Advertisement

Impulsübertragung an der motorischen Endplatte und Möglichkeiten ihrer Beeinflussung

  • Ch. Stumpf
Part of the Klinische Anästhesiologie und Intensivtherapie book series (KAI, volume 22)

Zusammenfassung

Die neuromuskuläre Erregungsübertragung hat, wie Abb. 1 zeigt, sowohl elektrophysiologische als auch biochemische Aspekte; sie kann darüber hinaus auch pharmakologisch beeinflußt werden.

Verwendete Abkürzungen

ACh

Acetylcholin

cAMP

cyclisches Adenosinmonophosphat (3′,5′-cAMP)

ATP

Adenosintriphosphat

5′-AMP

5′fAdenosinmonophosphat

CoA

Coenzym A

AcCoA

Acetyl-Coenzym A

ChE

Cholinesterase

AChE

Acetylcholinesterase

AChE

Acetylcholinesterase

acChE

acetylierte Cholinesterase

Anti-ChE

Anticholinesterasen (Cholinesterasehemmkörper)

ChAc

Cholinacetyltransferase

dTC

(+)-Tubocurarinhydrochlorid

C 10

Decamethonium

TEA

Tetraäthylammonium (-bromid)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    ADAMS, P. R.: Drug blockade of open end-plate channels. J. Physiol. 260, 531 (1976)PubMedGoogle Scholar
  2. 2.
    ADAMS, P. R., SAKMANN, B.: Decamethonium both opens and blocks endplate channels. Proc. nat. Acad. Sci. USA 75, 2994 (1978)PubMedCrossRefGoogle Scholar
  3. 3.
    Albuquerque, E. X., Eldefrawi, A. T., Elderfrawi, M. E., Mansour, N. A., Tsai, M.-C: Amantadine: Neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor. Science 199, 788 (1978)PubMedCrossRefGoogle Scholar
  4. 4.
    BENOIT, P. R., MAMBRINI, J.: Modification of transmitter release by ions which prolong the presynaptic action potential. J. Physiol. 210, 681 (1970)PubMedGoogle Scholar
  5. 5.
    BOWMAN, W. C., NOTT, M. W.: Actions of sympathomimetic amines and their antagonists on skeletal muscle. Pharmacol. Rev. 21, 27 (1969)PubMedGoogle Scholar
  6. 6.
    BOWMAN, W. C., WEBB, S. N.: Tetanic fade during partial transmission failure produced by non-depolarizing neuromuscular blocking drugs in the cat. Clin. exp. Pharmacol. Physiol. 3, 545 (1976)PubMedCrossRefGoogle Scholar
  7. 7.
    BOWMAN, W. C., HARVEY, A. L., MARSHALL, I. G.: The actions of aminopyridines on avian muscle. Naunyn-Schmiedeberg1s Arch. Pharmacol. 297, 99 (1977)CrossRefGoogle Scholar
  8. 8.
    CZECH, K., GOGOLAK, G., STUMPF, CH.: In VorbereitungGoogle Scholar
  9. 9.
    DALE, H. H., FELDBERG, W., VOGT, M.: Release of acetylcholine at voluntary motor nerve endings. J. Physiol. 86, 353 (1936)PubMedGoogle Scholar
  10. 10.
    FOLDES, F. F.: Presynaptic aspects of neuromuscular transmission and block. Anaesthesist 20, 6 (1971)PubMedGoogle Scholar
  11. 11.
    GALINDO, A.: Prejunctional effect of curare: its relative importance. J. Neurophysiol. 34, 289 (1971)PubMedGoogle Scholar
  12. 12.
    GALINDO, A.: Depolarizing neuromuscular block. J. Pharmacol. exp. Ther. 178, 339 (1971)PubMedGoogle Scholar
  13. 13.
    GILLESPIE, J. I., HUTTER, O. F.: The actions of 4-aminopyri-dine on the delayed potassium current in skeletal muscle fibers. J. Physiol. 252, 70 p (1975)Google Scholar
  14. 14.
