Zusammenfassung
Kapilläre Perfusion, alveolo-kapilläre Permeation und alveoläre Ventilation bilden unter physiologischen Bedingungen eine organ-charakteristische Funktionseinheit im Dienste der Lungenatmung, deren generalisierte Störung zur klinischen Symptomatik einer akuten respiratorischen Insuffizienz führt. Die akute respiratorische Insuffizienz der Lungen kann mithin als das klinische Äquivalent einer polyaetiologischen, generalisierten, akuten und zur Automation und Progression neigenden Störung dieser Funktionseinheit definiert werden. Initiale Perfusionsstörungen der Lungenstrombahn, bei denen die Lungenstrombahn in generalisierte Mikrozirkulations- und Verteilungsstörungen der Kreislaufperipherie vor der Lunge einbezogen wird, gelten als die häufigste Ursache der akuten respiratorischen Insuffizienz. Die akute respiratorische Insuffizienz kann im Prinzip jedoch auch durch primäre Permeationsstörungen im Bereich der alveolo-kapillären Austauschmembranen oder durch primäre Stoffwechselirritationen der Alveolarepithele initiiert werden.
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Literatur
Bachofen M, Weibel ER (1974) Basic pattern of tissue repair in human lungs following unspecific injury. Chest 65: 4 (Suppl)
Barnhart MI, Noonan SM (1973) Cellular control mechanisms for blood clotting proteins. In: Brinkhous KM, Surgenor DM, Hinnom S, Sherry S, Stengle JM (eds) Thrombosis: Mechanisms and Control. Schattauer, Stuttgart New York, p 59
Benzer H (1975) Oberflächenspannung in der Lunge und Schocklunge. Verh Dtsch Ges Inn Med 81: 455–462
Bignon J, Jaubert F, Jaurand MC (1977) Ultrastructural basis for pulmonary capillary permeability to autologous plasma proteins and to exogenous proteinic tracers. Chest 71: 294
Bleyl (1971) Pathomorphologie und Pathogenese des Atemnotsyndroms. Verh Dtsch Ges Path 55: 55: 39
Bleyl U (1977) Morphological diagnosis of disseminated intravascular coagulation: histologic, histochemical and electronmicroscopic studies. Seminars in Thrombosis and Hemostasis 3: 247
Bleyl U (1978) Hämostase und Schocklunge. Verh Dtsch Ges Path 62: 39
Bleyl U Die Atemnotsyndrom-Lunge — Sequestrationsorgan für lösliches Fibrin. Schweizerisches Symposium über akutes Lungenversagen 1978 (im Druck)
Bleyl U, Büsing CM (1973) Pathogenese pulmonaler hyaliner Membranen. In: Wiemers K, Scholler KL (Hrsg) Lungenveränderungen bei Langzeitbeatmung. Internat Symposium Freiburg 1971, Thieme Stuttgart
Bleyl U, Rossner JA (1976) Globular hyaline microthrombi — their nature and morphogenesis. Virchows Arch A Path Anat Histol 370: 113
Brass EP, Forman WB, Edwards RV, Lindan O (1976) Fibrin formation: The role of the fibrinogen fibrin complex. Thrombos Haemostas 36: 37
Brown ES (1964) Isolation and assay of dipalmitoyllecithin in lung extracts. Am J Physiol 207: 402
Büsing CM, Bleyl U (1977) Plasminogen activator activity of pulmonary vessels in shock. Thrombos Res 11: 285
Coalson JJ, Hinshaw LB, Guenter CA (1970) The pulmonary ultrastructure in septic shock. Exp molec Path 12: 84
Fletcher AP, Alkjaersig N, O’Brien J (1970) Blood hypercoagulability and thrombosis. XIII. Inter¬nat. Congr. of Haematology, Munich, 2–8., p 244
Fung YC, Sobin SS (1969) Theory of sheet flow in lung alveoli. J appl Physiol 26: 472
Fung YC, Sobin SS (1972) Pulmonary alveolar blood flow. Circulat Res 30: 470
Goodwin MN Jr (1971) Deficiency of pulmonary surfactant in metabolic acidosis. Amer J Path 62: 49
Graeff H, Hugo R, Hafter R (1973) In vivo formation of soluble fibrin monomer complexes in human plasma. Thrombos Res 3: 465
Graeff H, Hugo R, Hafter R (1978) Evaluation of hypercoagulability and intravascular coagulation by estimation and characterization of soluble fibrin monomer complexes (SFMCs). In: Davidson JF, Rowan RM, Samama NM, Desnoyers PC (eds) Progress in Chemical Fibrinolysis and Thrombolysis. Raven Press, New York, p 435
Hafter R, Müller-Berghaus G, Hugo R, Graeff H (1977) Estimation and characterization of soluble fibrin monomer complexes during endotoxin induced intravascular coagulation. Thrombos Res 10: 711
Hallmann MK, Miyal K, Wagner RM (1975) Isolated lamellar bodies from rat lung. Correlated ultra- structural and biochemical studies. Lab Invest 32: 295
Hughes JMB (1977) Pulmonary edema. In: West JB (ed) Regional differences in the lung. Academic Press, New York London
Hugo R, Hafter R, Stemberger A, Graeff H (1977) Complex formation of crosslinked fibrin oligomers with agarose coupled fibrinogen and fibrin. Hoppe-Seylers Z Physiol Chem 358: 1359
