Glandular Adenylate Cyclase System in Genetic Hypertension — Age-Dependent Response to Catecholamines
Various approaches have been made to evaluate the role of central and peripheral catecholaminergic mechanisms as to their effect on the pathogenesis of high arterial blood pressure in spontaneously hypertensive rats (SHR). Both sympatho-neural and sympatho-adrenal malfunctions are involved in causing and possibly maintaining arterial hypertension in SHR and yet, the experimental evidence that has been published to date is often divergent and the underlying mechanisms are still not completely defined.
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