Scholar 

  • Truelove SC (1958 b) Treatment of ulcerative colitis with local hydrocortisone. Proc R Soc Med 51:429

    PubMed  CAS  Google Scholar 

  • Truelove SC (1960 a) Local corticosteroid treatment in severe attacks of ulcerative colitis. Br Med J I:102

    Google Scholar 

  • Truelove SC (1960 b) Systemic and local cortisonsteroid therapy in ulcerative colitis. Br Med J I:464–467

    PubMed  CAS  Google Scholar 

  • Truelove SC (1965) Ulcerative colitis provocated by milk. Br Med J I:154

    Google Scholar 

  • Truelove SC, Jewell DP (1974) Intensive intravenous regimen for severe attacks of ulcerative colitis. Lancet I:1067–1070

    PubMed  CAS  Google Scholar 

  • Truelove SC, Witts L-J (1955) Cortisone in ulcerative colitis. Final report on a therapeutic trial. Br Med J II:1041–1048

    PubMed  CAS  Google Scholar 

  • Truelove SC, Witts L-J (1959) Cortison and corticotropin in ulcerative colitis. Br Med J I:387

    PubMed  CAS  Google Scholar 

  • Truelove SC, Watkinson G, Draper G (1962) Comparison of corticosteroid and sulphasalazine therapy in ulcerative colitis. Br Med J II:1708–1711

    PubMed  CAS  Google Scholar 

  • Truelove SC, Willoughby CP, Lee EG, Kettlewell MGW (1978) Further experience in the treatment of severe attacks of Ulcerative colitis. Lancet II: 1086–1088

    PubMed  CAS  Google Scholar 

  • Turnberg LA (1979) The pathophysiology of diarrhoea. Clin Gastroenterol 8:551

    PubMed  CAS  Google Scholar 

  • Tydd TF, Dyer NH (1976) Sulphasalazine lung. Med J Aust 14:570–573

    Google Scholar 

  • Tytgat GN (1975) Loperamide and ileostomy output. Br Med J III:489

    PubMed  CAS  Google Scholar 

  • Tytgat GN, Huibregtse K (1975) Loperamide and ileostomy output: placebo-controlled double-blind crossover study. Br Med J II: 667

    PubMed  CAS  Google Scholar 

  • Ursing B, Kamme C (1975) Metronidazole for Crohn’s disease. Lancet I:775–777

    PubMed  CAS  Google Scholar 

  • Valentin N, Nelsen OV, Olesen KH (1975) Muscle cell electrolytes in ulcerative and Crohn’s disease. Digestion 13:284–290

    PubMed  CAS  Google Scholar 

  • Van der Waay D, Cohen BJ, Anver MR (1974) Mitigation of experimental inflammatory bowel disease in guinea pigs by selective elimination of the aerobic Gram-negative intestinal microflora. Gastroenterology 67:460

    Google Scholar 

  • Van Hees PA, van Elferen L, Margry R, van Rossum JM, van Tongeren JH (1976) Factors that may influence the effect of Salazopyrin. In: Weterman IT, Pena AS, Booth CC (eds) The management of Crohn’s disease. Excerpta Medica, Amsterdam Oxford, p 175

    Google Scholar 

  • Vicary FR, Chambers JD, Dhillon P (1979) Double-blind trial of the use of transfer factor in the treatment of Crohn’s disease. Gut 20:408

    PubMed  CAS  Google Scholar 

  • Voitk AJ, Echave V, Brown JH, Gurd FN (1973a) Experience with elemental diet in the treatment of inflammatory bowel disease. Arch Surg 107:329

    PubMed  CAS  Google Scholar 

  • Voitk AJ, Echave V, Brown RA, Gurd FN (1973b) Use of elemental diet during the adaptive stage of short gut syndrome. Gastroenterology 65:419–426

