Abstract
The flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) is known to be activated to a potent mutagen in the Salmonella test system and to induce kidney tumors in long-term feeding studies in mice and rats. Administration of Tris-BP to rats leads to extensive tubular necrosis at doses of 250 mg/kg i.p. and higher. The histological lesion is present in most animals 24 h after administration. There is a close correlation between the increase in kidney weights, the degree of kidney damage and the increase in plasma urea levels. A continuous increase in kidney weights with respect to time is seen, 7 days after a dose of 250 mg/kg i.p. the kidney/body weight ratio is 192% of controls. The kidney damage is not altered by previous phenobarbital-treatment, whereas cobaltous chloride, an inhibitor of cytochrome P-450, slightly reduces the kidney damage.
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References
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© 1980 Springer-Verlag
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Dybing, E., Søderlund, E. (1980). Nephrotoxicity of the Flame Retardant Tris(2,3-Dibromopropyl)Phosphate. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_46
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DOI: https://doi.org/10.1007/978-3-642-67729-8_46
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10191-8
Online ISBN: 978-3-642-67729-8
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