Behaviour Teratology Tests

  • T. Vergieva
  • Ch. Zaikov
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 4)


Alterations in postnatal development resulting from intrauterine exposure are best recognized by performing a number of behavioural tests for which the means for quantification should be a basic requirement. The authors have used a modification of the Wahlsten 18 test scale for assessment of the physical development and unconditioned reflex development, together with additional tests providing quantitative data for embryotoxicity evaluation.

For the progeny CNS function estimation in an open field procedure as modified by Butcher has proved to be of value. A water T maze has been used for the assessment of learning ability and memory capacity.

The results obtained with prenatal exposure to lead acetate, alcohol, styrene and the fungicide endodan were presented and discussed.


Quantitative Data Behavioural Test Additional Test Brain Research Memory Capacity 
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  1. Butcher, R. B., Stut, R. M., Berry, N. K.: Behavioral abnormalities in rats with neonatal jaundice. Amer. J. Ment. Defic. 75, 755–759 (1971)PubMedGoogle Scholar
  2. Wahlsten, D.: A developmental time scale for postnatal changes in brain and behavior of BGD2F2 mice. Brain Research 72, 251–264 (1974)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • T. Vergieva
    • 1
  • Ch. Zaikov
    • 1
  1. 1.Institute of Hygiene and Occup. HealthMedical AcademySofiaBulgaria

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