Abstract
Many pharmacologically active substances (membrane active drugs, antimitotics, hormones, etc.) affect the immune system. According to the dosage of the drugs a continuous gradient from immunotoxic to immunosuppressive and immunostimulatory action can be recorded.
The effect of drugs on the immune system can be estimated by testing the:
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a)
natural factors of immunity (by inflammatory reactivity, phagocytosis, serum protein components, quantitative relation between macrophages, T and B lymphocytes in tissues and blood),
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b)
T cell-mediated immunity (TCMI) (as T lymphocyte transformation, cytotoxicity, augmentation and suppressor effects),
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c)
B cell-mediated immunity (BCMI) (immunoglobulin production, antibody formation, polyclonal activation).
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Šterzl, J. (1980). Immunopharmacology and its Toxicological Problems. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_26
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DOI: https://doi.org/10.1007/978-3-642-67729-8_26
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