In Vitro Sensitization of Rat Mast Cells by Human Serum IgE Tested by Histamine Release
A successful sensitization of rat mast cells (RMC) by human IgE (HuIgE) was first reported by Perelmutter and Khera . In later experiments, Perelmutter and his collaborators confirmed these results [2–4] and other investigators also published positive results [5–7]. Nevertheless, Plaut et al.  were not able to sensitize RMC with HuIgE. The problem has still not been unambiguously solved.
KeywordsAspirin Histamine Myeloma FITC Mast
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- 3.Phills JA, Perelmutter L (1974) IgE mediated and non-IgE mediated allergic-type reactions to aspirin. Acta Allergol (Copenh) 29:474–490Google Scholar
- 4.Pontefract R, Perelmutter L (1976) An electron microscope study of receptor sites on rat mast cells for human Immunoglobulin E. Acta Allergol (Copenh) 31:184–192Google Scholar
- 5.Haddad ZH, Lopapa A, Korotzer J (1971) Direct demonstration of human Immunoglobulin E (IgE) on rat mast cells after passive sensitization in vitro. J Allergy 47:88Google Scholar