Skip to main content
SpringerLink
Log in
Book cover

The Heart in Hypertension pp 143–151Cite as

Cross Bridge Mechanics in the Heart Muscle of Spontaneously Hypertensive Rats

  • Conference paper

Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

Abstract

Pressure load of the heart in essential hypertension results in left ventricular hypertrophy with contractility of the ventricle in situ being approximately normal (see session C, Strauer). Spntaneously hypertensive rats (SHR, strain Okamoto) represent a widely accepted animal model for essential hypertension. In these rats ventricular function in situ is normal as in human hypertension. Isolated left ventricular papillary muscles show a decrease of isotonic contraction velocity, whereas maximum isometric tension development and contractility parameters not related to velocity are approximately normal or even increased in compensated stages of hypertension of SHR [1 (see session A, Bürger and Strauer)].

Supported by the Deutsche Forschungsgemeinschaft

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bürger S, Meinardus A, Strauer BE (1978) Hypertrophiegrad and Dynamik des linken Ventrikels bei der spontanen essentiellen Hypertonie der Ratte Klin Wochenschr 56: 207–209

    Google Scholar 

  2. Coote JH, Sato Y (1977) Reflex regulation of sympathetic activity in the spontaneously hypertensive rat. Circ Res 40: 571–577

    PubMed  CAS  Google Scholar 

  3. Ebashi S, Endo M (1968) Calcium ion and muscle contraction. Prog Biophys Mol Biol 18: 123–183

    Article  PubMed  CAS  Google Scholar 

  4. Froehlich JP, Lakatta EG, Beard E, Spurgeon HA, Weisfeldt ML, Gerstenblith G (1978) Studies of sarcoplasmic reticulum function and contraction duration in young and aged rat myocardium. J Mol Cell Cardiol 10: 427–438

    Article  PubMed  CAS  Google Scholar 

  5. Huxley AF, Simmons RM (1971) Proposed mechanism of force generation in striated muscle. Nature 233: 533–538

    Article  PubMed  CAS  Google Scholar 

  6. Iriuchijma J (1973) Sympathetic discharge rate in spontaneously hypertensive rats. Jpn Heart J 14: 350–356

    Article  Google Scholar 

  7. Judy WV, Watanabe AM, Henry DP, Besch HR, Murphy WR, Hockel GM (1976) Sympathetic nerve activity: Role in regulation of blood pressure in the spontaneously hypertensive rat. Circ Res Suppl II 38: 21–29

    Google Scholar 

  8. Katz AM (1972) The force-velocity curve. Cardiol 57: 2–10

    Article  CAS  Google Scholar 

  9. Limas CJ, Cohn JN (1977) Defective calcium transport by cardiac sarcoplasmic reticulum in spontaneous hypertensive rats. Circ Res Suppl I 40: 62–69

    Google Scholar 

  10. Okamoto K, Aoki K (1963) Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27: 282–293

    Article  PubMed  CAS  Google Scholar 

  11. Okamoto K, Nosaka S, Yamori Y, Matsumoto M (1967) Participation of neural factors in the pathogenesis of hypertension in the spontaneously hypertensive rat. Jpn Heart J 8: 168–180

    Article  PubMed  CAS  Google Scholar 

  12. Penpargkul S, Bhan AK, Scheurer J (1976) Studies of subcellular control factors in hearts of uremic rats. J Lab Clin Med 88: 563–570

    PubMed  CAS  Google Scholar 

  13. Schädler M, Steiger GJ, Rüegg JC (1971) Mechanical activation and isometric oscillation in insect fibrillar muscle. Pfluegers Arch 330: 217–229

    Article  Google Scholar 

  14. Steiger GJ (1973) Mechanische Experimente an Herzmuskelpräparaten. Habilitationsschrift, University of Bochum

    Google Scholar 

  15. Steiger GJ (1977) Tension transients in extracted rabbit heart muscle preparations. J Mol Cell Cardiol 9: 671–685

    Article  PubMed  CAS  Google Scholar 

  16. Thorson J, White DCS (1969) Distributed representations for actin-myosin interaction in the oscillatory contraction of muscle. Biophys J 9: 360–390

    Article  PubMed  CAS  Google Scholar 

  17. Tritthart H, Kaufmann R, Volkmer HP, Bayer R, Krause H (1973) Ca-movement controlling myocardial contractility. Pfluegers Arch 338: 207–231

    Article  CAS  Google Scholar 

  18. Yamori Y (1976) Neural and non-neural mechanisms in spontaneous hypertension. Clin Sei Mol Med 51: 431s–434s

    Google Scholar 

Download references

Authors
  1. A. Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. E. Strauer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik I, Universität München Klinikum Großhadern, Marchioninistraße 15, D-8000, München 70, Germany

    Bodo Eckehard Strauer

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schneider, A., Strauer, B.E. (1981). Cross Bridge Mechanics in the Heart Muscle of Spontaneously Hypertensive Rats. In: Strauer, B.E. (eds) The Heart in Hypertension. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67922-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67922-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10496-4

  • Online ISBN: 978-3-642-67922-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation