Effects of Vagotomy on the Catecholamine-Containing Cells in the Gastric Mucosa of the Rat: an Electron Microscopic Study
It is well known that gastric function is the result of harmonic interplay between the parasympathetic-sympathetic systems, and gastrointestinal hormones. The role of the parasympathetic system has been extensively studied. For example, it is understood that the beneficial results of vagotomy on gastric hypersecretion and peptic ulcer disease are due to an acetylcholine deficit. On the other hand, it has been shown that serotonin participates in a vagal inhibitory pathway to the stomach (1) and there is evidence for a vagal inhibitory component of gastrin release (2). It is known that there exist in the stomach wall endocrine cells containing biogenic amines. Since vagotomy may cause either permanent or temporary changes in the morphology and/or population of epithelial cells in the gastric mucosa, we studied the effects of vagotomy on a distinct cell population, namely, the entero-chromaffinng like (ECL) cells in the fundic mucosa of the rat.
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