The Polymerization of Actin
To my mind, the union of the independently successful disciplines of morphology, ultra- structure and biochemistry into a highly productive cell biochemistry is the most exciting development in cell biology since the previous International Congress. We have now begun the serious study of the chemical and enzymatic compositions of structural elements and the influence of organization on biological function. Moreover, I believe there is now wide acceptance of the view that to understand the molecular mechanisms that regulate complex cellular events it is necessary to purify the individual proteins and study their properties alone and in systems reconstituted under carefully controlled conditions. It is this that I call cell biochemistry: the application of the experimental approaches developed by the biochemist to the structures and activities observed by the cell biologist.
KeywordsHydrolysis Dition Librium Cytochalasin Erythro
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- Brenner SL, Korn ED (1979 a) J Biol Chem 254: 8620–8627Google Scholar
- Brown SS, Spudich JA (1979) J Biol Chem 83: 657–662Google Scholar
- Gordon DJ, Boyer JJ, Korn ED (1977) J Biol Chem 252: 6501–6509Google Scholar
- Oosawa F, Asakura S (1975) In: Thermodynamics of the polymerization of proteins. Academic Press, New YorkGoogle Scholar
- Yang Y-Z, Korn ED, Eisenberg E (1979 a) J Biol Chem 254: 2084–2088Google Scholar
- Yang Y-Z, Korn ED, Eisenberg E (1979 b) J Biol Chem 254: 7137–7140Google Scholar