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Biochemical Effects of Gerontopsychopharmacological Agents

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Psychotropic Agents

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 55 / 2))

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Abstract

Discussion of the biochemical effectiveness of gerontopsychopharmacological agents in gerontopsychiatric (i.e. demented) patients should be based on criteria concerning cerebral blood flow, cerebral oxygen consumption and cerebral glucose uptake as biologically important brain parameters which might be predominantly altered in dementia. Physiologically, a close relationship exists between cerebral blood flow on the one hand and the cerebral metabolic rates of oxygen and glucose on the other (Alberti et al., 1975; Alexander et al., 1965, 1968; Cohen et al., 1964,1968; Folbergrova et al., 1972; Gottstein et al., 1977, 1976; Granholm et al., 1969; Granholm and Siesjö, 1969, 1971; Hamer et al., 1976, 1978; Hoyer et al., 1974; Kaasik et al., 1970; Kogure et al., 1970; Siesjö and Messeter, 1971; Siesjö et al., 1971; Siesjö and Zwetnow, 1970; Zwetnow, 1970). Therefore these parameters should not be considered separately in dementia. Cerebral blood flow variations should also be discussed in dementia although the disturbances of the metabolic brain parameters might be of greater importance in this disease (see below).

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  1. Institut für Pharmakologie, Bayer AG, Aprather Weg 18a, D-5600, Wuppertal 1, Germany

    F. Hoffmeister

  2. Institut für Arzneimittel des Bundesgesundheitsamtes, Stauffenbergstraße 13, D-1000, Berlin 30, Germany

    G. Stille

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Hoyer, S. (1981). Biochemical Effects of Gerontopsychopharmacological Agents. In: Hoffmeister, F., Stille, G. (eds) Psychotropic Agents. Handbook of Experimental Pharmacology, vol 55 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67767-0_13

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