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Further Studies in the Assessment of Toxic Actions pp 95–108Cite as

Immunotoxicity Assessment: Screening and Function Studies

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Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

Abstract

As a screening procedure to detect immunotoxic effects, different parameters are discussed. These criteria include growth, weight and histology of lymphoid and endocrine organs, haematology, as well as serum immunoglobulin concentrations which can be quantified using the enzyme-linked immunosorbent assay (ELISA).

Secondly, different function tests are discussed to assess in the rat the cell-mediated immunity, the humoral immunity and the phagocytosis by macrophages. These tests should be performed when in a screening study an indication of immunotoxicity is found at a relevant dose level. The aim of functional assessment is to determine the functional significance of an effect on the immune response and to gain more insight into the mode of action of the chemical.

Finally, examples are given of compounds that suppress or stimulate immune responses; and advantages are discussed of performing function tests during the developmental phase of the immune system.

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Author information

Authors and Affiliations

  1. National Institute of Public Health, P.O. Box 1, Bilthoven, The Netherlands

    J. G. Vos

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  1. J. G. Vos
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Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, DDR-6900, Jena, GDR

    Wolfgang Klinger

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© 1980 Springer-Verlag

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Vos, J.G. (1980). Immunotoxicity Assessment: Screening and Function Studies. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_25

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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