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Elevated Mitotic Number in the Adrenal Cortex as a Reflection of Early Events in Growth Induction by Carcinogens and Promoters — A Possible Short-Term Assay

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Further Studies in the Assessment of Toxic Actions

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

Abstract

Growth stimulating influences such as partial hepatectomy, chemical promoters and various carcinogens act mitogenically on the adrenal cortex of rats. The proliferative response of this ‘non-target’ tissue is probably due to systemically operating mechanisms which are independent of the organotropism of a substance. Therefore, this in vivo test appears useful for short-term evaluation of the promoting action of chemical compounds.

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References

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Author information

Authors and Affiliations

  1. Institute of Pathology of the Friedrich-Schiller University Jena, 6900, Jena, GDR

    M. Danz & H. Urban

Authors
  1. M. Danz
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  2. H. Urban
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, DDR-6900, Jena, GDR

    Wolfgang Klinger

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© 1980 Springer-Verlag

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Danz, M., Urban, H. (1980). Elevated Mitotic Number in the Adrenal Cortex as a Reflection of Early Events in Growth Induction by Carcinogens and Promoters — A Possible Short-Term Assay. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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