Abstract
The mutagenic activity of the carcinogens benz[a]pyrene and dimethylnitrosamine after being metabolised by postmitochondrial liver fractions (S-9) from rats, Syrian hamsters and rabbits was estimated in the Ames’ test. The liver donors were pretreated with phenobarbital, 3-meth-ylcholanthrene, PCB (Delor 106) or peanut oil. Parallel to the mutagenicity tests, enzymes of S-9 such as dimethylnitrosamine demethylase and aryl hydrocarbon hydroxylase were estimated and their activity evaluated with reference to the results of the Ames’ test.
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References
Ames, B. N., McCann, J., Yamasaki, E.: Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mut. Res. 31, 347–364 (1975)
Butschak, G., Teichmann, B., Scheunig, G., Ziebarth, D.: Die Wirkung von polychlorierten Biphenylen (Kanechlor 500 und Delor 106) und von 3-Methylcholanthren auf die Aktivität mikrosomaler Enzyme der Rattenleber. Acta biol. med. germ. 37, 969–977 (1978)
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© 1980 Springer-Verlag
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Teichmann, B., Butschak, G., Scheunig, G., Köhler, S. (1980). Metabolizing Activities of Postmitochondrial Liver Fractions (S-9) on Benzo[a]pyrene and Dimethylnitrosamine. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_19
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DOI: https://doi.org/10.1007/978-3-642-67729-8_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10191-8
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