Abstract
This chapter deals with all pharmacologic effects of benzodiazepine-like compounds on neuronal and nonneuronal cells and tissues reported in the literature. In other words, we shall discuss all somatic effects of benzodiazepines investigated in experimental pharmacology and exclude effects on psychological functions which, in the animal, are identical with behavioral effects, since observation of free and scheduled behavior is the only means to obtain indirect information on drug-induced changes in the psychological activity of the laboratory animal. Behavioral effects of benzodiazepines are the subject of a special chapter in this volume (Dews, 1981). We shall mention effects of benzodiazepines in man only on exceptional occasions.
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Addendum Section B
Brissette, Y., Gascon, A.L.: The cardiorespiratory toxicity of ouabain in benzodiazepine-treat-ed rats. Toxicol. Appl. Pharmacol. 55, 235–244 (1980)
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Addendum Section C
Jordan, C., Tech, B., Lehane, J.R., Jones, J.G.: Respiratory depression following diazepam: Reversal with high-dose naloxone. Anesthesiology 53, 293–298 (1970)
Addendum Section G
Leslie, S.W., Friedman, M.B., Coleman, R.R.: Effects of chlordiazepoxide on depolarization-induced calcium influx into synaptosomes. Biochem. Pharmacol. 29, 2439–2443 (1980)
Addendum Section H
Bruni, G., Dal Pra, P., Dotti, M.T., Segre, G.: Plasma ACTH and Cortisol levels in benzodiazepine treated rats. Pharmacol. Res. Commun. 12, 163–175 (1980)
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Vogel, R.A., Frye, G.D., Wilson, J.H., Kuhn, C.M., Koepke, K.M., Mailman, R.B., Mueller, R.A., Breese, G.R.: Attenuation of the effects of punishment by ethanol: comparison with chlordiazepoxide. Psychopharmacology 71, 123–129 (1980)
Wilkinson, M., Moger, W.H., Grovestine, A.D.: Chronic treatment with Valium (diazepam) fails to affect the reproductive system of the male rat. Life Sci. 27, 2285–2291 (1980)
Addendum Section I
Smith, D.W., Rehncrona, S.: Inhibitory effects of different barbiturates on lipid peroxidation in brain tissue in vitro: comparison with the effects of promethazine and chlorpromazine. Anaesthesiology 53, 186–194 (1980)
Addendum Section J
Cooper, S.J.: Effects of enantiomers of oxazepam sodium hemisuccinate on water intake and antagonism of Picrotoxin- or naloxone-induced suppression of drinking by chlordiazepoxide in the rat. Neuropharmacology 19, 861–865 (1980)
Cooper, S.J., Francis, R.L.: Interaction of chlordiazepoxide and anorectic agents on rate and duration parameters of feeding in the rat. Psychopharmacology 69, 261–265 (1980)
Vogel, R.A., Frye, G.D., Wilson, J.H., Kuhn, C.M., Koepke, K.M., Mailman, R.B., Mueller, R.A., Breese, G.R.: Attenuation of the effects of punishment by ethanol: comparison with chlordiazepoxide. Psychopharmacology 71, 123–129 (1980)
Addendum Section K
Antoniadis, A., Müller, W.E., Wollert, U.: Benzodiazepine receptor interactions may be involv ed in the neurotoxicity of various penicillin derivatives. Ann. Neurol. 8, 71–73 (1980)
Callaghan, D.A., Schwark, W.S.: Pharmacological modification of amygdaloid-kindled seizures. Neuropharmacology 19, 1131–1136 (1980)
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Snead, D.C., Bearden, L.J., Pegram, V.: Effect of acute and chronic anticonvulsant administration on endogenous y-hydroxybutyrate in rat brain. Neuropharmacology 19, 41–52 (1980)
Addendum Section L
Igarashi, M., Storey, V.O.: Locomotor body equilibrium after diazepam injection in the squirrel monkey. ORL 36, 33–36 (1973)
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Rackham, A.: Opiate-induced muscle rigidity in the rat: effects of centrally acting agents. Neuropharmacology 19, 855–859 (1980)
Rommelspacher, H., Nanz, C.: Pharmacodynamic effects of harmane, a β-carboline formed in vivo. Arch. Pharmacol. 313, R 34 (1980)
Vogel, R.A., Frye, G.D., Wilson, J.H., Kuhn, C.M., Koepke, K.M., Mailman, R.B., Mueller, R.A., Breese, G.R.: Attenuation of the effects of punishment by ethanol: comparisons with chlordiazepoxide. Psychopharmacology 71, 123–129 (1980)
Addendum Section M
Cuomo, V., Cortese, I.: Effects of bicuculline and chlordiazepoxide on locomotor activity and avoidance performance in rats. Experientia 36, 1208–1210 (1980)
Martin, J.R., Oettinger, R., Driscoll, P., Baettig, K.: Effects of chlordiazepoxide and imipramine on maze exploration by rats. Neurosci. Letters Suppl. 5, 262 (1980)
Sansone, M.: Influence of benzodiazepine tranquilizers on amphetamine-induced locomotor stimulation in mice. Psychopharmacology 71, 63–65 (1980)
