Thymectomy in Myasthenia Gravis: Pre- and Postoperative Treatment

  • R. W. C. Janzen
  • E. Farthmann
  • M. Doehn
  • L. Lachenmayer
Part of the Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine book series (A+I, volume 132)


Thymectomy in mayasthenia gravis patients is based on clinical experiences first published by Blalock in 1939 [2]. In early years thymectomy was the only manipulation to influence the defect of the immune system. A positive effect of thymectomy on myasthenic symptoms is reported by several authors since that time [1, 3, 8, 9, 14]. Thus, thymectomy became a standard method in myasthenia treatment next to symptomatic choline-esterase-inhibitor medication. The indication for early thymectomy was extended by Genkins et al. in 1975 to cases with isolated ocular myasthenic symptoms [4].


Mediastinal Mass Postoperative Treatment Of27 Case Thymus Hyperplasia Myasthenic Crisis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Balzereit F, Bay V, Otto H, Sobirey C (1972) Die Thymektomie im Behandlungsplan der Myasthenic Z Neurol 201:136PubMedCrossRefGoogle Scholar
  2. 2.
    Blalock A, Mason MF, Morgan HJ, Riven SS (1939) Myasthenia gravis and tumors of the thymic region. Ann Surg 110:544PubMedCrossRefGoogle Scholar
  3. 3.
    Emeryk B, Strugalska MH (1976) Evaluation of results of thymectomy in myasthenia gravis. J. Neurol 211:155PubMedCrossRefGoogle Scholar
  4. 4.
    Genkins G, Papatestas AE, Horowitz SH, Kornfeld P (1975) Studies in myasthenia gravis:early thymectomy. Am J Med 581:517CrossRefGoogle Scholar
  5. 5.
    Goldman AJ, Herrmann C, Keesey JC, Mulder DG, Brown WJ (1975) Myasthenia gravis and invasive thymoma: a 20 year experience. Neurology (Minneap) 25:1021Google Scholar
  6. 6.
    Goldstein G, Schlesinger DH (1975) Thymopoetin and myasthenia gravis: neostigmin responsive neuromuscular block produced in mice by a synthetic peptide fragment of thymopoetin. Lancet 2:256PubMedCrossRefGoogle Scholar
  7. 7.
    Janzen RWC, Lachenmayer L (1977) Früh- und Spätsyndrome bei Thymom. In: Hertel G, Mertens HG, Ricker K, Schimrigk K (Hrsg) Myasthenia gravis und andere Störungen der neuromuskulären Synapse. Thieme, Stuttgart S 132Google Scholar
  8. 8.
    Kark AE, Kirschner PA (1971) Total thymectomy by the transcervical approach. Brit J Surg 58:321PubMedCrossRefGoogle Scholar
  9. 9.
    Keynes G (1946) The surgery of the thymus gland. Brit J Surg 33:201PubMedCrossRefGoogle Scholar
  10. 10.
    Kreel I, Osserman KE, Genkins G, Kark AE (1967) Role of thymectomy in the management of myasthenia gravis. Ann Surg 165:111PubMedCrossRefGoogle Scholar
  11. 11.
    Loach AB, Young AC, Spalding JMK, Smith AC (1975) Postoperative management after thymectomy. Br Med J 1:309PubMedCrossRefGoogle Scholar
  12. 12.
    McQuillen MP, Leone MG (1977) A treatment carol: thymectomy revisited. Neurology (Minn) 27:1103Google Scholar
  13. 13.
    Secher O (1967) Anaesthetic management of the myastenic patient. Acta Anaesthesiol Scand 11:245PubMedCrossRefGoogle Scholar
  14. 14.
    Wolfe WG, Sealy WC, Young WG (1972) Surgical management of myasthenia gravis. Ann Thorac Surg 14:645PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • R. W. C. Janzen
  • E. Farthmann
  • M. Doehn
  • L. Lachenmayer

There are no affiliations available

Personalised recommendations