Impaired Cardiac Performance in Rats with Long-Term Spontaneous Hypertension

  • J. Pfeffer
  • M. Pfeffer
  • P. Fletcher
  • E. Braunwald
Conference paper
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)


Cardiac performance was assessed during the progression from moderate to severe left ventricular hypertrophy in ether-anesthetized 6- and 18-month-old female spontaneously hypertensive rats (SHR), in 18-month-old male SHR, and in sex- and age-matched normotensive rats (NORM). Peak pumping ability during volume loading, maximum pressure generation during an aortic occlusion, and passive pressure-volume relationships were determined. Ejection phase indexes of young female SHR were comparable to those of age-matched NORM, i.e., both groups ejected the same peak stroke volumes from similar end-diastolic volumes, so that their indexes of ejection fraction were identical. However, a reduced peak stroke volume was ejected from a normal end-diastolic volume in old female SHR and from a significantly larger end-diastolic volume in old male SHR, so that ejection fraction indexes were moderately and substantially reduced, respectively. Maximum pressure developed during an aortic occlusion was always significantly greater in SHR. Despite elevated systemic arterial blood pressures and moderate cardiac hypertrophy, young female SHR ejected a normal stroke volume from a normal end-diastolic volume. Even though the severity of hypertension did not progress with age, cardiac mass increased markedly in old female and male SHR, and yet systolic function decreased. Therefore, hypertrophic growth of the left ventricle of the SHR is associated with both a compensated and a depressed phase of cardiac performance.


Cardiac Mass Aortic Occlusion Aortic Blood Flow Ventricular Weight Impaired Cardiac Performance 
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  1. 1.
    Pfeffer MA, Pfeffer JM, Fröhlich ED (1976) Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat. Circ Res 38: 423–429PubMedGoogle Scholar
  2. 2.
    Pfeffer MA, Fröhlich ED (1973) Hemodynamic and myocardial function in young and old normo tensive and spontaneously hypertensive rats. Circ Res [Suppl I] 32 /33: 28–38Google Scholar
  3. 3.
    Pfeffer JM, Pfeffer MA, Fishbein MC, Fröhlich ED (1979) Cardiac function and morphology with aging in the spontaneously hypertensive rat. Am J Physiol: H461–H468Google Scholar
  4. 4.
    Pfeffer MA, Fröhlich ED (1972) Electromagnetic flowmetry in anesthetized rats. J Appl Physiol 33: 137–140PubMedGoogle Scholar
  5. 5.
    Pfeffer MA, Pfeffer JM, Fishbein MC, Fletcher PJ, Spadaro J, Kloner RA, Braunwald EB (1979) Myocardial infarct size and ventricular function in rats. Circ Res 44: 503–512PubMedGoogle Scholar
  6. 6.
    Snedecor GW, Cochran WG (1967) Statistical methods, 6th edn Iowa State University Press, Ames, IowaGoogle Scholar
  7. 7.
    Grossman W, Jones D, McLaurin L (1975) Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 56: 56–64PubMedCrossRefGoogle Scholar
  8. 8.
    Averiii DB, Ferrario CM, Tarazi RC, Sen S, Bajbus R (1976) Cardiac performance in rats with renal hypertension. Circ Res 38: 280–288Google Scholar
  9. 9.
    Hallbäck M, Isaksson O, Noresson E (1975) Consequences of myocardial structural adaptation of left ventricular compliance and the Frank-Starling relationship in spontaneously hypertensive rats. Acta Physiol Scand 94: 259–270PubMedCrossRefGoogle Scholar
  10. 10.
    Strauer BE (1978) The heart in hypertension. I. Left ventricular function at rest and during exercise. Z Kardiol 67: 375–383PubMedGoogle Scholar
  11. 11.
    Karliner JS, Williams D, Gorwit J, Crawford MH, O’Rourke RA (1977) Left ventricular performance in patients with left ventricular hypertrophy caused by systemic arterial hypertension. Br Heart J 39: 1239–1245CrossRefGoogle Scholar
  12. 12.
    Savage DD, Drayer JIM, Henry WL, Mathews EC, Ware JH, Gardin JM, Cohen ER, Epstein SE, Laragh JH (1979) Echocardiographic assessment of cardiac anatomy and function in hypertensive subjects. Circulation 59: 623–632PubMedGoogle Scholar
  13. 13.
    ToshimaH, Koga Y, Toshioka H, Akiyoshi T, Kimura N (1975) Echocardiography classification of hypertensive heart disease. A correlative study with clinical features. Jpn Heart J 16: 377–393Google Scholar
  14. 14.
    Dunn FG, Chandraratna P, deCarvalho JGR, Basta LL, Fröhlich ED (1977) Pathophysiologic assessment of hypertensive heart disease with echocardiography. Am J Cardiol 39: 789–795PubMedCrossRefGoogle Scholar
  15. 15.
    Schlant RC, Feiner JM, Heymsfield SB, Gilbert CA, Shulman NB, Tuttle EP, Blumenstein BA (1977) Echocardiographic studies of left ventricular anatomy and function in essential hypertension. Cardio vase Med 2: 477–491Google Scholar
  16. 16.
    Noble MIM, Trenchard A, Guz A (1966) Left ventricular ejection in conscious dogs: I. Measurement and significance of the maximum acceleration of blood from the left ventricle. Circ Res 19: 139–147Google Scholar
  17. 17.
    Nutter DO, Noble RJ, Hurst VM (1971) Peak aortic flow and acceleration as indices of ventricular performance in the dog. J Lab Clin Med 77: 307–318PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • J. Pfeffer
  • M. Pfeffer
  • P. Fletcher
  • E. Braunwald

There are no affiliations available

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