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Atopic Dermatitis: a Disease of Immuno-vegetative (Autonomic) Dysregulation

  • Conference paper
New Trends in Allergy

Abstract

Although atopic dermatitis is one of the most common diseases in general dermatology [4, 6, 14, 15, 30, 42, 64], its etiology still remains largely obscure despite a number of attractive hypotheses and pathophysiologic concepts. What we know for sure is listed as follows:

  • Dry skin

  • Hyper-IgE

  • Decreased cellular immunity

  • Abnormal pharmacological reactivity

  • Psychosomatic influence

This work was supported in part by Deutsche Forschungsgemeinschaft Nr. Ri 307

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References

  1. Aly R, Maibach HI, Sheinfield HR (1977) Microbial flora of atopic dermatitis. Arch Dermatol 113:780

    Article  PubMed  CAS  Google Scholar 

  2. Atherton DJ, Sewell M, Soothill JF, Wells RS, Chilvers CED (1978) A double blind controlled crossover trial of an antigen-avoidance diet in atopic eczema. Lancet 1:401

    Article  PubMed  CAS  Google Scholar 

  3. Avella J, Machen JE, Binder HJ, Askenase PW (1978) Effect of histamine H2-receptor antagonists on delayed hypersensitivity. Lancet 1:624

    Article  PubMed  CAS  Google Scholar 

  4. Borelli S, Schnyder UW (1962) Neurodermitis constitutionalis sive atopica, II. Teil: Ätiologie, Pathophysiologie,Pathogenese, Therapie. In: Miescher G, Storck H (eds) Entzündliche Dermatosen I. Springer, Berlin Göttingen Heidelberg (Handbuch der Haut und Geschlechtskrankheiten, suppl,vol II/1, pp 254–319)

    Google Scholar 

  5. Bourne HR, Lichtenstein LM, Melmon KL, Henney CS, Weinstein Y, Shearer GM (1974) Modulation of inflammation and immunity by cyclic AMP. Receptors for vasoactive hormones and mediators of inflammation regulate many leukocyte functions. Science 184:19

    Article  PubMed  CAS  Google Scholar 

  6. Braun-Falco O, Burg G (1974) Zelluläres Infiltrat und Kapillaren bei Neurodermitis diffusa. Quantitativ enzymzytochemische und histochemische Untersuchungen. Arch Dermatol Forsch 249:113

    Article  PubMed  CAS  Google Scholar 

  7. Buckley RH, Wray BB, Belmaker EZ (1972) Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. Pediatrics 49:70

    Google Scholar 

  8. Busse WW, Lee TP (1976) Decreased adrenergic responses in lymphocytes and granulocytes in atopic eczema. J Allergy Clin Immunol 58:586

    Article  PubMed  CAS  Google Scholar 

  9. Conroy MC, Adkinson NF, Lichtenstein LM (1977) Measurement of IgE on human basophils: relation to serum IgE and anti-IgE-induced histamine release. J Immunol 118:1317

    PubMed  CAS  Google Scholar 

  10. Cormane RH, Hamerlinck F, Husz S (1975) B and T lymphocytes in certain varieties of dermatitis. Ann NY Acad Sci 254:592

    Article  PubMed  CAS  Google Scholar 

  11. Cock W de, Cree J de, Verhaegen H (1978) Histamine receptor-bearing T lymphocytes in patients with allergy, autoimmune disease, or recurrent infection. Clin Immunol Immunopathol 11:1

    Article  PubMed  Google Scholar 

  12. Fantozzi R, Masini E, Blandina P, Mannaioni PF, Bani-Sacchi T (1978) Release of histamine from rat mast cells by acetylcholine. Nature 273:473

    Article  PubMed  CAS  Google Scholar 

  13. Frazer CM, Harrison LC, Venter J, Craig J (1980) Autoantibodies to β-adrenergic receptors in one allergic rhinitis and two asthma patients. J Allergy Clin Immunol 65, 223

