Microtubule Polarity and Interaction in Mitotic Spindle Function

  • J. R. McIntosh

Abstract

Biological machines that use a scalar quantity like chemical potential to generate a vector quantity like force for cell movement are necessarily both anisotropic and polar. These asymmetries are generally provided by fibrous proteins that are the principal building blocks of cellular motors. There is a marked conservatism in the components of the machines thus far identified in eukaryotic cells: most of them include proteins similar to those either of muscle or of flagella. Wherever the machines are understood in any detail, the protein components are known to interact in geometrically specific ways during the transduction of chemical energy into work. We presume, therefore, that a knowledge of molecular polarity and interaction will be important for the understanding of each mechanochemical device.

Keywords

Burning Migration Anisotropy Mold Nism 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • J. R. McIntosh
    • 1
  1. 1.Dept. of Molecular, Cellular, and Developmental BiologyUniversity of ColoradoBoulderUSA

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