The Influence of Haloperidol Pretreatment on the Morphine Toxicity

  • K. Andreas
  • H.-D. Fischer
  • E. Rudolph
  • G. Brösgen
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 4)

Abstract

The influence of dopaminergic modifiers on morphine-induced analgesia and lethality was studied comparing both the effect of a single pre-dose of haloperidol and and continuous pretreatment for three weeks with haloperidol. A single administration of haloperidol enhanced morphine-induced analgesia probably due to the receptor blocking action of haloperidol which supports the reduction of dopamine release produced by morphine. The daily haloperidol administration for 3 weeks however decreased the analgesic action of morphine in consequence of a dopamine receptor supersensitivity developed in this time. The lethality was increased under both conditions. These results suggest that the dopaminergic system, dependent upon its sensitivity, plays a modulating role in morphine-induced analgesia, but not in morphine-induced lethality.

Key words

Morphine Haloperidol Dopamine Mortality Analgesia Lethal dose 50 Neural transmission Supersensitivity 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • K. Andreas
    • 1
  • H.-D. Fischer
    • 1
  • E. Rudolph
    • 1
  • G. Brösgen
    • 1
  1. 1.Institute of Pharmacology and ToxicologyMedical Academy “Carl Gustav Carus”801 DresdenGermany

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