    PubMed  CAS  Google Scholar 

  • Vormittag W (1974) Zytostatische immunodepressive Therapie, chromosomale Aberrationen und karzinogene Wirkung. Wien Klin Wochenschr 86:69–75

    PubMed  CAS  Google Scholar 

  • Walker ARP, Walker BF (1969) Bowel motility and colonic cancer. Br Med J III:238

    PubMed  CAS  Google Scholar 

  • Walker SR, Evans ME, Richards AJ, Paterson JW (1972) The fate of (14 C) disodium cromoglycate in man. J Pharm Pharmacol 24:525–531

    PubMed  CAS  Google Scholar 

  • Ward M, McManus JPA (1975) Dapsone in Crohn’s disease. Lancet I:1236–1237

    PubMed  CAS  Google Scholar 

  • Watkinson G (1958) Treatment of ulcerative colitis with topical hydrocortisone hemisuccinate sodium. A controlled trial employing restricted sequential analysis. Br Med J II:1077–1082

    PubMed  CAS  Google Scholar 

  • Watkinson G (1961) Medical management of ulcerative colitis. Br Med J I:147

    PubMed  CAS  Google Scholar 

  • Watkinson G (1962) Dieärztliche Behandlung der Colitis ulcerosa. Med Klin 57:1469

    PubMed  CAS  Google Scholar 

  • Webster LT, Butterworth AE, Mahmoud AAF, Mngola EN, Warren KS (1975) Suppression of delayed hypersensitivity in schistosome-infected patients by niridazole. N Engl J Med 292:1144–1147

    PubMed  Google Scholar 

  • Weis J (1963) Investigation on some experimental inflammations in mouse paws. Med Exp 8:1

    PubMed  CAS  Google Scholar 

  • Weis J (1973) Determination of salicyl-azo-sulphapyridine, sulphapyridine and acetylated sulphapyridine in the serum and milk of a nursing mother. Internal Pharmacia Report Pharmacia AB, Uppsala

    Google Scholar 

  • Weissmann G (1967) The role of lysosomes in inflammation and disease. Ann Rev Med 18:97–112

    PubMed  CAS  Google Scholar 

  • Wenckert A, Kristensen M, Eklund AE, Barany F, Jarnum S, Worning H, Fokenborg O, Holtz A, Bonnevie O, Riis P (1976) The long-term prophylactic effect of salazosulphapyridine (Salazopyrin (R)) in primarily resected patients with Crohn’s disease. A controlled double-blind trial. Scand J Gastroenterol 11: Suppl 38, 93

    Google Scholar 

  • Wenckert A, Kristensen M, Eklund AE, Barany F, Jarnum S, Worning H, Folkenberg O, Holtz A, Bonnevie O, Riis P (1978) The long-term prophylactic effect of salazosulphapyridine (Salazopyrin) in primarily resected patients with Crohn’s disease. A controlled double-blind trial. Scand Gastroenterol 13:161–167

    CAS  Google Scholar 

  • Wesdorp E, Schellekens PTA, Weening R, Meuwissen SG, Tytgat GNJ (1977) Levamisole in Crohn’s disease — a double-blind controlled trial. Gut 18:971–972

    Google Scholar 

  • West B, Lendrum R, Hill, MJ, Walker G (1974) Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with inflammatory bowel disease. Gut 15:960–965

    PubMed  CAS  Google Scholar 

  • Whittington PF, Barnes V, Bay less TM (1977) Medical management of Crohn’s disease in adolescence. Gastroenterology 72:1338–1344

    PubMed  CAS  Google Scholar 

  • Wickbom G, Landor JH, Bushkin FL, McGuigan JE (1975) Changes in canine gastric and output and serum gastrin levels following massive small intestinal resection. Gastroenterology 69:448–452

    PubMed  CAS  Google Scholar 

  • Willoughby CP, Heyworth MF, Piris J, Truelove SC (1979) Comparison of disodium cormoglycate and sulfasalazine as maintenance therapy for ulcerative colitis. Lancet I:119–122