    Google Scholar 

  14. Goerttler E, Schnyder UW (1975) Zur Erbprognose der Neurodermitis atopica (Prurigo Besnier, atopic dermatitis, endogenes Ekzem). Hautarzt 26:18

    PubMed  CAS  Google Scholar 

  15. Hanifin JM, Lobitz WC (1977) Newer concepts of atopic dermatitis. Arch Dermatol 113:663

    Article  PubMed  CAS  Google Scholar 

  16. Hanifin JM, Rogge JL (1977) Staphylococcal infections in patients with atopic dermatitis. Arch Dermatol 113:1383

    Article  PubMed  CAS  Google Scholar 

  17. Henderson WR, Smith L, Kaliner M (1978) Alpha adrenergic responses in asthma. Clin Res 26:447 A

    Google Scholar 

  18. Henney CS, Bourne HR, Lichtenstein M (1972) The role of cyclic 3′-5′-adenosine monophosphate in the specific cytotoxic activity of lymphocytes. J Immunol 108:1526

    PubMed  CAS  Google Scholar 

  19. Ishizaka K (1976) Cellular events in the IgE antibody response. Adv Immunol 23:1

    Article  PubMed  CAS  Google Scholar 

  20. Ishizaka K, Ishizaka T (1967) Identification of γE antibodies as a carrier of reaginic activity. J Immunol 99:1187

    PubMed  CAS  Google Scholar 

  21. Ishizaka K (1980) Regulation of the IgE response. Fougerau M, Dausset J (eds) Immunology 80, p 815

    Google Scholar 

  22. Ishizaki T (to be published) Fragility of skin mast cells tested by a series of compoind 48/80 solutions among the patients of atopic diseases. Monogr Allergy

    Google Scholar 

  23. Jacobs D, Houri M, Landon J, Merret IG (1972) Circulating levels of Immunoglobulin E in patients with cancer. Lancet 2:1059

    Article  PubMed  CAS  Google Scholar 

  24. Johnson HH, Deoreo GA, Lascheid WP, Mitchell F (1960) Skin histamine levels in chronic atopic dermatitis. J Invest Dermatol 34:237

    PubMed  CAS  Google Scholar 

  25. Juhlin L, Johansson SGO, Bennich H, Högmann C, Thyresson N: Immunglobulin E in dermatoses: levels in atopic dermatitis and urticaria. Arch Dermatol 100:12

    Google Scholar 

  26. Juto P, Strannegard Ö (1979) T lymphocytes and blood eosinophils in early infancy in relation to heredity for allergy and type of feeding. J Allergy Clin Immunol 64:38

    Article  PubMed  CAS  Google Scholar 

  27. Kaliner M (1977) Human lung tissue and anaphylaxis. Evidence that cyclic nucleotides modulate the immunologic release of mediators through effects on microtubular assembly. J Clin Invest 60:951

    Article  PubMed  CAS  Google Scholar 

  28. Kaposi M (1887) Pathologie und Therapie der Hautkrankheiten. Urban und Schwarzenberg, Berlin Wien, p 483

    Google Scholar 

  29. Katz DH (1977) Lymphocyte differentiation, recognition and regulation. Academic Press, New York

    Google Scholar 

  30. Katz DH (1978) Control of IgE antibody production by suppressor substances. J Allergy Clin Immunol 62:44

    Article  PubMed  CAS  Google Scholar 

  31. Kjellman NI (1976) Immunoglobulin E and atopic allergy in childhood. Medical Dissertation No 36, University of Linköping

    Google Scholar 

  32. Leyden JJ, Marples RR, Kligman AM (1974) Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 90:525

    Article  PubMed  CAS  Google Scholar 

  33. Lichtenstein LM, Bourne HR, Henney CS, Grennough WB (1973) Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. Further evidence for the role of cyclic adenosine 3′-5′-monophosphate. J Clin Invest 52:691

