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Studies on the Detection of Chemical Carcinogens Using a Mammalian Cell Transformation Assay. A Correlated Study of BHK Cell Transformation and Bacterial Mutagenicity

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Further Studies in the Assessment of Toxic Actions

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

Abstract

Transformation of BHK 21/Cl 13 cells was used as a test system to detect the carcinogenic potential of Busulfan (Myleran). To correlate carcinogenicity of the compound with its mutagenic activity, bacterial mutagenicity was demonstrated in the Salmonella/microsome test.

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References

  • Adams, J. F.: Mutagenicity of some environmental chemicals in Salmonella test systems without microsomal activation. Mutat. Res. 53, 142–143 (1978)

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  • Ames, B. N., McCann, J., Yamasaki, E.: Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31, 347–364 (1975)

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  • Basler, A., Theiss, I., Röhrborn, G.: Cytogenetic effects of Busulfan in vivo on bone-marrow cells and oocytes of adult mice and liver cells of transplacentally exposed embryos. Environ. Mutagenesis 1, 233–238 (1979)

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  • Leonard, A., Leonard, E. D.: Cytogenetic effects of Myleran in vivo on bone-marrow cells from male mice. Mutat. Res. 56, 329–333 (1978)

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  • Styles, J. A.: A method for detecting carcinogenic organic chemicals using mammalian cells in culture. Br. J. Cancer 36, 558–563 (1977)

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Author information

Authors and Affiliations

  1. Department of Human Genetics and Anthropology, University of Düsseldorf, Universitätsstraße 1, 4000, Düsseldorf, Germany

    R. Strobel, W. Greb & G. Röhrborn

Authors
  1. R. Strobel
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  2. W. Greb
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  3. G. Röhrborn
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, DDR-6900, Jena, GDR

    Wolfgang Klinger

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© 1980 Springer-Verlag

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Strobel, R., Greb, W., Röhrborn, G. (1980). Studies on the Detection of Chemical Carcinogens Using a Mammalian Cell Transformation Assay. A Correlated Study of BHK Cell Transformation and Bacterial Mutagenicity. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_22

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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