    PubMed  CAS  Google Scholar 

  • Willoughby JMT, Gyte GML (1976) Effect of azathioprine on cell-mediated immunity in Crohn’s disease. Gut 17:399

    PubMed  CAS  Google Scholar 

  • Willoughby JMT, Kumar PJ, Beckett J, Dawson AM (1971) Controlled trial of azathioprine in Crohn’s disease. Lancet II:944–947

    PubMed  CAS  Google Scholar 

  • Wilmanns W (1971) Immunbiologische Grundlagen der medikamentösen Immunsuppression. In: Ricken D, Schumacher K (Hrsg) Medikamentöse Immunsuppression. Thieme, Stuttgart

    Google Scholar 

  • Winawer SJ, Broitman SA, Wolochow DA, Osborne MP, Zamcheck N (1966) Successful management of massive-small bowel resection based on assessment of absorption defects and nutritional needs. N Engl Med 274:72–78

    CAS  Google Scholar 

  • Windsor CWO, Fejfar J, Woodward DAK (1969) Gastric secretion after massive small bowel secretion. Gut 10:779–786

    PubMed  CAS  Google Scholar 

  • Winitz M, Seedman DA, Graff J (1970) Studies in metabolic nutrition employing chemically defined diets. Am J Clin Nutr 23:525

    PubMed  CAS  Google Scholar 

  • Wittenborg A, Zeidler H, Geisthövel W (1973) Alternierende Corticoidtherapie bei chronischer Polyarthritis. Dtsch Med Wochenschr 98:919

    PubMed  CAS  Google Scholar 

  • Wood WA, Walters G, Matts SGF (1964) Urinary excretion of prednisolone after intrarectal therapy in ulcerative colitis. Br Med J II: 1045

    PubMed  CAS  Google Scholar 

  • Wretline A (1972) Complete intravenous nutrition. Nutr Metab [Suppl] 14:1–57

    Google Scholar 

  • Wright HK, Tilson MD (1973) Postoperative disorders of the gastrointestinal tract. Grune & Stratton, New York London

    Google Scholar 

  • Wright LT, Strax S, Markus JA (1950) Treatment of non-specific ulcerative colitis with aureomycin. Ann West Med Surg 4:717

    PubMed  CAS  Google Scholar 

  • Wright R (1970) Ulcerative colitis. Gastroenterology 58:875–897

    PubMed  CAS  Google Scholar 

  • Wright R, Truelove SC (1965 a) A controlled therapeutic trial of diets in ulcerative colitis. Br Med J II:138

    PubMed  CAS  Google Scholar 

  • Wright R, Truelove SC (1965 b) A controlled clinical trial of various types of diet in ulcerative colitis. Gut 6:203

    Google Scholar 

  • Wyburn-Mason R (1979) SLE and lymphoma. Lancet I:156

    PubMed  CAS  Google Scholar 

  • Young EA, Heuler N, Russell P, Weser E (1975) Comparative nutritional analysis of chemically defined diets. Gastroenterology 69:1338–1345

    PubMed  CAS  Google Scholar 

  • Zetzel L, Atin HL (1938) A.C.T.H. and adrenal corticosteroids in the treatment of ulcerative colitis. Am J Dig Dis 3:916

    Google Scholar 

Download references

Authors
  1. K. Müller-Wieland
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Braun
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Kinderklinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    F. Bläker

  2. Pharmakologisches Institut, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    W. Braun

  3. Radiologische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    E. Bücheler

  4. Zentrum Chirurgie, Abteilung Kinderchirurgie, Klinikum der Universität, Im Neuenheimer Feld 110, D-6900, Heidelberg, Deutschland