    Article  PubMed  CAS  Google Scholar 

  34. Lobitz WC, Campbell CJ (1953) Physiologic studies in atopic dermatitis (disseminated neurodermatitis). I. The local cutaneous response to intradermally injectid acetylcholine and epinephrine. Arch Dermatol 67:575

    Google Scholar 

  35. Marsh DG, Hsu SH, Hussain R, Meyers DA, Freidhoff LR, Bias WB (1980) Genetics of human immune response to allergens. J Allergy Clin Immunol 65:322

    Article  PubMed  CAS  Google Scholar 

  36. McGeady SJ, Buckley RH (1975) Depression of cell-mediated immunity in atopic eczema. J. Allergy Clin Immunol 56:393

    Article  PubMed  CAS  Google Scholar 

  37. Orgel HA, Hamburger RN, Bazaral M, Gorrin H, Groshong, T, Lenoir M, Miller JR, Wallace W (1975) Development of IgE and allergy in infancy. J Allergy Clin Immunol 56:296

    Article  PubMed  CAS  Google Scholar 

  38. Parker CW, Kennedy S, Eisen AZ (1977) Leukocyte and lymphocyte cyclic AMP response in atopic eczema. J Invest Dermatol 68:302

    Article  PubMed  CAS  Google Scholar 

  39. Pauwels R, Verschraegen G, Straeten M van der (1980) IgE antibodies to bacteria in patients with bronchial asthma. J Allergy Clin Immunol 65:167

    Google Scholar 

  40. Plaut M, Lichtenstein LM, Henney CS (1975) Properties of a subpopulation of T cells bearing histamine receptors. J Clin Invest 55:856

    Article  PubMed  CAS  Google Scholar 

  41. Poblete-Freundt G, Rauch C, Schönfeld W, Schmutzler W (1978) Effects of cholinergic stimulation on isolated mast cells from rat, guinea pig and man. Naunyn Schmiedebergs Arch Pharmacol [Suppl R47] 302:186

    Google Scholar 

  42. Rachelefsky GS, Opelz G, Mickey MR, Kiuchi M, Terasaki PI, Siegel SC, Stiehm ER (1976) Defective T cell function in atopic dermatitis. J Allergy Clin Immunol 57:569

    Article  PubMed  CAS  Google Scholar 

  43. Rajka G (1975) Atopic dermatitis. Saunders, London

    Google Scholar 

  44. Ray Wang S, Zweiman B (1978) Histamine suppression of human lymphocyte response to mitogens. Cell Immunol 36:28

    Article  Google Scholar 

  45. Ring J (1978) Zyklisches Adenosin-3–5-Monophosphat (c-AMP) und Allergie. Hautarzt 29:625

    PubMed  CAS  Google Scholar 

  46. Ring J (1979) Atopic dermatitis: a disease of general vasoactive mediator dysregulation. Int Arch Allergy Appl Immunol 59:233

    Article  PubMed  CAS  Google Scholar 

  47. Ring J, O’Connor R (1979) In vitro histamine and serotonin release studies in atopic dermatitis. Int Arch Allergy Appl Immunol 58:322

    Article  PubMed  CAS  Google Scholar 

  48. Ring J, Senter T, Arroyave CM, Cornell R, Tan EM (1978) Role of complement and histamine in atopic dermatitis (Abstract) Clin Res 26:210 A

    Google Scholar 

  49. Ring J, Allen DH, Mathison DA, Spiegelberg HL (1980) In vitro releasability of histamine and serotonin: studies of atopic patients. J Clin Lab Immunol 3:85

    PubMed  CAS  Google Scholar 

  50. Ring J, Mathison DA, O’Connor R (1981) In vitro cyclic nucleotide responsivity of peripheral leucocytes and platelets in patients suffering from atopic dermatitis. Int Arch Allergy Appl Immunol 65:1

    Article  PubMed  CAS  Google Scholar 

  51. Rocklin RE (1976) Modulation of cellular immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes. J Clin Invest 57:1051

