Newer Antibiotics for Brain Abscess Treatment Investigated in Animal Experiments
The treatment of the brain abscess is the treatment of a dynamic process of inflammation. The antibiotics employed here exert their effect on an ever-changing blood-brain-barrier, whose penetrability is constantly changing. In the initial stages of the intracerebral inflammation, the penetrability of this barrier is great and one may expect high antibiotic concentrations in the vicinity of the phlegmonous process. As the capsule formation progresses, the amount of edema decreases, the penetrability of the blood-brain-barrier sinks and the concentration of the antibiotic near the abscess is also lower.
KeywordsAgar Dexamethasone Meningitis Chloramphenicol Staphylococcus
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