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The Fate of Propoxur in Rat

  • W. Foss
  • J. Krechniak
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 4)

Abstract

The dynamics of absorption, distribution, biotransformation, and excretion of propoxur in rat was studied. The animals were given single doses of propoxur: a) 5 mg/kg intravenously (i.V.), b) 5 mg/kg 14-C labelled compound (1.5 μCi) intravenously, c) 50 mg/kg orally. The concentrations of propoxur and its metabolite 2-isopropoxyphenol were determined in blood, liver, kidneys, brain and urine. Pharmacokinetic data concerning absorption, distribution and excretion were calculated.

Key words

Carbamate insecticides Propoxur Metabolism Excretion Distribution 

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References

  1. Krechniak, J., Foss, W.: Determination of propoxur and 2-isopropoxyphenol in blood, urine and tissue. Bull. Environ. Contam. Toxicol. 23, 531–535 (1979)PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • W. Foss
    • 1
  • J. Krechniak
    • 1
  1. 1.Department of Chemical ToxicologyMedical School GdanskAl.Marksa 107Poland

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