    R. Daum

  5. Chirurgische Universitätsklinik Amsterdam, Wilhelmina Gasthuis, NL-1054 EG, Amsterdam, The Netherlands

    R. J. A. M. van Dongen

  6. Radiologisches Institut, Stadtklinik, Balgerstr. 50, D-7570, Baden-Baden, Deutschland

    W. Erbe

  7. Abteilung für Allgemeine Chirurgie mit Poliklinik, Chirurgische Universitätsklinik, Hugstetter Straße 55, D-7800, Freiburg i. Br., Deutschland

    E. H. Farthmann

  8. Kantonsspital Luzern, Medizinische Klinik, Gastroenterologische Abteilung, der Universität Zürich, CH-6004, Luzern, Switzerland

    L. Filippini (Lehrbeauftragter) (Lehrbeauftragter)

  9. Innere Abteilung, Krankenhaus St. Josef, Bergstr. 6-12, D-5600, Wuppertal-Elberfeld, Deutschland

    F. H. Franken

  10. Zentrum Psychologische Medizin, Abteilung für Psychosomatik, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Deutschland

    H. Freyberger

  11. Pathologisches Institut, Kantonsspital Luzern, CH-6004, Luzern, Switzerland

    J.-O. Gebbers

  12. Division of Gastroenterology, The Scripps Clinic and Research Foundation, University of California, San Diego, La Jolla, CA, USA

    W. S. Haubrich M.D., F.A.C.P.

  13. Medizinische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    K. H. Hölze

  14. I. Medizinische Abteilung, Städtisches Krankenhaus Neuperlach, Oskar-Maria-Graf-Ring 51, D-8000, München 83, Deutschland

    W. Kühner

  15. Psychiatrische Klinik, ehemaliger Chefarzt der Klinik des Bernhard-Nocht-Instituts für Schiffs- und Tropenkrankheiten, Oderfelder Str. 6, D-2000, Hamburg 13, Deutschland

    W. Mohr

  16. Medizinische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    K. Müller-Wieland

  17. I. Medizinische Abteilung, Stadtisches Krankenhaus Neuperlach, Oskar-Maria-Graf-Ring 51, D-8600, München 83, Deutschland

    R. Ottenjann

  18. Medizinische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    H. F. Otto

  19. Physiologisches Institut, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    H. J. Roose

  20. Medizinische Klinik, Abteilung für Klinische Immunologic, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    E. Rumberger

  21. Medizinische Klinik, Abteilung für Klinische Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    W.-H. Schmiegel

  22. Chirurgische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    H. W. Schreiber

  23. Chirurgische Universitätsklinik Amsterdam, Wilhelmina Gasthuis, NL-1054 EG, Amsterdam, The Netherlands

    E.-D. Schwilden

  24. Abteilung für Gefäßchirurgie, z.Z. Städtische Krankenanstalten, Hirschlandstr. 97, D-7300, Esslingen a. Neckar, Deutschland

    E.-D. Schwilden

  25. Chirurgische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    N. Soehendra

  26. Chirurgische Universitätsklinik und Poliklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Deutschland

    F. Stelzner

  27. Medizinische Klinik, Abteilung für Klinische Immunologic, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    H.-G. Thiele

  28. Klinik für Innere Medizin, Abteilung für Gastroenterologie, Der Universität von Amsterdam, Wilhelmina Gasthuis, NL-1054 EG, Amsterdam, The Netherlands

    G. N. Tijtgat

  29. Chirurgische Abteilung, Kreiskrankenhaus, D-6640, Merzig, Deutschland

    B. Täger

  30. I. Medizinische Abteilung, Stadtisches Krankenhaus Neuperlach, Oskar-Maria-Graf-Ring 51, D-8000, München 83, Deutschland

    J. Weingart

  31. Chirurgische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    R. Winkler

  32. Medizinische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    Kurt Müller-Wieland

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Müller-Wieland, K., Braun, W. (1982). Konservative Therapie. In: Bläker, F., et al. Dickdarm. Handbuch der inneren Medizin, vol 3 / 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67945-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67945-2_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67946-9

  • Online ISBN: 978-3-642-67945-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation