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Cellular Transformation by Polyoma Virus

  • U. Novak
  • B. E. Griffin
Conference paper

Abstract

Polyoma is a virus carried by mice. In its natural host, only under exceptional circumstances is it oncogenic. The exceptions are revealed when large doses of the virus are injected into the animal, or when it is immunodeficient. For example, Allison et al. (1974) found that athymic nude (nu/nu) mice were highly susceptible to polyoma virus and a wide variety of tumours, including carcinomas of the skin follicles, salivary glands, kidneys and renal pelvis, and osteosarcomas, were produced in these animals within four weeks after the virus had been injected. Polyoma virus also produces tumours in a variety of other rodents under less exceptional circumstances.

Keywords

Hydrophobic Region Vesicular Stomatitis Virus Wild Type Virus Cellular Transformation Carboxy Terminus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • U. Novak
  • B. E. Griffin
    • 1
  1. 1.Imperial Cancer Research FundLondonEngland

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