Sansone, M.: Influence of benzodiazepine tranquilizers on scopolamine-induced locomotor stimulation in mice. Psychopharmacology 71, 243–245 (1980)
Sansone, M., Oliverio, A.: Effects of chlordiazepoxide-morphine combination on spontaneous locomotor activity in three inbred strains of mice. Arch. Int. Pharmacodyn. 247, 71–75 (1980)
Addendum Section N
Poshivalov, V.P.: The integritiy of the social hierarchy in mice following administration of psychotropic drugs. Br. J. Pharmacol. 70, 367–373 (1980)
Addendum Section O
Henrik, J., Fusek, J., Hrdina, V.: The effect of clonazepam on atropine spikes in the limbic system. Acta Nerv. Sup. (Praha) 22, 209–210 (1980)
Kuruvilla, A., Uretsky, N.J.: Effects of sodium valproate on motor functions influenced by GABA. Pharmacologist 22, 185 (1980)
Kusaka, M., Horikawa, A., Meshi, T., Maruyama, Y.: Interaction of triazolam with desimipramine. Effects of single and repeated treatment on certain pharmacologic responses and brain catecholamine levels. Psychopharmacology 70, 255–261 (1980)
Menon, M.K., Clark, W.G., Vivonia, C.: Interaction between phencyclidine (PCP) and GABAergic drugs: clinical implications. Pharmacol. Biochem. Behav. 12, 113–117 (1980)
Persson, B.: Cardiovascular effects of intracerebroventricular GABA, glycine and muscimol in rat. Arch. Pharmacol. 313, 225–236 (1980)
Rackham, A.: Opiate-induced muscle rigidity in the rat: effects of centrally acting agents. Neuropharmacology 19, 855–859 (1980)
Risch, C., Kripke, D., Janowsky, D.: Flurazepam effects on methylphenidate-induced stereotyped behaviour. Psychopharmacology 70, 79–82 (1980)
Sansone, M.; Influence of benzodiazepine tranquilizers on amphetamine-induced locomotor stimulation in mice. Psychopharmacology 71, 63–65 (1980)
Sansone, M.: Influence of benzodiazepine tranquilizers on scopolamine-induced locomotor stimulation in mice. Psychopharmacology 71, 243–245 (1980)
Sansone, M., Oliverio, A.: Effects of chlordiazepoxide-induced combinations on spontaneous locomotor activity in three inbred strains of mice. Arch. Int. Pharmacodyn. 247, 71–75 (1980)
Thiébot, M.-H., Kloczko, J., Chermat, R., Simon, P., Soubrié, P.: Oxolinic acid and diazepam: their reciprocal antagonism in rodents. Psychopharmacology 6, 91–95 (1980)
Addendum Section Q
Trembley, J.P., Grenon, G.: Benzodiazepines modify synaptic depression, frequency facilitation and PTP of an identified cholinergic synapse of aplysia. Life Sci. 27, 491–496 (1980)
Addendum Section U
Bouyer, J.-J., Rougeul, A.: Comparative anxiolytic and hypnotic effects of 3 benzodiazepines on baboons. Electroencephalogr. Clin. Neurophysiol. 49, 401–405 (1980)
Fairchild, M.D., Jenden, D.J., Mickey, M.R., Yale, C.: The quantitative measurement of changes in EEG frequency spectra produced in the cat by sedative-hypnotics and neuroleptics. Electroencephalogr. Clin. Neurophysiol. 49, 382–390 (1980)
Iwata, N., Mikuni, N.: EEG change in the conscious rat during immobility induced by psychological stress. Psychopharmacology 71, 117–122 (1980)
Addendum Section W
Barmack, N.H., Pettorossi, V.E.: The influence of a GABA agonist, diazepam, on the vestibuloocular reflexes of the rabbit. Brain Res. Bull. 4, 697 (1979)
Geller, H.M., Hoffer, B.J., Taylor, D.A.: Electrophysiological actions of benzodiazepines. Fed. Proc. 39, 3016–3023 (1980)
Grant, S.J., Huang, Y.H., Redmont, D.E.: Benzodiazepines attenuate single unit activity in the locus coeruleus. Life Sci. 27, 2231–2236 (1980)
Matsuoka, I., Chikamori, Y., Takaori, S., Morimoto, M.: Effects of chlorpromazine and diazepam on neuronal activities of the lateral vestibular nucleus in cats. Arch. Otorhinolaryngol. (N.Y.) 209, 89–95 (1975)
Phillis, J.W., Wu, P.H.: Interactions between the benzodiazepines, methylxanthines and adenosine. J. Can. Sci. Neurol. 7, 247–249 (1980)
Riley, M., Scholfield, C.N.: Diazepam produces a mild intensification of inhibition. J. Physiol. (Lond.) 305, 102P–103P (1980)
Ryu, J.H., McCabe, B.F.: Effects of diazepam and dimenhydrinate on the resting activity of the vestibular neuron. Aerospace Med. 45, 1177–1179 (1974)
Sekitani, T., McCabe, B.F., Ryu, J.H.: Drug effects on the medial vestibular nucleus. Arch. Otolaryng. 93, 581–589 (1971)
Addendum Section X
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Addendum Section AA
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Haefely, W., Pieri, L., Polc, P., Schaffner, R. (1981). General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives. In: Hoffmeister, F., Stille, G. (eds) Psychotropic Agents. Handbook of Experimental Pharmacology, vol 55 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67767-0_2
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