Kinetics of Benzene Metabolism in Rats in Inhalation Exposure

  • I. Gut
  • E. Frantík
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 4)

Abstract

Rats inhaling benzene concentrations 400, 800, 2,000, or 4,000 mg m-3 for 6 h excreted similar amounts of phenol in urine; hence benzene metabolism was already capacity-limited at 400 mg m-3. The rate of phenol elimination in the course of 12 h inhalation of benzene, 2,000 mg m-3, was increasing; the in vitro rate of hepatic microsomal benzene metabolism was increasing accordingly. Phenobarbital (PB) pretreatment significantly increased phenol excretion in rats exposed to benzene at 800 mg m-3 and higher concentrations. This effect disappeared during 12 h benzene inhalation, although the in vitro hepatic microsomal benzene metabolism in PB rats was significantly higher than in the controls.

Key words

Benzene Phenol Phenobarbital Enzyme induction 

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References

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  2. Gut, I.: Effect of phenobarbital pretreatment on in vitro enzyme kinetics and in vivo biotransformation of benzene in the rat. Arch. Toxicol. 35, 195–206 (1976)PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • I. Gut
    • 1
  • E. Frantík
    • 1
  1. 1.Institute of Hygiene and EpidemiologyPrague 10Czechoslovakia

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