The Role of Topographical Factors in Cell Interaction and Determination of Cell Lines in Molluscan Development

  • J. A. M. van den Biggelaar
  • A. W. C. Dorresteijn
  • S. W. de Laat
  • J. G. Bluemink
Conference paper


Most organisms develop from eggs that possess some degree of cytoplasmic heterogeneity. The heterotropy of the ooplasmic constituents is used as a morphogenetic instrument as determination and differentiation of the blastomeres are influenced by the inheritance of special parts of the ooplasm. The partitioning of different regions of the ovum over the cleavage cells can only partly account for the diversification of their developmental pattern. A second important morphogenetic instrument is the interaction between cells.


Topographical Factor Cleavage Cell Shell Gland Polar Lobe Dorsoventral Polarity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson DT (1973) Embryology and phylogeny in annelids and arthropods, International Series of Monographs in Pure and Applied Biology, Zoology Division, vol 50. Pergamon PressGoogle Scholar
  2. Berendsen W (1971) Morphologische analyse van de eerste celdeling van het ei van Lymnaea stagnalis L. Thesis, UtrechtGoogle Scholar
  3. Biggelaar JAM van den (1976) Proc Kon Ned Akad Wetensch 79: 112–126Google Scholar
  4. Biggelaar JAM van den (1977) J Morphol 154: 157–186PubMedCrossRefGoogle Scholar
  5. Biggelaar JAM van den, Guerrier P (1979) Dev Biol 68: 462–471PubMedCrossRefGoogle Scholar
  6. Cather JN (1967) J Exp Zool 166: 205–224PubMedCrossRefGoogle Scholar
  7. Cather JN, Verdonk NH (1974) J Embryol Exp Morphol 31: 415–422PubMedGoogle Scholar
  8. Clement AC (1952) J Exp Zool 121: 593–626CrossRefGoogle Scholar
  9. Clement AC (1962) J Exp Zool 149: 193–216CrossRefGoogle Scholar
  10. Clement AC (1968) Dev Biol 17: 165–186PubMedCrossRefGoogle Scholar
  11. Crampton HE (1896) Arch Entwicklungsmech Org 3: 1–19CrossRefGoogle Scholar
  12. Davidson EH (1976) Gene activity in early development, 2nd ed. Acad. Press, New YorkGoogle Scholar
  13. Dohmen MR, Mey JCA van der (1977) Dev Biol 61: 104–113PubMedCrossRefGoogle Scholar
  14. Dohmen MR, Verdonk NH (1979 a) J Embryol Exp Morphol 31: 423–433Google Scholar
  15. Dohmen MR, Verdonk NH ( 1979 b) In: Subtelny, S, Königsberg, IR (eds) Determinants of spatial organization. Acad Press, NY, pp 3–27Google Scholar
  16. Dongen CAM van (1976) Proc Kon Ned Akad Wetensch 79: 454–465Google Scholar
  17. Dongen CAM van, Geilenkirchen WLM (1975) Proc Kon Ned Akad Wetensch 79: 245–266Google Scholar
  18. Geilenkirchen WLM, Verdonk NH, Timmermans LPM (1979) J Embryol Exp Morphol 23: 237–243Google Scholar
  19. Grimmelikhuijzen CJP, Lepault J, McDowall AW, Laat SW de, Tertoolen LGJ, Weyer CJ (1980) In: Tardent P, Tardent R (eds) Developmental and cellular biology of coelenterates. Elsevier/ North-Holland Biomedical Press, pp 453–458Google Scholar
  20. Guerrier P (1970) J Embryol Exp Morphol 23: 611–637PubMedGoogle Scholar
  21. Guerrier P, Biggelaar JAM van den, Dongen CAM van, Verdonk NH (1977) Dev Biol 63: 233–242CrossRefGoogle Scholar
  22. Laat SW de, Tertoolen LGJ, Dorresteijn AWC, Biggelaar JAM van den (1980) Nature 287: 546–548PubMedCrossRefGoogle Scholar
  23. Loewenstein WR (1968 a) Dev Biol 19: Suppl 2, 151–183Google Scholar
  24. Loewenstein WR (1968 b) Biol Med (Paris) 11: 260–272Google Scholar
  25. Loewenstein WR (1979) Biochim Biophys Acta 560: 1–65PubMedGoogle Scholar
  26. Morrill JB (1963) Exp Cell Res 31: 490–498CrossRefGoogle Scholar
  27. Morrill JB, Blair CA, Larsen WJ (1973) J Exp Zool 183: 47–56CrossRefGoogle Scholar
  28. Rattenbury JC, Berg WE (1954) J Morphol 95: 393–414CrossRefGoogle Scholar
  29. Raven ChrP (1966) Morphogenesis: The analysis of molluscan development, 2nd ed. Pergamon, OxfordGoogle Scholar
  30. Stewart WW (1978) Cell 14: 741–759PubMedCrossRefGoogle Scholar
  31. Tyler A (1930) J Exp Zool 57: 347–402CrossRefGoogle Scholar
  32. Unwin PNT, Zampighi G (1980) Nature 283: 545–549PubMedCrossRefGoogle Scholar
  33. Verdonk NH (1968) J Embryol Exp Morphol 19: 33–43PubMedGoogle Scholar
  34. Verdonk NH (1979) In: Spoel S van der, Bruggen AC van, Lever J (eds) Pathways in malacology. Bohn, Scheltema and Holkema, Utrecht, pp 25–45Google Scholar
  35. Wilson, EB (1904a) J Exp Zool 1: 1–72CrossRefGoogle Scholar
  36. Wilson EB (1904b) J Exp Zool 1: 197–268CrossRefGoogle Scholar
  37. Wilson EB (1925) The Cell in development and heredity, 3rd ed. Macmillan, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • J. A. M. van den Biggelaar
    • 1
  • A. W. C. Dorresteijn
    • 1
  • S. W. de Laat
    • 2
  • J. G. Bluemink
    • 2
  1. 1.Zoological LaboratoryUniversity of UtrechtUtrechtThe Netherlands
  2. 2.Hubrecht LaboratoryInternational Embryological InstituteUtrechtThe Netherlands

Personalised recommendations