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Further Studies in the Assessment of Toxic Actions pp 148–150Cite as

Toxicity of Organotin Compounds in Chicken and Rats

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Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

Abstract

Di-methyltin-dichloride (DMTC), di-butyltin-dichloride (DBTC), di-octyltin-dichloride (DOTC) and two commercial products (CP 1, CP2) used as stabilizers in plastics induce a dose-related decrease of the thymus weight in young rats when given by gastric intubation for 10 or 14 days; in the chicken a decrease of the bursa Fabricii weight can also be observed. It is of interest, that there are distinct differences in response between the animal species. The sensitivity in acute toxicity tests does not correspond with the sensitivity of thymus and bursa Fabricii. The response is also dependent on the vehicle in which the agent is given.

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Reference

  • Seinen, W., Willems, M. J.: Toxicity of organotin compounds. I. Atrophy of thymus and thymus dependent lymphoid tissue in rats fed di-n-octyltindichloride. Toxicol. Appl. Pharmacol. 35, 63–75 (1976)

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Author information

Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, University of Münster, Germany

    M. Renhof, U. Kretzer, T. Schürmeyer, H. Skopnik & F. H. Kemper

Authors
  1. M. Renhof
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  2. U. Kretzer
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  3. T. Schürmeyer
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  4. H. Skopnik
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  5. F. H. Kemper
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, DDR-6900, Jena, GDR

    Wolfgang Klinger

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© 1980 Springer-Verlag

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Cite this paper

Renhof, M., Kretzer, U., Schürmeyer, T., Skopnik, H., Kemper, F.H. (1980). Toxicity of Organotin Compounds in Chicken and Rats. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_31

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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