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Lysophosphatidylcholine (Lysolecithin) and its Synthetic Analogues. Immunomodulating and Other Biologic Effects

  • P. G. Munder
  • M. Modolell
  • R. Andreesen
  • H. U. Weltzien
  • O. Westphal

Abstract

Since the early work of Bergenhem and Fahraeus on the hemolytic activity of naturally occurring 2-lysophosphatidylcholine (lysolecithin) (LPC) [12] this substance has off and on been considered as a biologically active compound. It is present as a minor phospholipid in the plasma (8–12%) [23] and cellular membranes (≥ 3%) [21, 27, for review 79]. It is highly surface-active (44.3 dyn/cm) [4] and, therefore, potentially cytotoxic if incubated with cells in serum — or plasma free —media [4, 30, 31, 33, 44, 72, 76]. Addition in sublytic amounts, however, stimulates phagocytosis [16, 20, 80], changes the surface properties of erythrocytes [36], increases the Concanavalin-A (Con-A)-induced agglutination of erythrocytes [75], and may be used as a cell-fusing agent [58]. Furthermore, it has been claimed to be involved in hypersensitivity [38, 70] and inflammatory reactions [17].

Keywords

Synthetic Analogue Peritoneal Cell Ehrlich Ascites Tumor Cell Primary Immune Response Antigenic Stimulus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • P. G. Munder
    • 1
  • M. Modolell
    • 1
  • R. Andreesen
    • 1
  • H. U. Weltzien
    • 1
  • O. Westphal
    • 1
  1. 1.Max-Planck-Institut für ImmunbiologieFreiburgFederal Republic of Germany

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