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Cross Bridge Mechanics in the Heart Muscle of Spontaneously Hypertensive Rats

  • A. Schneider
  • B. E. Strauer
Conference paper
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)

Abstract

Pressure load of the heart in essential hypertension results in left ventricular hypertrophy with contractility of the ventricle in situ being approximately normal (see session C, Strauer). Spntaneously hypertensive rats (SHR, strain Okamoto) represent a widely accepted animal model for essential hypertension. In these rats ventricular function in situ is normal as in human hypertension. Isolated left ventricular papillary muscles show a decrease of isotonic contraction velocity, whereas maximum isometric tension development and contractility parameters not related to velocity are approximately normal or even increased in compensated stages of hypertension of SHR [1 (see session A, Bürger and Strauer)].

Keywords

Papillary Muscle Contractile Protein Cross Bridge Contractility Parameter Myosin Cross Bridge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • A. Schneider
  • B. E. Strauer

There are no affiliations available

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