    Article  PubMed  CAS  Google Scholar 

  52. Rostenberg A, Sulzberger MB (1937) Some results of patch tests. Arch Dermatol 35:433

    CAS  Google Scholar 

  53. Sampson HA, Buckley RH (1980) Regulation of IgE synthesis in vitro: effects of mitogens and irradiation of T cells. J Allergy Clin Immunol 65:166

    Google Scholar 

  54. Saxon A, Stevens R (to be published) Synthesis of human IgE in vitro in normals and high IgE atopy. Monogr Allergy

    Google Scholar 

  55. Schmutzler W, Poblete-Freundt G, Rauch K, Schoenfeld W (1979) Response to immunological or cholinergic stimulation of isolated mast cells from man, guinea pig and rat. Monogr Allergy 14:288

    PubMed  CAS  Google Scholar 

  56. Schöpf E (1974) Störung zellvermittelter Immunreaktionen bei Neurodermitis atopica. Verminderte Spontanrosettenbildung von T-Lymphozyten. Dermatologica 149:210

    Article  PubMed  Google Scholar 

  57. Spiegelberg HL, O’Connor R, Simon RA, Mathison DA (1979) Lymphocytes with Fc receptors for IgE in patients with atopic disorders. J Allergy Clin Immunol 63:146

    Google Scholar 

  58. Stingl G, Gazze L, Czarnecki N, Wolff K (1980) Suppressor T cell defect in atopic dermatitis. J Invest Dermatol 74:447

    Article  Google Scholar 

  59. Stone SP, Gleich GJ, Muller SA (1976) Atopic dermatitis and IgE. Relationship between changes in IgE levels and severity of disease. Arch Dermatol 112:1254

    Article  PubMed  CAS  Google Scholar 

  60. Strannegard IL, Strannegard Ö (1977) Increased sensitivity of lymphocytes from atopic individuals to histamine-induced suppression. Scand J Immunol 6:1225

    Article  PubMed  CAS  Google Scholar 

  61. Szentivanyi A (1968) The beta adrenergic theory of the atopic abnormality in asthma. J Allergy 42:203

    Article  Google Scholar 

  62. Tada T, Okamura K, Taniguchi M (1972) Regulation of homocytotropic antibody formation in the rat. J Immunol 108:1535

    PubMed  CAS  Google Scholar 

  63. Walsh G, Douglas S, Dahl M, Blumenthal MN (1980) Anti-IgE specific for staphylococcus aureus. J Allergy Clin Immunol 65:167

    Google Scholar 

  64. Whitlock FA (1976) Psychophysiological aspects of skin disease. Saunders, London Philadelphia Toronto

    Google Scholar 

  65. Wüthrich B (1975) Zur Immunpathologie der Neurodermitis constitutionalis. Huber, Bern Stuttgart Vienna

    Google Scholar 

  66. Bode U, Ring J, Neubert U (to be published) Intrakutantestungen und bakteriologische Untersuchungen bei Patienten mit atopischem Ekzem. Allergologie

    Google Scholar 

  67. Ring J, Lutz J (to be published) Decreased lysosomal enzyme release in atopic dermatitis. Arch Derm Res

    Google Scholar 

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Author information

Authors and Affiliations

  1. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München, Germany

    J. Ring

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  1. J. Ring
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Editors and Affiliations

  1. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Frauenlobstr. 9, D-8000, München 2, Germany

    Johannes Ring  & Günter Burg  & 

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Ring, J. (1981). Atopic Dermatitis: a Disease of Immuno-vegetative (Autonomic) Dysregulation. In: Ring, J., Burg, G. (eds) New Trends in Allergy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67807-3_36

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  • DOI: https://doi.org/10.1007/978-3-642-67807-3_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10346-2

  • Online ISBN: 978-3-642-67807-3

  • eBook Packages: Springer Book Archive

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