Influence of Neurogenic Blockade on the Endocrine Metabolic Response to Surgery
In response to various forms of stress the body reacts with some well-defined endocrine-metabolic changes primarily leading to substrate mobilization. The purpose of this stress-response is still not completely elucidated, and one view has been that it is an ancient neurophysiology reflex response . Another release mechanism could be specific metabolic demands by the traumatized tissue . Early experimental studies showed that afferent neurogenic stimuli from the traumatized area to the brain were the main release mechanism for the pituitary-adrenal response to trauma . During recent years we have studied the role of neurogenic stimuli as a release mechanism for the endocrine-metabolic response to elective surgery in man and this paper summarizes our results.
KeywordsEpidural Analgesia Cortisol Response Nitrogen Balance General Anaesthesia Group Hyperglycemic Response
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