Advertisement

Invasion of Vascular Endothelial Cell Monolayers and Underlying Matrix by Metastatic Human Cancer Cells

  • R. H. Kramer
  • G. L. Nicolson

Abstract

The survival of blood-borne malignant cells depends on their abilities to successfully implant or attach to vascular endothelial cells, invade or extravasate the endothelium and underlying matrix or basement membrane and establish a microenvironment for sub-sequent vascularization and growth (Fidler et al. 1978; Fidler and Nicolson 1980). Once malignant cells have attached to vascular endothelial cells they can escape the circulatory environment by one or more possible mechanisms: breakage of endothelial cell intercellular junctional complexes (Sindelar et al. 1975; Carr et al. 1976), enzymatic or cytotoxic destruction of endothelial cells (Fonck-Cussac et al. 1969; Vlaeminck et al. 1972), penetration of endothelial cell cytoplasm by tumor cell pseudopodia (Locker et al. 1970), or endothelial cell rupture at the site of arrest due to expansive tumor growth (Carr et al. 1976).

Keywords

Human Tumor Cell Line Endothelial Cell Monolayer Adjacent Endothelial Cell Underlying Matrix Endothelial Cell Retraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abercrombie M (1975) In: Walborg EF Jr (ed) Cellular membranes and tumor cell behaviour. Williams and Wilkins, Baltimore, p 21Google Scholar
  2. Abercrombie M, Heaysman JEM (1953) Exp Cel Res 5: 111–131CrossRefGoogle Scholar
  3. Birdwell CR, Godpodarowicz D, Nicolson GL (1978) Proc Natl Acad Sci USA 75: 3273–3277PubMedCrossRefGoogle Scholar
  4. Carr I, McGinty F, Norris P (1976) J Pathol 118: 91–99PubMedCrossRefGoogle Scholar
  5. Carter SB (1965) Nature 208: 1183–1187PubMedCrossRefGoogle Scholar
  6. Cohen AL, Marlow DP, Garner GE (1968) J Microsc 7: 331–333Google Scholar
  7. Dingemans KP (1973) J Natl Cancer Inst 51: 1883–1897PubMedGoogle Scholar
  8. Dingemans KP, Roos E, Van Den Bergh Weerman MA, Van De Pavert IV (1978) J Natl Cancer Inst 60: 583–598PubMedGoogle Scholar
  9. Dulbecco R (1970) Nature 227: 802–806PubMedCrossRefGoogle Scholar
  10. Fasske E, Fetting R, Ruhland D, Schubert T, Themann H (1975) Z Krebsforsch 84: 257–269CrossRefGoogle Scholar
  11. Fidler IJ (1978) Cancer Res 38: 2651–2660PubMedGoogle Scholar
  12. Fidler I J, Nicolson GL (1980) Cancer Biol Rev, 2: in pressGoogle Scholar
  13. Fidler IJ, Gersten DM, Hart IR (1978) Adv Cancer Res 28: 149–250PubMedCrossRefGoogle Scholar
  14. Fonck-Cussac Y, Delage J, Petit J (1969) Poumon Coeur 25: 232–234Google Scholar
  15. Gospodarowicz D (1975) J Biol Chem 250: 2515–2520PubMedGoogle Scholar
  16. Kramer RH, Nicolson GL (1979a) Proc Natl Acad Sci USA 76: 5704–5708PubMedCrossRefGoogle Scholar
  17. Kramer RH, Nicolson GL (1979b) J Supramol Struct [Suppl 3]: 181Google Scholar
  18. Kramer RH, Gonzalez R, Nicolson GL (1980) Int J Cancer, in pressGoogle Scholar
  19. Kramer RH, Vogel KG, Nicolson GL (1980) J Cell Biol 85:CS–757aGoogle Scholar
  20. Locker J, Goldblatt PJ, Leighton J (1970) Cancer Res 30: 1632–1644PubMedGoogle Scholar
  21. Ludatsher RM, Luse SA, Suntzeff V (1967) Cancer Res 27: 1939–1952Google Scholar
  22. Marchesi VT, Florey HW (1960) Q J Exp Physiol 45: 343–348Google Scholar
  23. Poste G, Doll J, Hart IR, Fidler IJ (1980) Cancer Res 40: 1636–1644PubMedGoogle Scholar
  24. Rasheed S, Nelson-Rees WA, Toth EM, Arnstein P, Gardner MB (1974) Cancer 33: 1027–1033PubMedCrossRefGoogle Scholar
  25. Sage H, Bornstein P (1979) J Cell Biol 83: 97aGoogle Scholar
  26. Sindelar WF, Tralka TS, Ketcham AS (1975) J Surg Res 18: 137–161PubMedCrossRefGoogle Scholar
  27. Vlaeminck MN, Adenis L, Mouton Y, Demaille A (1972) Int J Cancer 10: 619–631PubMedCrossRefGoogle Scholar
  28. Wood S Jr (1958) Arch Pathol 66: 550–568Google Scholar
  29. Wood S Jr (1964) Bull Schweiz Akad Med Wiss 20: 92–121Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • R. H. Kramer
    • 1
  • G. L. Nicolson
    • 1
    • 2
  1. 1.Department of Developmental and Cell BiologyUniversity of CaliforniaIrvineUSA
  2. 2.Department of Tumor BiologyUniversity of Texas System Cancer Center, M. D. Anderson Hospital and Tumor InstituteHoustonUSA

Personalised recommendations