Introduction

Abstract

Wilhelm His, one of the founders of developmental neurobiology, was convinced “that the processes of generation and development obey fundamental and simple laws and submit to the general laws of nature”(His 1901). Therefore, we should be able to find immediate conditions, dependencies and rules determining the development of an organic form. With this in mind, His (1874) defined the task of embryology as follows: “Developmental biology is essentially a physiological science; it has not only to describe how each individual form develops from the egg, it has to derive this development in such a way that each developmental stage together with all its specialities appears as a necessary consequence of the immediately preceding stage ... Only if developmen tal biology has given a perfect physiological derivation for any given form, has it the right to say that it has explained this individual form.”The ultimate aim of a physiological derivation would be that laws of growth valid for organic beings can be expressed as mathematical formulae (His 1874). To exemplify this, he formulated a universal and purely formal law of growth in mathematical terms making the comment: “I now suggest that the body form follows immediately from germinal growth and can be derived from the given germinal form according to the laws of growth. My interest is, therefore, firstly to detect the law of growth empirically and secondly to derive consecutive forms of the developing organism by applying this law.”