Abstract
Purulent infections of bacterial origin are preferably treated by antibiotics which yield high concentrations, possibly even several times higher than the minimal inhibitory concentrations (MIC) of the relevant bacterial strains over a long period of time. Inactivation of these antibiotics by local factors such as binding to tissue proteins or degradation by enzymes for example should be as low as possible. Furthermore they must not cause severe side effects if applied in therapeutic dosages.
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Brückner, O., Collmann, H., Alexander, M., Wagner, J. (1981). Concentrations of Antibiotics in Cerebral Abscess Fluid and Cerebrospinal Fluid. In: Schiefer, W., Klinger, M., Brock, M. (eds) Brain Abscess and Meningitis. Advances in Neurosurgery, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67943-8_17
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DOI: https://doi.org/10.1007/978-3-642-67943-8_17
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