    GINSBORG, B. L., JENKINSON, D. H.: Transmission of impulses from nerve to muscle. In: Handbuch der experimentellen Pharmakologie, vol. 42. Neuromuscular junction (ed. E. ZAIMIS), p. 229. Berlin, Heidelberg, New York: Springer 1976Google Scholar
  15. 15.
    HOBBIGER, F.: Pharmacology of anticholinesterase drugs. In: Handbuch der experimentellen Pharmakologie, vol. 42. Neuromuscular junction (ed. E. ZAIMIS), p. 487. Berlin, Heidelberg, New York: Springer 1976Google Scholar
  16. 16.
    JOHNS, A., GOLKO, D. S., LAUZON, P. A., PATON, D. M.: The potentiating effects of 4-aminopyridine on adrenergic transmission in the rabbit vas deferens. Europ. J. Pharmacol. 38, 71 (1976)CrossRefGoogle Scholar
  17. 17.
    KARIS, J. H., GISSEN, A. J.: Evaluation of new neuromuscular blocking agents. Anesthesiology 35, 149 (1971)PubMedCrossRefGoogle Scholar
  18. 18.
    KARLIN, A.: On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine. J. theor. Biol. 16, 306 (1967)PubMedCrossRefGoogle Scholar
  19. 19.
    KARLIN, A.: Chemical modification of the active site of the acetylcholine receptor. J. gen. Physiol. 54, 245 (1969)PubMedCrossRefGoogle Scholar
  20. 20.
    KARLIN, A.: The acetylcholine receptor: isolation and characterization. In: The nervous system (éd. D. B. Tower), vol. I. The basic neurosciences, p. 323. New York: Raven Press 1975Google Scholar
  21. 21.
    KATZ, B.: The release of neural transmitter substances. Liverpool: University Press 1969Google Scholar
  22. 22.
    KATZ, B., MILEDI, R.: A re-examination of curare action at the motor endplate. Proc. roy. Soc. Lond. B 203, 119 (1978)CrossRefGoogle Scholar
  23. 23.
    KOELLE, G. B.: A new general concept of the neurohumoral functions of acetylcholine and acetylcholinesterase. J. Pharm. Pharmacol. 14, 65 (1962)PubMedCrossRefGoogle Scholar
  24. 24.
    KOELLE, G. B.: Cytological distributions and physiological functions of cholinesterases. In: Handbuch der experimentellen Pharmakologie. Ergänzungswerk XV. Cholinesterases and anticholinesterase agents (ed. G. B. KOELLE), p. 187. Berlin, Heidelberg, New York: Springer 1963Google Scholar
  25. 25.
    LEANDER, S., ARNER, A., JOHANSSON, B.: Effects of 4-aminopyridine on mechanical activity and noradrenaline release in the rat portal vein in vitro. Europ. J. Pharmacol. 46, 351 (1977)CrossRefGoogle Scholar
  26. 26.
    LEE, C., KATZ, R. L.: Neuromuscular pharmacology. Brit. J. Anaesth. 52, 173 (1980)PubMedCrossRefGoogle Scholar
  27. 27.
    LEE, C., CHEN, D., NAGEL, E. L.: Neuromuscular block by antibiotics: Polymyxin B. Anesth. Analg. 56, 373 (1977)PubMedGoogle Scholar
  28. 28.
    LUNDH, H., LEANDER, S., THESLEFF, S.: Antagonism of the paralysis produced by botulinum toxin in the rat. The effects of tetraethylammonium, guanidine and 4-aminopyridine. J. neu-rol. Sci. 32, 29 (1977)CrossRefGoogle Scholar
  29. 29.
    MACINTOSH, F. C., COLLIER, B.: Neurochemistry of cholinergic terminals. In: Handbuch der experimentellen Pharmakologie, vol. 42. Neuromuscular junction (ed. E. ZAIMIS), p. 99. Berlin, Heidelberg, New York: Springer 1976Google Scholar
