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Effect of Anaesthesia and Surgery on the Renin-Angiotensin-Aldosterone System

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Endocrinology in Anaesthesia and Surgery

Summary

Plasma renin activity, plasma aldosterone, plasma Cortisol and serum electrolytes were determined before, during and after surgery (9 days) in 6 patients undergoing combined general (halothane) and peridural anaesthesia (lymphadenectomy group), 3 patients receiving normotensive general (halothane) anaesthesia (gastrectomy group) and 3 patients undergoing normotensive peridural anaesthesia (total endoprothesis group).

There were only minor influences upon plasma renin activity, plasma aldosterone and plasma Cortisol by normotensive peridural anaesthesia both intra- and postoperatively. Patients undergoing normotensive general anaesthesia showed a stimulation of all the parameters mentioned above probably due to adrenocortical response to surgical stress. In these patients transitory hyperreninism occurred in the postoperative period. Combined general and peridural anaesthesia caused an excess secretion in renin related to controlled hypotension during operation with consecutive elevation in adrenal aldosterone release. Renin and aldosterone levels declined postoperatively. However, hyperreninism persisted.

The results demonstrate that various factors may contribute to the elevation of renin and aldosterone secretion observed during and after anaesthesia and surgery. Nonetheless, it is apparent from our findings that distinct arterial hypotension induced a long-acting stimulation of renal renin release.

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Authors
  1. F. Witassek
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  2. G. Hack
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  3. M. Marx
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  4. H. Vetter
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Editors and Affiliations

  1. Institut für Anaesthesiologie der Universität Bonn, Sigmund-Freud-Straße 25, D-5300, Bonn-Venusberg, Germany

    Horst Stoeckel  & Guido Hack  & 

  2. Dept. of Anaesthesiology, University of Hirosaki, Japan

    Tsutomu Oyama

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© 1980 Springer-Verlag Berlin Heidelberg

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Witassek, F., Hack, G., Marx, M., Vetter, H. (1980). Effect of Anaesthesia and Surgery on the Renin-Angiotensin-Aldosterone System. In: Stoeckel, H., Oyama, T., Hack, G. (eds) Endocrinology in Anaesthesia and Surgery. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67745-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-67745-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10211-3

  • Online ISBN: 978-3-642-67745-8

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