Inoue S, Michel RP, Hogg JC (1976) Zonulae occludentes in alveolar epithelium and capillary endothelium of dog lungs studied with the freeze-fracture technique. J Ultrastruct Res 56: 215
Klaus MH, Clements JA, Havel RJ (1961) Composition of surface-active material isolated from beef lung. Proc Nat Acad Sci USA 47: 1858
Lauweryns JM (1971) Stereomicroscopic funnel-like architecture of pulmonary lymphatic vessels. Lymphology 4: 125
Lauweryns JM, Baert JH (1977) Alveolar clearance and the role of the pulmonary lymphatics: Amer Rev Resp Dis 115: 625
Manasse P (1892) Über hyaline Ballen und Thromben in den Gefäßen bei akuten Infektionskrankheiten. Virchows Arch 130: 217
Meyer BJ, Meyer A, Guyton AC (1968) Interstitial fluid pressure. Circulat Res 22: 263
Movat HZ, Uriuhara T, Macmorine DL, Burke JS (1964) A permeability factor released from leukocytes after phagocytosis of immun complexes and its possible role in the arthus reaction. Life Sci 3: 1025
Movat HZ, Udaka K, Takeuchi Y (1970) Plymorphonuclear leukocyte lysosomes and vascular injury. In: Koller F, Brinkhous KM, Biggs R, Rodman NF, Hinnom S (eds) Vascular Factors and Thrombosis. Schattauer, Stuttgart New York, p 211
Murray JF (1976) The Normal Lung. Saunders, Philadelphia London Toronto
Pingleton WW, Coalson JJ, Hinshaw LB, Guenter CA (1972) Effect of steroid pretreatment on development of shock lung. Lab Invest 27: 445
Ratliff NB, Wilson JW, Mikat E, Hackel DB (1970) Altered leukocytes in pulmonary vessels of dogs in hemorrhagic shock. Microsvasc Res 2: 241
Ratliff NB, Wilson JW, Mikat E, Hackel DB, Graham TC (1971) The lung in hemorrhagic shock. Amer J Path 65: 325
Rüfer R (1971) Surfactant inhibition in vitro. X XV. International Congress of Physiological Sciences. Proceedings of the Internat. Union of Physiological Sciences IX (Abstract)
Sandritter W, Mittermayer C, Riede UN, Freudenberg N, Grimm H (1978) Shock lung syndrome (a general review). Path Res Pract 162: 7
Sasaki T, Page JH, Shainoff JR (1966) Stable complex of fibrinogen and fibrin. Science 152: 1069
Schlag G, Voigt WH, Schnells G, Glatzl A (1976) Die Ultrastruktur der menschlichen Lunge im Schock. I. Anaesthesist 25: 512–521
Schmid-Schönbein H (1977) Microrheology of erythrocytes and thrombocytes, blood viscosity and the distribution of blood flow in the microcirculation. In: Meessen H (ed) Mikrozirkulation Springer, Berlin Heidelberg New York Handbuch der allgemeinen Pathologie III/7, p 289
Schneeberger EE (1977) Ultrastructure of intercellular junctions in the freeze fractured alveolar- capillary membrane of mouse lung. Chest 71: 299
Sherman LA (1972) Fibrinogen turnover: Demonstration of multiple pathways of catabolism. J Labor Clin Med 79: 710
Sherman LA (1977) Catabolism of fibrinogen and its derivatives. Thrombos Haemostasis (Stuttg) 38: 809
Sherman LA, Harwig S, Lee J(1975)In vitro formation and in vivo clearance of fibrinogen complexes. J Labor Clin Med 86:100
Strieder DJ (1976) Physical factors in lung functions. In: Kazemi H (ed) Disorders of the respiratory system. Grune & Stratton, New York San Francisco London, p 12
Taylor FB Jr, Abrams ME (1964) Inhibition of clot lysis by a surface active lipoprotein from lung and inhibition of its surface activity by fibrinogen. Physiologist 7: 269
Taylor FB Jr, Abrams ME (1966) Effect of surface active lipoprotein on clotting and fibrinolysis, and of fibrinogen on surface tension of surface active lipoprotein. With a hypothesis on the pathogenesis of pulmonary atelectasis and hyaline membrane in respiratory distress syndrome of the newborn. Amer J Med 40: 346
Urbaschek B (1971) The effects of endotoxins in the microcirculation. In: Kadis S, Weinbaum G, Ajl SJ Microbial Toxins, vol. V, Academic Press, New York London, p 261
Wiehert P (1978) Alveolarwandphysiologie und Surfactant. Verh Dtsch Ges Path 62: 29
Zenker K (1895) Über intravasale Fibringerinnung bei der Thrombose. Beitr path Anat 17: 448
Zweifach BW (1961) Functional behavior of the microcirculation. Thomas, Springfield
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Bleyl, U. (1980). Die pathologische Anatomie der akuten respiratorischen Insuffizienz. In: Peter, K. (eds) Akute respiratorische Insuffizienz. Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine, vol 131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67723-6_4
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