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Bau und Funktion der neuromuskulären Synapse

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Muskelrelaxanzien

Part of the book series: Klinische Anästhesiologie und Intensivtherapie ((KAI,volume 22))

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Zusammenfassung

Die neuromuskuläre Synapse ist das Funktionsglied in der Motorik, an dem Nervenimpulse auf Muskelfasern übertragen werden, also die Verbindung zwischen axonaler Endigung und Muskelzelle. Die Anzahl der von einem Motoneuron innervierten Muskelfasern, die zusammen mit ihm eine sogenannte motorische Einheit bilden, ist sehr unterschiedlich, ihre morphologischen und physiologischen Eigenschaften jedoch ähnlich. Beim M. rectus externus oculi des Menschen z. B. innerviert ein Neuron 13 Muskelfasern, während es im M. gastrocnemius bis zu 1.700 Muskelfasern innerviert.

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Literatur

  1. ADAMS, P. R., SAKMANN, B.: Decamethonium both opens and blocks endplate channels. Proc. nat. Acad. Sci. USA 75, 2994 (1978)

    Article  PubMed  CAS  Google Scholar 

  2. BARNARD, E. A.: Properties and function of the acetylcholine receptor of vertebrate skeletal muscle. In: Drug action at the molecular level (ed. G. C. ROBERTS). Baltimore: Univ. Park Press 1978

    Google Scholar 

  3. BROWN, M. C., HOLLAND, R. L., IRONTON, R.: Is the stimulus for motoneurons terminal sprouting localized? J. Physiol. (Lond.) 282, 7 (1979)

    Google Scholar 

  4. CARD, D. J.: Physiological alterations of rat extensor digi-torum longus motor nerve terminals as a result of surgical denervation. Exp. Neurol. 54, 478 (1977)

    Article  PubMed  CAS  Google Scholar 

  5. CHOKROVERTY, S., REYES, M. G., CHOKROVERTY, M., KAPLAN, R.: Effect of prednisolone on motor end-plate fine structure: a morphometric study in hamsters. Ann. Neurol. 3, 358 (1978)

    Article  PubMed  CAS  Google Scholar 

  6. CULL-CANDY, S. G., MILEDI, R., TRAUTMANN, A.: End-plate currents and acetylcholine noise at normal and myasthenic human end-plates. J. Physiol. (Lond.) 287, 247 (1979)

    CAS  Google Scholar 

  7. CURLESS, R. G.: Developmental patterns of peripheral nerve, myoneural junction and muscle: a review. Prog. Neurobiol. 9, 197 (1978)

    Article  Google Scholar 

  8. GILLIES, J. D., ALLEN, J.: The continual administration of neostigmine and the neuromuscular junction. Proc. Aust. Ass. Neurol. 13, 149 (1977)

    Google Scholar 

  9. HANIG, J. P., LAMANNA, C.: Toxicity of botulinum toxin: a stoichiometric model for the locus of its extraordinary potency and persistence at the neuromuscular junction. J. theor. Biol. 77, 107 (1979)

    Article  PubMed  CAS  Google Scholar 

  10. KATZ, B., MILEDI, R.: A re-examination of curare action at the motor endplate. Proc. roy. Soc. Lond. B 203, 119 (1979)

    Article  Google Scholar 

  11. KUFFLER, D., THOMPSON, W., JANSEN, J. K.: The elimination of synapses in multiply-innervated skeletal muscle fibres of the rat: dependence on distance between end-plates. Brain Res. 138, 353 (1978)

    Article  Google Scholar 

  12. LANDAU, E. M.: Function and structure of the ACh-receptor at the muscle end-plate. Prog. Neurobiol. 10, 253 (1979)

    Article  Google Scholar 

  13. LASKOWSKI, M. B., OLSON, W. H., DETTBARN, W. D.: Initial ultrastructural abnormalities at the motor end plate produced by a Cholinesterase inhibitor. Exp. Neurol. 57, 13 (1977)

    Article  PubMed  CAS  Google Scholar 

  14. LEE, C. Y., TSAI, M. C.: Is the contractile response to exogenous acetylcholine due to a presynaptic effect? Brit. J. Pharmacol. 57, 543 (1977)

    Google Scholar 

  15. MIYAMOTO, M. D.: The actions of cholinergic drugs on motor nerve terminals. Pharmacol. Rev. 28, 221 (1978)

    Google Scholar 

  16. O’BRIEN, R. A., ÖSTBERG, A., VRBOV’A, G.: Persistent poly-neuronal innervation on hyperinnervated skeletal muscle. J. Physiol. (Lond.) 280, 38 p (1979)

    Google Scholar 

  17. ÖSTBERG, A. J., VRBOV’A, G.: Illustration of the disappearance of polyneuronal innervation of developing skeletal muscle. J. Physiol. (Lond.) 271, 6 (1978)

    Google Scholar 

  18. RAHAMIMOFF, R., ERULKAR, S. D., LEV-TOV, A., MEIRI, H.: Intracellular and extracellular calcium ions in transmitter release at the neuromuscular synapse. Ann. N. Y. Acad. Sci. 307, 583 (1979)

    Article  Google Scholar 

  19. RICKER, K., HERTEL, G., STODIECK, S.: The influence of local cooling on neuromuscular transmission in the myasthenic syndrome of Eaton and Lambert. J. Neurol. 217, 95 (1978)

    Article  Google Scholar 

  20. RILEY, D. A.: Tenotomy delays the postnatal development of the motor innervation of the rat soleus. Brain Res. 143, 162 (1978)

    Article  PubMed  CAS  Google Scholar 

  21. SAKAKIBARA, H., ENGEL, A. G., LAMBERT, E. H.: Duchenne dystrophy: ultrastructural localization of the acetylcholine receptor and intracellular microelectrode studies of neuromuscular transmission. Neurology (Minneap.) 27, 741 (1977)

    CAS  Google Scholar 

  22. SCHMIDT, R. F., THEWS, G.: Physiologie des Menschen: Berlin, Heidelberg, New York: Springer 1977

    Google Scholar 

  23. STATHAM, H. E., DUNCAN, C. J.: Dantrolene and the neuromuscular junction: evidence for intracellular calcium stores. Europ. J. Pharmacol. 39, 141 (1977)

    Google Scholar 

  24. VAN DER KLOOT, W.: Calcium and neuromuscular transmission. In: Calcium in drug action (éd. G. B. Weiss), p. 261. New York: Plenum Press 1979

    Google Scholar 

  25. VYSKO’CIL, F., SYROV’Y, I.: Do peripheral nerves contain a factor inducing acetylcholine sensitivity in skeletal muscle? Experientia 35, 218 (1979)

    Article  Google Scholar 

  26. WAERHAUG, O., KORNELIUSSEN, H., SOMMERSCHILD, H.: Morphology of motor nerve terminals on rat soleus muscle fibres reinner-vated by the original and by a “foreign nerve”. Anat. and Embryol. (Berl.) 151,1 (1978)

    Article  Google Scholar 

  27. ZAIMIS, E.: Neuromuscular junction. Berlin, Heidelberg, New York: Springer 1976

    Google Scholar 

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Struppler, A., Taleghani, B.M. (1980). Bau und Funktion der neuromuskulären Synapse. In: Ahnefeld, F.W., et al. Muskelrelaxanzien. Klinische Anästhesiologie und Intensivtherapie, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67817-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-67817-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10365-3

  • Online ISBN: 978-3-642-67817-2

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