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Hypertension: Mechanisms and Management pp 169–182Cite as

Enhanced Parotid Kallikrein Secretion in Essential, Adrenal Hypertension and in Advanced Renal Failure — Inverse Relationship to Sodium Excretion

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Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

Abstract

There are several lines of evidence that the renal kallikrein-kinin system (KKS) is altered in various forms of hypertension, probably indicating a defective vasodepressor system as a pathogenetic factor in blood pressure regulation. Urinary kallikrein excretion was found to be decreased in patients with essential [9, 15, 18, 19, 35], renovascular [13] and renoparenchymal hypertension [25, 27] and elevated in primary aldosteronism [18, 27]. Furthermore, a dependence of the activity of the renal KKS on factors involved in the pathogenesis of hypertension (extracellular volume [21], sodium- and potassium balance [1, 10, 19, 22, 26, 36], and mineralocorticoids [19]), was established.

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Authors
  1. A. Röckel
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  2. G. Stürmer
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  3. G. Schmid
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  4. A. Heidland
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Editors and Affiliations

  1. I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität Mainz, Langenbeckstraße 1, D-6500, Mainz, Germany

    Thomas Philipp  & Armin Distler  & 

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© 1980 Springer-Verlag Berlin Heidelberg

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Röckel, A., Stürmer, G., Schmid, G., Heidland, A. (1980). Enhanced Parotid Kallikrein Secretion in Essential, Adrenal Hypertension and in Advanced Renal Failure — Inverse Relationship to Sodium Excretion. In: Philipp, T., Distler, A. (eds) Hypertension: Mechanisms and Management. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67712-0_17

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  • DOI: https://doi.org/10.1007/978-3-642-67712-0_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10171-0

  • Online ISBN: 978-3-642-67712-0

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