The Polymerization of Actin

  • E. D. Korn
Conference paper

Abstract

To my mind, the union of the independently successful disciplines of morphology, ultra- structure and biochemistry into a highly productive cell biochemistry is the most exciting development in cell biology since the previous International Congress. We have now begun the serious study of the chemical and enzymatic compositions of structural elements and the influence of organization on biological function. Moreover, I believe there is now wide acceptance of the view that to understand the molecular mechanisms that regulate complex cellular events it is necessary to purify the individual proteins and study their properties alone and in systems reconstituted under carefully controlled conditions. It is this that I call cell biochemistry: the application of the experimental approaches developed by the biochemist to the structures and activities observed by the cell biologist.

Keywords

Hydrolysis Dition Librium Cytochalasin Erythro 

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References

  1. Blikstad I, Sundkvist I, Lindberg U (1980) Eur J Biochem 105: 425–433PubMedCrossRefGoogle Scholar
  2. Brenner SL, Korn ED (1979 a) J Biol Chem 254: 8620–8627Google Scholar
  3. Brenner SL, Korn ED (1979b) J Biol Chem 254: 9982–9985PubMedGoogle Scholar
  4. Brenner SL, Korn ED (1980a) J Biol Chem 255: 841–844PubMedGoogle Scholar
  5. Brenner SL, Korn ED (1980b) J Biol Chem 255: 1670–1676PubMedGoogle Scholar
  6. Brown SS, Spudich JA (1979) J Biol Chem 83: 657–662Google Scholar
  7. Carlsson L, Nystrom L-E, Sundkvist I, Markey F, Lindburg U (1977) J Mol Biol 115: 465–483PubMedCrossRefGoogle Scholar
  8. Ferri A, Magri E, Grazi E (1979) Biochem J 183: 475–476PubMedGoogle Scholar
  9. Flanagan MD, Lin S (1980) J Biol Chem 255: 835–838PubMedGoogle Scholar
  10. Gordon DJ, Boyer JJ, Korn ED (1977) J Biol Chem 252: 6501–6509Google Scholar
  11. Harris HE, Weeds AG (1978) FEBS Lett 90: 84–88PubMedCrossRefGoogle Scholar
  12. Hartwig JH, Stossel TP (1975) J Biol Chem 250: 5696–5705PubMedGoogle Scholar
  13. Hartwig JH, Stossel TP (1979) J Mol Biol 134: 539–553PubMedCrossRefGoogle Scholar
  14. Hasegawa T, Takahashi S, Hayashi H, Hatano S (1980) Biochemistry 19: 2677–2683PubMedCrossRefGoogle Scholar
  15. Kane RE (1976) J Cell Biol 71: 704–714PubMedCrossRefGoogle Scholar
  16. Knight P, Offer G (1978) Biochem J 175: 1023–1032PubMedGoogle Scholar
  17. MacLean-Fletcher S, Pollard TD (1980) Cell 20: 329–341PubMedCrossRefGoogle Scholar
  18. Markey F, Lindberg U, Eriksson L (1978) FEBS Lett 88: 75–79PubMedCrossRefGoogle Scholar
  19. Maruta H, Korn ED (1977) J Biol Chem 252: 399–402PubMedGoogle Scholar
  20. Mockrin SC, Korn ED (1980) Biochemistry 19: 5359–5362PubMedCrossRefGoogle Scholar
  21. Neidl C, Engel J (1979) Eur J Biochem 101: 163–169PubMedCrossRefGoogle Scholar
  22. Oosawa F, Asakura S (1975) In: Thermodynamics of the polymerization of proteins. Academic Press, New YorkGoogle Scholar
  23. Reichstein E, Korn ED (1979) J Biol Chem 254: 6174–6179PubMedGoogle Scholar
  24. Stendahl OI, Stossel TP (1980) Biochem Biophys Res Commun 92: 675–681PubMedCrossRefGoogle Scholar
  25. Tilney LG (1975) J Cell Biol 64: 289 - 310PubMedCrossRefGoogle Scholar
  26. Vandekerckhove J, Weber K (1979) Eur J Biochem 90: 451–462CrossRefGoogle Scholar
  27. Wang K, Singer SJ (1977) Proc Natl Acad Sci USA 74: 2021–2025PubMedCrossRefGoogle Scholar
  28. Wegner A (1976) J Mol Biol 108: 139–150PubMedCrossRefGoogle Scholar
  29. Yang, Y-Z, Gordon DJ, Korn ED, Eisenberg E (1977) J Biol Chem 252: 3374–3378PubMedGoogle Scholar
  30. Yang Y-Z, Korn ED, Eisenberg E (1979 a) J Biol Chem 254: 2084–2088Google Scholar
  31. Yang Y-Z, Korn ED, Eisenberg E (1979 b) J Biol Chem 254: 7137–7140Google Scholar
  32. Yin HL, Stossel TP (1979) Nature 281: 583–586PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • E. D. Korn
    • 1
  1. 1.Laboratory of Cell Biology, National Heart, Lung, and Blood InstituteNational Institutes of HealthBethesdaUSA

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