Invasion of Vascular Endothelial Cell Monolayers and Underlying Matrix by Metastatic Human Cancer Cells

  • R. H. Kramer
  • G. L. Nicolson


The survival of blood-borne malignant cells depends on their abilities to successfully implant or attach to vascular endothelial cells, invade or extravasate the endothelium and underlying matrix or basement membrane and establish a microenvironment for sub-sequent vascularization and growth (Fidler et al. 1978; Fidler and Nicolson 1980). Once malignant cells have attached to vascular endothelial cells they can escape the circulatory environment by one or more possible mechanisms: breakage of endothelial cell intercellular junctional complexes (Sindelar et al. 1975; Carr et al. 1976), enzymatic or cytotoxic destruction of endothelial cells (Fonck-Cussac et al. 1969; Vlaeminck et al. 1972), penetration of endothelial cell cytoplasm by tumor cell pseudopodia (Locker et al. 1970), or endothelial cell rupture at the site of arrest due to expansive tumor growth (Carr et al. 1976).


Human Tumor Cell Line Endothelial Cell Monolayer Adjacent Endothelial Cell Underlying Matrix Endothelial Cell Retraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • R. H. Kramer
    • 1
  • G. L. Nicolson
    • 1
    • 2
  1. 1.Department of Developmental and Cell BiologyUniversity of CaliforniaIrvineUSA
  2. 2.Department of Tumor BiologyUniversity of Texas System Cancer Center, M. D. Anderson Hospital and Tumor InstituteHoustonUSA

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