Zusammenfassung
Sammelstatistiken haben gezeigt, daß Patienten mit einer Colitis ulcerosa in besonderem Maße Karzinom-gefährdet sind (GOLDGRABER et al. 1958 a, b; SLANEY u. BROOKE 1959; REIFFERSCHEID 1960; GOLDGRABER u. KIRSNER 1964). Die Colitis ulcerosa gilt anerkanntermaßen als KREBSRISIKOERKRANKUNG. Bereits 1925 diskutierten CROHN und ROSENBURG Zusammenhänge zwischen langjährigen totalen Kolitiden und der Entstehung kolo-rektaler Karzinome. 1928 beschrieb BARGEN die Entwicklung eines Kolonkarzinoms im Ablauf einer Colitis ulcerosa. Später fanden BARGEN et al. (1954) bei 1564 Kolitis-Patienten eine 30fach höhere Kolonkarzinom-Frequenz als in einer vergleichbaren Patienten-Gruppe ohne vorbestehende Colitis ulcerosa.
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Otto, H.F., Müller-Wieland, K., Gebbers, JO. (1982). Das Kolitis-Karzinom. In: Bläker, F., et al. Dickdarm. Handbuch der inneren Medizin, vol 3 / 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67945-2_22
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