Cardiotoxicity of Drugs Detected on Chicken Embryos

  • M. Peterka
  • R. Jelínek
  • O. Benešová
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 4)

Abstract

Results of direct observation of the effects of 9 drugs with known cardiotoxic properties upon the embryonic chick heart after intraamniotic administration on days 4 and 3 respectively, revealed the possibility of rough detection of cardiotoxic properties of newly developed drugs using the rapid, simple and inexpensive technique on chicken embryos.

Key words

Drug effects Cardiotoxicity Chick embryo Amitriptyline Centrophenoxine Clemastine Digitoxin Dosulepin Imipramine Maprotiline Mephenhydramine hydrochloride Strophantin 

References

  1. Jelínek, R., Peterka, M.: One hundred substances tested with CHEST. Presented at the 6th Conference of European Teratology Society, September 4–7, 1978. Budapest, HungaryGoogle Scholar
  2. Jelinek, R.: Embryotoxicity assay on morphogenetic systems. In: Evaluation of embryotoxicity, mutagenicity and cardiogenicity risks in new drugs. Benešová, O., Rychter, Z., Jelínek, R. (eds.), pp. 195–206. Praha: Universita Karlova 1979Google Scholar
  3. Marhan, O., Jelínek, R., Rychter, Z., Řežábek, K.: Seventeen drugs compared in embryotoxicity tests using pregnant animals and a morphogenetic system. In: Evaluation of embryotoxicity, mutagenicity and cardiogenicity risks in new drugs. Benešová, O., Rychter, Z., Jelínek, R. (eds.), pp. 219–227, Praha: Universita Karlova 1979Google Scholar
  4. Pickering, J. W.: Experiments on the hearts of mammalian and chick embryos, with special references to action of electric currents. J. of Physiol. 20, 165–222 (1896)Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • M. Peterka
    • 1
  • R. Jelínek
    • 1
  • O. Benešová
    • 2
  1. 1.Institute of Experimental Medicine ČSAVPraha 2Czechoslovakia
  2. 2.Department of Physiology and PharmacologyMedical Faculty of Hygiene U.K.Praha 2Czechoslovakia

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