  30. 30.
    MANALIS, R. S.: Voltage-dependent effect of curare at the frog neuromuscular junction. Nature 267, 366 (1977)PubMedCrossRefGoogle Scholar
  31. 31.
    MILLER, R. D., DENNISSEN, P. A. F., VAN DER POL, F., AGOSTON, S., BOOIJ, L. H. D. J., CRUL, J. F.: Potentiation of neostigmine and pyridostigmine by 4-aminopyridine in the rat. J. Pharm. Pharmacol. 30, 69 9 (1978)Google Scholar
  32. 32.
    MILLER, R. D., BOOIJ, L. H. D. J., AGOSTON, S., CRUL, J. F.: 4-aminopyridine potentiates neostigmine and pyridostigmine in man. Anesthesiology 50, 416 (1979)PubMedCrossRefGoogle Scholar
  33. 33.
    MOLGO, J., LEMEIGNAN, M., LECHAT, P.: Effects of 4-aminopyridine at the frog neuromuscular junction. J. Pharmacol. exp. Ther. 203, 653 (1977)PubMedGoogle Scholar
  34. 34.
    NORMAN, J.: Neuromuscular blocking drugs (Editorial). Brit. J. Anaesth. 51, 471 (1979)PubMedCrossRefGoogle Scholar
  35. 35.
    PANELLA, A.: Action du principe actif surrénal sur la fatigue musculaire. Arch. ital. Biol. 48, 430 (1907)Google Scholar
  36. 36.
    PATON, W. D. M., WAUD, D. R.: The margin of safety of neuromuscular transmission. J. Physiol. 191, 59 (1967)PubMedGoogle Scholar
  37. 37.
    PELHATE, M., PICHON, Y.: Selective inhibition of potassium current in the giant axon of the cockroach. J. Physiol. 242, 90 P (1974)Google Scholar
  38. 38.
    PELHATE, M., HUE, B., PICHON, Y., CHANELET, J.: Action de la 4-aminopyridine sur la membrane de l1axone isole d1insecte. C. R. Acad. Sci. (Paris) 278, 2807 (1974)Google Scholar
  39. 39.
    RIKER JR., W. FAAction of acetylcholine on mammalian motor nerve terminal. J. Pharmacol, exp. Ther. 152, 397 (1966)Google Scholar
  40. 40.
    SALPETER, M. M.: Electron microscope radioautography as a quantitative tool in enzyme cytochemistry. I. The distribution of acetylcholinesterase at motor endplates of a vertebrate twitch muscle. J. Cell. Biol. 32, 379 (1967)CrossRefGoogle Scholar
  41. 41.
    SOTEROPOULOS, G. S., STANDAERT, F. G.: Neuromuscular effects of morphine and naloxone. J. Pharmacol, exp. Ther. 184, 136 (1973)Google Scholar
  42. 42.
    STANDAERT, F. G., DRETCHEN, K. L.: Cyclic nucleotides and neuromuscular transmission. Fed. Proc. 38 2183 (1979)PubMedGoogle Scholar
  43. 43.
    TASAKI, I.: Evolution of theories of nerve excitation. In: The nervous system (ed. D. B. TOWER), vol. I. The basic neurosciences, p. 177. New York: Raven Press 1975Google Scholar
  44. 44.
    VINCENT, A., NEWSOM-DAVIS, J., MARTIN, V.: Anti-acetylcho-line receptor antibodies in D-penicillamin-associated myasthenia gravis. Lancet 1978 I, 1254CrossRefGoogle Scholar
  45. 45.
    ZAIMIS, E.: The neuromuscular junction: Areas of uncertainty. In: Handbuch der experimentellen Pharmakologie, vol. 42. Neuromuscular junction (ed. E. ZAIMIS), p. 1. Berlin, Heidelberg, New York: Springer 1976.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1980

Authors and Affiliations

  • Ch. Stumpf

There are no affiliations available

Personalised recommendations