Cellular Transformation by Polyoma Virus

  • U. Novak
  • B. E. Griffin
Conference paper


Polyoma is a virus carried by mice. In its natural host, only under exceptional circumstances is it oncogenic. The exceptions are revealed when large doses of the virus are injected into the animal, or when it is immunodeficient. For example, Allison et al. (1974) found that athymic nude (nu/nu) mice were highly susceptible to polyoma virus and a wide variety of tumours, including carcinomas of the skin follicles, salivary glands, kidneys and renal pelvis, and osteosarcomas, were produced in these animals within four weeks after the virus had been injected. Polyoma virus also produces tumours in a variety of other rodents under less exceptional circumstances.


Hydrophobic Region Vesicular Stomatitis Virus Wild Type Virus Cellular Transformation Carboxy Terminus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allison AC, Monga TN, Hammond V (1974) Nature 252: 746–747PubMedCrossRefGoogle Scholar
  2. Bendig MM, Thomas T, Folk WR (1980) J Virol 33: 1215–1220PubMedGoogle Scholar
  3. Birg F, Dulbecco R, Fried M, Kamen R (1979) J Virol 29: 633–648PubMedGoogle Scholar
  4. Eckhart W, Hutchinson MA, Hunter T (1979) Cell 18: 925–933PubMedCrossRefGoogle Scholar
  5. Frearson PM, Crawford LV (1972) J Gen Virol 14: 141–155PubMedCrossRefGoogle Scholar
  6. Graham FL, Van der Eb (1973) Virology 54: 536–539PubMedCrossRefGoogle Scholar
  7. Griffin BE (1980a) In: Tooze J (ed) DNA tumor viruses, Cold Spring Harbor Lab., p 61Google Scholar
  8. Griffin BE (1980 b) In Seeberg E, Kleppe K (eds) Chromosome damage and repair. Plenum Press, in pressGoogle Scholar
  9. Griffin BE, Maddock C (1979) J Virol 31: 645–656PubMedGoogle Scholar
  10. Griffin BE, Dilworth SM, Novak U (1980 a) Polyoma virus: some considerations on its transforming genes. Proc R Soc Lond [Biol] 210:465–476CrossRefGoogle Scholar
  11. Griffin BE, Ito Y, Novak U, Spurr N, Dilworth SM, Smolar N, Pollack R, Smith K, Rifkin D (1980 b) Cold Spring Harbor Symp Quant Biol 44:271–283PubMedGoogle Scholar
  12. Hattori J, Carmichael GG, Benjamin TL (1979) Cell 16: 505–513PubMedCrossRefGoogle Scholar
  13. Israel MA, Vanderryn DF, Meitzer ML, Martin MA (1980) J Biol Chem. 255: 3798–3805PubMedGoogle Scholar
  14. Ito Y (1979) Virology 98: 261–266PubMedCrossRefGoogle Scholar
  15. Ito Y, Brocklehurst JR, Dulbecco R (1977) Proc Natl Acad Sci USA 74: 4666–4670PubMedCrossRefGoogle Scholar
  16. Ito Y, Spurr N, Griffin BE (1980) J Virol 35: 219–242PubMedGoogle Scholar
  17. Kamen R, Favaloro J, Parker J, Treisman R, Lania L, Fried M, Mellor A (1980). Cold Spring Harbor Symp Quant Biol 44: 63–75PubMedGoogle Scholar
  18. Klee CB, Crouch TH, Richmond PG (1980) In: Snell EE, Boyer PD, meister A, Richardson CC. Ann Rev Biochem 49:489Google Scholar
  19. Lania L, Gandini-Attardi D, Griffiths M, Cooke B, deCicco D, Fried M (1980) Virology 101: 217–232PubMedCrossRefGoogle Scholar
  20. Magnusson G, Berg P (1979) J Virol 32: 523–529PubMedGoogle Scholar
  21. Miller LK, Fried M (1976) J Virol 18: 824–832PubMedGoogle Scholar
  22. Novak U, Dilworth SM, Griffin BE (1980) Proc Natl Acid Sci USA 77: 3278–3282CrossRefGoogle Scholar
  23. Rose JK, Welch WJ, Sefton BM, Esch FS, Ling NC (1980) Proc Natl Acad Sci USA 77: 3884–3888PubMedCrossRefGoogle Scholar
  24. Schaffhausen BS, Benjamin TL (1979) Cell 18: 935PubMedCrossRefGoogle Scholar
  25. Smart JE, Ito Y (1979) Cell 15: 1427–1437CrossRefGoogle Scholar
  26. Smith AE, Smith R, Griffin BE, Fried M (1979) Cell 18: 915–924PubMedCrossRefGoogle Scholar
  27. Soeda E, Griffin BE (1978) Nature 276: 294–298PubMedCrossRefGoogle Scholar
  28. Soeda E, Arrand JR, Griffin BE (1979a) Cell 17:357–370CrossRefGoogle Scholar
  29. Soeda E, Arrand JR, Smolar N, Walsh JE, Griffin BE (1980) Nature 283: 445–453PubMedCrossRefGoogle Scholar
  30. Tegtmeyer P (1980) In: Tooze J (ed) DNA tumor viruses, Cold Spring Harbor Lab., p 279Google Scholar
  31. Topp WC, Lane D, Pollack R (1980) In: Tooze J (ed) DNA tumor viruses, Cold Spring Harbor Lab, p 205Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • U. Novak
  • B. E. Griffin
    • 1
  1. 1.Imperial Cancer Research FundLondonEngland

Personalised recommendations