Abstract
The effect of daily oral administration of LD50 1/40, 1/20 and 1/10 of an organophosphate pesticide DDVP (Dichlorvos) was studied in rabbits for its effect on the humoral immune response after vaccination with Salmonella typhi, as well as on cell-mediated immunity. Serum antibody titers of treated animals showed a dose-dependent fall compared with the controls. The skin redness measured in the tuberculin test showed the same dose-dependent tendency.
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References
Dési, I., Varga, L., Farkas, I.: Studies on the immunosuppressive effect of organochlorine and organophosphoric pesticides in subacute experiments. J. Hyg. Epid. Microbiol. Immunol. 22, 115–122 (1978)
Ercegovich, C. D.: Relationship of pesticides to immune responses. Fed. Proc. 32, 2010–2016 (1973)
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© 1980 Springer-Verlag
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Dési, I., Varga, L., Farkas, I. (1980). The Effect of DDVP, an Organophosphorus Pesticide on the Humoral and Cell-Mediated Immunity of Rabbits. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_38
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DOI: https://doi.org/10.1007/978-3-642-67729-8_38
Publisher Name: Springer, Berlin, Heidelberg
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