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Further Studies in the Assessment of Toxic Actions pp 89–91Cite as

Induction of Pituitary Tumours and Hyperprolactinemia in Female Rats by Estrogens. The Effect of Apomorphine, Reserpine and L-DOPA

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Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

Abstract

Prolonged estrogen treatment induced an enlargement of the anterior pituitary gland and finally resulted in irreversible pituitary tumours.

Using continuous estrogen delivery [subcutaneous (s.c.) cholesterol-estrogen implants], the effects of ethinyl estradiol and the likewise synthetic estrogens STS 153 and STS 456 have been studied with or without concomitant administration of a progestogen without anti-estrogenic activities (STS 557).

There was a dose-dependent prolactin cell-stimulating effect of all these estrogens. Ethinyl estradiol (EE2) had the most marked effect followed by STS 456 which coincides with the relative uterotrophic activity found in rats and mice. The elevated serum prolactin levels in rats with an EE2 implant for 6 months could be reduced slightly but not significantly by apomorphine and reserpine at a daily dose of 100 μg/animal and 5 μg/animal, respectively. Daily administration of 300 μg L-dopa led to a slight but insignificant increase of serum prolactin.

The high pituitary weight and serum prolactin levels induced by long-term EE2 treatment were partially reversible after implant withdrawal.

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References

  • Beck, W., Wuttke, W.: Desensitization of the dopaminergic inhibition of pituitary luteinizing hormone release by prolactin in ovariectomized rats. J. Endocr. 74, 67–74 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Breuer, H., Köster, G.: Interaction between estrogens and neurotransmitters: Biochemical mechanisms. Adv. Biosci. 15, 287–300 (1974)

    Google Scholar 

  • Goodman, G., Lawson, D.M., Gala, R. R.: The effects of neurotransmitter receptor antagonists on ether-induced prolactin release in ovariectomized, estrogen-treated rats. Proc. Soc. Exp. Biol. Med. 153, 225–229 (1976)

    PubMed  CAS  Google Scholar 

  • Horowski, R., Gräf, K.-J.: Influence of dopaminergic agonists and antagonists on serum prolactin concentrations in the rat. Neuroendocrinology 22, 273–284 (1976)

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Central Institute of Microbiology and Experimental Therapy, Academy of Sciences of GDR, Beutenbergstraße 11, 6900, Jena, GDR

    M. Koch, M. Oettel & H. Freund

  2. Division of Medicine, Friedrich Schiller University, 6900, Jena, Germany

    H. Lauterbach

Authors
  1. M. Koch
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  2. M. Oettel
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  3. H. Lauterbach
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  4. H. Freund
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, DDR-6900, Jena, GDR

    Wolfgang Klinger

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© 1980 Springer-Verlag

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Koch, M., Oettel, M., Lauterbach, H., Freund, H. (1980). Induction of Pituitary Tumours and Hyperprolactinemia in Female Rats by Estrogens. The Effect of Apomorphine, Reserpine and L-DOPA. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_24

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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