Reduced Induction of Pyruvate Kinase After Feeding 2-Acetylaminofluorene

  • W. Fischer
  • E. Grund
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 4)

Abstract

After administration of carcinogens to laboratory animals reduced induction of some enzymes has been found which is believed to be associated with the carcinogenic process. It is suggested that this effect may be used for the testing of chemical substances for carcinogenicity. For this purpose the dietary induction of pyruvate kinase in rat liver was investigated after feeding 2-acetylaminofluorene. The induced activity in the animals fed the carcinogen was found to be significantly lower than in the control, however, the extent of this reduction was too low to be used for testing chemical substances for carcinogenicity.

Key words

Pyruvate kinase Enzyme induction Acetylaminofluorene 

References

  1. Fischer, W.: Die Beeinflussung der Enzyminduktion als Früheffekt karzinogener Substanzen. Arch. Geschwulstforsch. 41, 52–64 (1973)PubMedGoogle Scholar
  2. Poirier, L. A., Poirier, M. C., Pitot, H. C.: Dietary induction of some enzymes of carbohydrate metabolism during 2-acetylaminofluorene feeding. Cancer Res. 20, 470–474 (1969)Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • W. Fischer
    • 1
  • E. Grund
    • 1
  1. 1.Institute of PathologyMedical Academy ErfurtErfurtGermany

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